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Pancreatic beta-cell maintenance by parasympathetic nerve

Research Project

Project/Area Number 23591315
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionYokohama City University

Principal Investigator

ITO Yuzuru  横浜市立大学, 医学部, 助教 (00512980)

Co-Investigator(Kenkyū-buntansha) TERAUCHI Yasuo  横浜市立大学, 医学研究科, 教授 (40359609)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords膵β細胞 / アセチルコリン / GLP-1 / GLP-1 / 副交感神経 / インスリン
Research Abstract

We investigated the molecular mechanism of acetylcholine which was the major neurotransmitter of the parasympathetic nerve, in pancreatic beta-cell maintenance. Pancreatic beta-cell proliferation was caused by the acetylcholine administration in pancreatic beta-cell line (MIN6) and mouse. It is known that the molecules such as IRS-2, Akt and MAPkinase, make the important role in mechanism of pancreatic beta-cell proliferation. However, acetylcholine was able to stimulate the pancreatic beta-cell proliferation independently of these molecules. GLP-1 secretion was increased by the acetylcholine administration in mouse. It was suggested that acetylcholine caused beta-cell proliferation through GLP-1.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (35 results)

All 2014 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 18 results) Presentation (13 results)

  • [Journal Article] 最新肥満症候学V.症候性肥満の成因と病態インスリノーマ2014

    • Author(s)
      伊藤譲,寺内康夫
    • Journal Title

      日本臨床

      Volume: 72 Pages: 342-346

    • Related Report
      2013 Final Research Report
  • [Journal Article] 最新肥満症候学 V.症候性肥満の成因と病態 インスリノーマ2014

    • Author(s)
      伊藤譲、寺内康夫
    • Journal Title

      日本臨床

      Volume: 72 Pages: 342-346

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Glycemic control after addition of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes showing inadequate response to thrice-a-day treatment with α-glucosidase inhibitors.2013

    • Author(s)
      Masuda K, Aoki K, Kamiko K, Takihata M, Ito Y, Nagakura M, Kawasaki S, Akema N, Hasegawa M, Nakajima S, Shinoda K, Toumura S, Tsunoda S, Enomoto H, Shimotomai H, Terauchi Y.
    • Journal Title

      Expert Opin Pharmacother.

      Volume: 14 Issue: 9 Pages: 1111-1118

    • DOI

      10.1517/14656566.2013.790365

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration.2013

    • Author(s)
      Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi Y.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 5 Pages: e64633-e64633

    • DOI

      10.1371/journal.pone.0064633

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 Mice.2013

    • Author(s)
      Tajima K, Nakamura A, Shirakawa J, ogashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi, Y
    • Journal Title

      Am. J. Physiol Endocrinol. Metab

      Volume: 305

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trefoil Factor 2 Promotes Cell Proliferation in Pancreaticβ-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation2013

    • Author(s)
      Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi, Y
    • Journal Title

      Endocrinology

      Volume: 154(1) Issue: 1 Pages: 54-64

    • DOI

      10.1210/en.2012-1814

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice.2013

    • Author(s)
      Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 305

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycemic control after addition of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes showing inadequate response to thrice-a-day treatment with α-glucosidase inhibitors.2013

    • Author(s)
      Masuda K, Aoki K, Kamiko K, Takihata M, Ito Y, Nagakura M, Kawasaki S, Akema N, Hasegawa M, Nakajima S, Shinoda K, Toumura S, Tsunoda S, Enomoto H, Shimotomai H, Terauchi Y.
    • Journal Title

      Expert Opin Pharmacother

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] KEYWORD SREBP脂肪肝や糖インスリン代謝など生活習慣病に深くかかわる2012

    • Author(s)
      伊藤譲,寺内康夫
    • Journal Title

      Cardio-Lipidology

      Volume: 6 Pages: 80-83

    • NAID

      40019408648

    • Related Report
      2013 Final Research Report
  • [Journal Article] Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, beta cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet2012

    • Author(s)
      Sato K, Nakamura A, Shirakawa J, Muraoka T, Togashi Y, Shinoda K, Orime K, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Endocrinology

      Volume: 153(3) Issue: 3 Pages: 1093-102

    • DOI

      10.1210/en.2011-1712

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions2012

    • Author(s)
      Nakamura A, Togashi Y, Orime K, Sato K, Shirakawa J, Ohsugi M, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Diabetologia

      Volume: (In press) Issue: 6 Pages: 1745-1754

    • DOI

      10.1007/s00125-012-2521-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes2012

    • Author(s)
      Shirakawa J, Togashi Y, Tajima K, Orime K, Kikuchi K, Miyazaki T, Sato K, Kimura M, Goshima Y, Terauchi Y
    • Journal Title

      Diabetes Res Clin Pract

      Volume: (In press) Issue: 1 Pages: e9-e12

    • DOI

      10.1016/j.diabres.2012.03.017

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of liraglutide on β cell-specific glucokinase-deficient neonatal mice2012

    • Author(s)
      Shirakawa J, Tanami R, Togashi Y, Tajima K, Orime K, Kubota N, Kadowaki T, Goshima Y, Terauchi Y
    • Journal Title

      Endocrinology

      Volume: (In press) Issue: 7 Pages: 3066-75

    • DOI

      10.1210/en.2012-1165

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protection from nonalcoholic steatohepatitis and liver tumorigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance.2012

    • Author(s)
      Nakamura A, Tajima K, Zolzaya K, Sato K, Inoue R, Yoneda M, Fujita K, Nozaki Y, Kubota KC, Haga H, Kubota N, Nagashima Y, Nakajima A, Maeda S, Kadowaki T, Terauchi Y
    • Journal Title

      Diabetologia

      Volume: 55(12) Issue: 12 Pages: 3382-3391

    • DOI

      10.1007/s00125-012-2703-1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trefoil factor 2 promotes cell proliferation in pancreatic β cells through CXCR-4-mediated ERK1/2 phosphorylation.2012

    • Author(s)
      Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y.
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 54-64

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] KEYWORD SREBP 脂肪肝や糖インスリン代謝など生活習慣病に深くかかわる2012

    • Author(s)
      伊藤譲、寺内康夫
    • Journal Title

      Cardio-Lipidology

      Volume: 6 Pages: 80-83

    • NAID

      40019408648

    • Related Report
      2012 Research-status Report
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, EzakiO, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab

      Volume: 13(3) Issue: 3 Pages: 294-307

    • DOI

      10.1016/j.cmet.2011.01.018

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice2011

    • Author(s)
      Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y
    • Journal Title

      Diabetes

      Volume: 60(4) Issue: 4 Pages: 246-1257

    • DOI

      10.2337/db10-1338

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of a DPP-4 inhibitor against increased beta cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes2011

    • Author(s)
      Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y
    • Journal Title

      J Biol Chem

      Volume: 286(29) Issue: 29 Pages: 25467-76

    • DOI

      10.1074/jbc.m110.217216

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet2011

    • Author(s)
      Muraoka T, Aoki K, Iwasaki T, Shinoda K, Nakamura A, Aburatani H, Mori S, Tokuyama K, Kubota N, Kadowaki T, Terauchi Y
    • Journal Title

      Metabolism

      Volume: 60 Issue: 5 Pages: 617-28

    • DOI

      10.1016/j.metabol.2010.06.008

    • NAID

      40018948824

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice2011

    • Author(s)
      Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E and Terauchi Y
    • Journal Title

      Diabetes

      Volume: 60 Pages: 1246-1257

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protective effect of a dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes.2011

    • Author(s)
      Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 25467-25476

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Subclinical Cushing症候群を呈し、家族内発症が疑われたACTH非依存性大結節性副腎皮質過形成(AIMAH)の1例2014

    • Author(s)
      井 正法, 田島 一樹, 吉井 大司, 奥山 朋子, 伊藤 譲, 寺内 康夫
    • Organizer
      第603回日本内科学会関東地方会
    • Place of Presentation
      日内会館4階(東京都文京区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高インスリン血性低血糖を伴う糖尿病に対しジアゾキサイドとエキセナチドの併用で血糖コントロールを行った1例2014

    • Author(s)
      田村 哲哉, 白川 純, 室橋 祐子, 山崎 俊介, 富樫 優, 伊藤 譲, 寺内 康夫
    • Organizer
      第603回日本内科学会関東地方会
    • Place of Presentation
      日内会館4階(東京都文京区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GLP-1受容体作動薬治療中止後も頻回の低血糖を起こした糖尿病患者の一例2014

    • Author(s)
      山口 博行、伊藤 譲、力武 麻美、室橋 祐子、奥山 朋子、山崎 俊介、吉井 大司、白川 純、富樫 優、寺内 康夫
    • Organizer
      第51回日本糖尿病学会関東甲信越地方会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠糖尿病にてインスリン治療が必要となった症例の臨床背景に関する検討2013

    • Author(s)
      伊藤譲,澁谷誠,吉村公一郎,細川紗帆,山本葉子,永田亮,杉浦賢,寺内康夫
    • Organizer
      第56回日本糖尿病学会学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 当院におけるDPP-4阻害薬の使用成績2013

    • Author(s)
      永倉 穣, 中村 昭伸, 青木 一孝, 伊藤 譲, 神子 一成, 野口 芳彦, 山川 正, 寺内 康夫
    • Organizer
      第28回日本糖尿病合併症学会
    • Place of Presentation
      旭川グランドホテル(北海道旭川市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠糖尿病にてインスリン治療が必要となった症例の臨床背景に関する検討2013

    • Author(s)
      伊藤 譲, 澁谷 誠, 吉村 公一郎, 細川 紗帆, 山本 葉子, 永田 亮, 杉浦 賢, 寺内 康夫
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病患者のロスバスタチンを投与し、厳格な脂質管理を行った際の糖脂質代謝への影響の検討2013

    • Author(s)
      亀田 晶子, 木村 真理, 井上 英昭, 野口 芳彦, 神子 一成, 瀧端 正博, 永倉 穣, 小野 香菜子, 折目 和基, 神山 博史, 宮崎 岳史, 川口 順子, 富樫 優, 白川 純, 中村 昭伸, 伊藤 譲, 青木 一孝, 寺内 康夫
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 来院後心室頻拍を発症し多臓器不全に至った甲状腺クリーゼの1 例2013

    • Author(s)
      奥山 朋子、伊藤 譲、力武  麻美、田岡 梨奈、小林 毅大、吉井 大司、室橋 裕子、山崎 俊介、富樫 優、井上 英昭、寺内 康夫
    • Organizer
      14回内分泌学会関東甲信越支部学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ステロイド・GLP-1 受容体作動薬にて治療中の糖尿病患者に認められた、インスリノーマとの鑑別が困難であった低血糖症2013

    • Author(s)
      海老澤 有紀、富樫 優、室橋 裕子、山崎 俊介、白川 純、伊藤 譲、寺内 康夫
    • Organizer
      14回内分泌学会関東甲信越支部学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 妊娠糖尿病にてインスリン治療が必要となった症例の臨床背景に関する検討2013

    • Author(s)
      伊藤 譲, 澁谷誠、細川紗帆、吉村公一郎, 山本葉子、永田亮、杉浦賢、寺内 康夫
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本市民会館(熊本)
    • Related Report
      2012 Research-status Report
  • [Presentation] インスリン治療内容が血糖コントロールおよび糖尿病合併症に及ぼす影響の比較検討 多施設後ろ向き研究2012

    • Author(s)
      宮崎 岳之, 中村 昭伸, 澁谷 誠, 青木 一孝, 伊藤 譲, 中島 茂, 木村 真理, 寺内 康夫
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Research-status Report
  • [Presentation] 副交感神経伝達物質による膵β細胞機能制御の解析2011

    • Author(s)
      伊藤譲,白川純,田波律子,折目和基,瀧端正博,田島一樹,宮崎岳之,佐藤光一郎,菊地香織,増田清美,村岡知則,富樫優,中村昭伸,土屋博久,澁谷誠,木村真理,寺内康夫
    • Organizer
      第54回日本糖尿病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 副交感神経伝達物質による膵β細胞機能制御の解析

    • Author(s)
      伊藤譲, 白川純, 田波律子, 折目和基, 瀧端正博, 田島一樹, 宮崎岳之, 佐藤光一郎, 菊地香織, 増田清美, 村岡知則, 富樫優, 中村昭伸, 土屋博久, 澁谷誠, 木村真理, 寺内康夫
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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