The role of senescence marker protein-30 (SMP30) in the progression of diabetic nephropathy
Project/Area Number |
23591317
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
HASEGAWA Goji 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00295643)
|
Co-Investigator(Kenkyū-buntansha) |
ISHIGAMI Akihito 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究副部長 (50270658)
FUKUI Michiaki 京都府立医科大学, 医学研究科, 講師 (30247829)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMAZAKI Masahiro 京都府立医科大学, 医学研究科, 助教 (50309134)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 糖尿病 / 糖尿病腎症 / 尿細管障害 / SMP30 / 糖尿病合併症 / ビタミンC |
Research Abstract |
Senescence marker protein-30 (SMP30) decreases with age and contributes to the symptoms of aging. In this study, we investigated the effect of SMP30 deficiency on the pathogenesis of diabetic nephropathy using streptozocin induced diabetic SMP30 knockout (KO) mice. Tubular damages with tubulointerstitial fibrosis were observed in non-diabetic KO mice, and diabetes exacerbated these changes. On the other hand, SMP30 deletion did not affect glomerular changes. The accumulation of HIF-1alpha, the increase of oxidative stress, and tubular inflammation were associated with tubular injuries. In conclusion, decreased SMP30 with age may contribute to the progression of diabetic nephropathy through tubular damages.
|
Report
(4 results)
Research Products
(13 results)
-
-
[Journal Article] Lepr(db/db) Mice with Senescence Marker Protein-30 Knockout (Lepr(db/db)Smp30(Y/-) ) Exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.2013
Author(s)
Kondo Y, Hasegawa G, Okada H, Senmaru T, Fukui M, Nakamura N, Sawada M, Kitawaki J, Okanoue T, Kishimoto Y, Amano A, Maruyama N, Obayashi H, Ishigami A
-
Journal Title
PLoS One
Volume: 8
Issue: 6
Pages: 65698-65698
DOI
Related Report
Peer Reviewed
-
[Journal Article] Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice2012
Author(s)
Senmaru T, Yamazaki M, Okada H, Asano M, Fukui M, Nakamura N, Obayashi H, Kondo Y, Maruyama N, Ishigami A, Hasegawa G
-
Journal Title
J Clin Biochem Nutr
Volume: 50
Pages: 114-118
NAID
Related Report
Peer Reviewed
-
-
[Presentation] Senescence marker protein-30 deficiency accelerates diabetic renal injury through tubulointerstitial fibrosis in a mouse model of type 1 diabetes2013
Author(s)
Okada H, Senmaru T, Kondo Y, Ishigami A, Obayashi H, Asano M, Yamazaki M, Fukui M, Hasegawa G, Nakamura N
Organizer
73th annual meeting and scientific sessions of American Diabetes Association
Place of Presentation
Chicago, USA
Related Report
-
-
-
-
-
[Presentation] Differential effect of vitamin C deficiency on the pathogenesis of diabetic nephropathy2012
Author(s)
Okada H, Senmaru T, Kondo Y, Ishigami A, Obayashi H, Asano M, Yamazaki M, Fukui M, Hasegawa G, Nakamura N
Organizer
72th annual meeting and scientific sessions of American Diabetes Association
Place of Presentation
Philadelphia, USA
Related Report
-
-
-