| Project/Area Number |
23591322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Tesshu 北里大学, 医学部, 助教 (60276144)
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| Co-Investigator(Renkei-kenkyūsha) |
SHICHIRI Masayoshi 北里大学, 医療系研究科, 教授 (10206097)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 糖尿病性腎症 / 腎機能 / サリューシン |
|---|
| Research Abstract |
We evaluated the Salusin-beta in 28 normal controls (C), 10 type 1 diabetic patients (T1) and 66 type 2 diabetic patients (T2) to elucidate its pathogenetic roles on diabetic nephropathy. Plasma concentration of Salusin-beta did not differ among 3 groups (C; 4.11+/-1.68 nmol/l, T1; 4.71+/-2.04, T2; 4.40+/-1.87). In all diabetic subjects, there was no significant difference of Salusin-beta between 58 normoalbuminuria (4.44+/-1.90 nmol/l) and microalbuminuria (4.42+/-1.89). Salusin-beta did not correlate with GFR measured using iohexol injection. There was no significant difference of Salusin-beta between hyperfiltration or normofiltration. In the cross-sectional study, there was no relationships between Salusin-beta and renal functional changes, i.e. albuminuria or GFR in Japanese diabetic patients. Further longitudinal study is warranted to elucidate its pathogenetic roles on diabetic nephropathy.
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