| Project/Area Number |
23591321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Saitama Medical University |
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Principal Investigator |
AWATA TAKUYA 埼玉医科大学, 医学部, 教授 (40184303)
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| Co-Investigator(Renkei-kenkyūsha) |
KURIHARA Susumu 埼玉医科大学, 医学部, 准教授 (90286104)
MORITA Tomoko 埼玉医科大学, 医学部, 講師 (40348214)
IIZUKA Hiroyuki 埼玉医科大学, 医学部, 助教 (20348246)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | １型糖尿病 / 疾患感受性遺伝子 / SNP / バリアント / GLIS3 / 日本人 / 1型糖尿病 / 感受性 / variant |
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| Research Abstract |
In Japanese, HLA class II is a very strong susceptibility factor, and the insulin gene is another confirmed susceptible locus to type 1 diabetes (T1D). We have also obtained evidence for an association with several non-HLA loci. However, it was revealed that the cumulative effect of these non-HLA susceptibility loci was much weaker than that of the HLA class II loci.
Thus, in the present study, we analyzed low-frequency variants of the non-HLA T1D candidate genes in Japanese. We first screened for protein-changing variants of 24 T1D candidate genes and then the association with T1D was tested in 706 T1D patients and 863 control subjects. In total, 56 protein-changing variants were discovered; among them, 34 were low-frequency variants. The association analysis of the low-frequency variants revealed that only the A908V variant of GLIS3 was strongly associated with resistance to T1D. This is the first report on association of low-frequency variants with T1D in non-white populations.
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