The pathogenetic role of Salusin-beta in diabetic nephropathy
| Project/Area Number |
23591322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Tesshu 北里大学, 医学部, 助教 (60276144)
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| Co-Investigator(Renkei-kenkyūsha) |
SHICHIRI Masayoshi 北里大学, 医療系研究科, 教授 (10206097)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 糖尿病性腎症 / 腎機能 / サリューシン |
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| Research Abstract |
We evaluated the Salusin-beta in 28 normal controls (C), 10 type 1 diabetic patients (T1) and 66 type 2 diabetic patients (T2) to elucidate its pathogenetic roles on diabetic nephropathy. Plasma concentration of Salusin-beta did not differ among 3 groups (C; 4.11+/-1.68 nmol/l, T1; 4.71+/-2.04, T2; 4.40+/-1.87). In all diabetic subjects, there was no significant difference of Salusin-beta between 58 normoalbuminuria (4.44+/-1.90 nmol/l) and microalbuminuria (4.42+/-1.89). Salusin-beta did not correlate with GFR measured using iohexol injection. There was no significant difference of Salusin-beta between hyperfiltration or normofiltration. In the cross-sectional study, there was no relationships between Salusin-beta and renal functional changes, i.e. albuminuria or GFR in Japanese diabetic patients. Further longitudinal study is warranted to elucidate its pathogenetic roles on diabetic nephropathy.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Clinical impacts of albuminuria and glomerular filtration rate on renal, cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.2014
Author(s)
Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
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Journal Title
Clin Exp Nephrol
Volume: -
Issue: 4
Pages: 613-620
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator2013
Author(s)
Fujimoto K, Hayashi A, Kamata Y, Ogawa A, Watanabe T, Ichikawa R, Iso Y, Koba S, Kobayashi Y, Koyama T, Shichiri M
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Journal Title
PLoS One
Volume: 8(10)
Issue: 10
Pages: e76714-e76714
DOI
Related Report
Peer Reviewed
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