| Project/Area Number |
23591318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KISHIDA Tsunao 京都府立医科大学, 医学(系)研究科(研究院), 講師 (00370205)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Naoto 京都府立医科大学, 医学研究科, 教授 (50347449)
TAMURA Yutaka 京都府立医科大学, 医学研究科, 講師 (50263174)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 糖脂質代謝 / ﾒﾀﾎﾞﾘｯｸｼﾝﾄﾞﾛｰム / iPS細胞 / 褐色脂肪細胞 / メタボリックシンドローム / ダイレクトコンヴァージョン / ﾒﾀﾎﾞﾘｯｸｼﾝﾄﾞﾛｰﾑ |
|---|
| Research Abstract |
In rodents and other animals, brown adipocytes contribute to energy expenditure and heat production, but brown adipocytes of humans have not been characterized in detail, mainly because functional human brown adipocytes that can be propagated in culture have not been available for experimental use so far. We recently established novel procedures to induce human and murine brown adipocytes. In this study we examined gene expression profiles, epigenetic states, and metabolic activities of the brown adipocytes, while we also analyzed regulation of their activities and molecular mechanisms of their induction. The present findings have important implication to novel molecular targeting therapy against metabolic syndromes.
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