Analysis of genetic basis for islet-specific autoimmunity and the applecation to prevention and treatment of type 1 diabetes

• Project/Area Number: 23591327
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kinki University
• Principal Investigator: NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
• Co-Investigator(Kenkyū-buntansha): IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062) ; KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185) ; BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: エネルギー・糖質代謝異常 / 糖尿病 / 免疫学 / 遺伝子 / 遺伝学 / インスリン / １型糖尿病 / 膵島炎 / 臓器特異的自己免疫疾患 / 関連解析 / NODマウス / type 1 diabetes / insulin / genetics

Research Abstract

Type 1 diabetes is a tissue-specific autoimmune disease against insulin-producing beta cells in pancreatic islets. To clarify the mechanisms of beta cell-specific destruction and the application of treatment for type 1 diabetes, we identified genetic factors, including Mafa gene, for islet-specific autoimmune response by association studies of candidate genes for type 1 diabetes with multiple organ-specific autoimmune diseases (type 1 diabetes, Graves' disease, Hashimoto thyroiditis and alopecia areata). Then, we established the Mafa knockout NOD mouse by speed congenic protocol. The cumulative incidence of type 1 diabetes in Mafa knockout NOD mouse was significantly protected in homozygotes of knockout allele in comparison with heterozygotes and wild type, suggesting the critical role of Mafa gene on the development of type 1 diabetes in vivo.

Research Products

• [Journal Article] Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse (2014)
  • Author(s): Wang X, Sugimoto K, Fujisawa T, Shindo N, Minato S, Kamada Y, Hamano M, Ohishi M, Ikegami H, Rakugi H
  • Journal Title: Hepatol Res Volume: 44 Pages: 102-13
  • Peer Reviewed
• [Journal Article] Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility (2014)
  • Author(s): DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
  • Journal Title: Nat Genet Volume: 46 Issue: 3 Pages: 234-246
  • DOI: 10.1038/ng.2897
  • Peer Reviewed / Open Access
• [Journal Article] Association study of MAFA and MAFB, genes related to organ-specific autoimmunity, with susceptibility to type 1 diabetes in Japanese and Caucasian populations (2013)
  • Author(s): Noso S, Kawabata Y, Babaya N, Hiromine Y, Kawasaki E, Awata T, Maruyama T, Sunanda B, Oiso N, Kawada A, Suzuki T, Eisenbarth GS, Ikegami H
  • Journal Title: J Genet Syndr Gene Ther Volume: 4 Pages: 204-204
  • Peer Reviewed
• [Journal Article] Dose effect and mode of inheritance of diabetogenic gene on mouse chromosome 11 (2013)
  • Author(s): Babaya N, Ueda H, Noso S, Hiromine Y, Nojima K, Itoi-Babaya M, Kobayashi M, Fujisawa T, Ikegami H
  • Journal Title: J Diabetes Res Volume: Article ID 608923 Pages: 6-6
  • Peer Reviewed
• [Journal Article] Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet (2013)
  • Author(s): Nojima K, Sugimoto K, Ueda H, Babaya N, Ikegami H, Rakugi H
  • Journal Title: Endocrine J Volume: 60 Pages: 261-74
  • NAID: 10031170610
  • Peer Reviewed
• [Journal Article] A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes (2013)
  • Author(s): Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Takahashi K, Kawabata Y, Kobayashi T, Nishida N, Mawatari Y; on behalf of the Japanese Study Group on Type 1 Diabetes Genetics
  • Journal Title: Biochem Biophys Res Commun Volume: 437 Pages: 521-5
  • Peer Reviewed
• [Journal Article] 円形脱毛症に併存する甲状腺および膵島自己免疫に関する臨床的・遺伝的研究 (2013)
  • Author(s): 朴忠勇、能宗伸輔、川畑由美子、山内孝哲、馬場谷成、原田剛史、廣峰義久、伊藤裕進、村田佳織、武友保憲、貫戸幸星、當間純子、末吉功治、吉田左和、大磯直毅、川田暁、池上博司
  • Journal Title: 近畿大学医学雑誌 Volume: 38(3,4) Pages: 107-114
  • Peer Reviewed
• [Journal Article] Association study of MAFA and MAFB, genes related to organ-specific autoimmunity, with susceptibility to type 1 diabetes in Japanese and Caucasian populations. (2013)
  • Author(s): Noso S, Kawabata Y, Babaya N, Hiromine Y, Kawasaki E, Awata T, Maruyama T, Sunanda B, Oiso N, Kawada A, Suzuki T, Eisenbarth GS, Ikegami H
  • Journal Title: J Genet Syndr Gene Ther Volume: 4 Issue: 11 Pages: 204-204
  • DOI: 10.4172/2157-7412.1000204
  • Peer Reviewed
• [Journal Article] A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes. (2013)
  • Author(s): Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Takahashi K, Kawabata Y, Kobayashi T, Nishida N, Mawatari Y; on behalf of the Japanese Study Group on Type 1 Diabetes Genetics.
  • Journal Title: Biochem Biophys Res Commun Volume: 437 Pages: 521-525
  • Peer Reviewed
• [Journal Article] Genome-wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India (2013)
  • Author(s): Saxena R, Yamauchi T, Hara K Saxena R, Yamauchi T, Hara K DIAGRAM MuTHER; TGEN, Kadowaki T
  • Journal Title: Diabetes Volume: 62 Issue: 5 Pages: 1746-1755
  • DOI: 10.2337/db12-1077
  • Peer Reviewed
• [Journal Article] A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans (2013)
  • Author(s): Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, Guo K, Zuo X, Guo X, Yang H, Zhou X; DIAGRAM Consortium; AGEN-T2D Consortium, Zhang X, Qi L, Loos RJ, Hu FB, Wu T, Liu Y, Liu L, Yang Z, Hu R, Jia W, Ji L, Li Y, Lin X
  • Journal Title: Diabetes Volume: 62 Issue: 1 Pages: 291-298
  • DOI: 10.2337/db12-0454
  • Peer Reviewed
• [Journal Article] １型糖尿病の体質に関する分子遺伝学的研究 (2013)
  • Author(s): 池上博司
  • Journal Title: 日本体質医学会雑誌 Volume: 75 Pages: 56-64
  • Peer Reviewed
• [Journal Article] Graves病の遺伝解析：HLA Class Iの関与 (2013)
  • Author(s): 村田佳織、川畑由美子、能宗伸輔、山内孝哲、馬場谷成、廣峰義久、伊藤裕進、朴忠勇、池上博司
  • Journal Title: 日本体質医学会雑誌 Volume: 75 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet (2013)
  • Author(s): Nojima K et al.
  • Journal Title: Endocrine J Volume: [in press]
  • Peer Reviewed
• [Journal Article] Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians (2012)
  • Author(s): Ikegami H (他名65名)
  • Journal Title: Nat Genet Volume: 44 Pages: 67-73
  • Peer Reviewed
• [Journal Article] Prolonged hyperinsulinemia after subcutaneous injection of 2400 U regular insulin in a suicide attempt : Time course of serum insulin with frequent measurements (2012)
  • Author(s): Hiromine Y, Kawabata Y, Yamauchi T, Noso S, Babaya N, Harada T, Ito H, Ikegami H
  • Journal Title: J Diabetes Invest Volume: 3 Pages: 468-470
  • Peer Reviewed
• [Journal Article] ClassIIHLA genotype in fluminant type 1 diabetes : A nationwide survey with reference to glutamic acid decarboxylase antibodies (2012)
  • Author(s): Tsutsumi C, Imagawa A, Ikegami H, Makino H, Kobayashi T, Hanafusa T, on behalf of the Japan Diabetes Society Committee on Type 1 diabetes Mellitus Research
  • Journal Title: J Diabetes Invest Volume: 3 Pages: 62-69
  • Peer Reviewed
• [Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 diabetes Mellitus : New diagnostic criteria of fluminant ytpe 1 diabetes mellitus (2012) (2012)
  • Author(s): Imagawa A, Hanafusa T, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawasaki E, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Maruyama T
  • Journal Title: J Diabetes Invest Volume: 3 Pages: 536-539
  • Peer Reviewed
• [Journal Article] Association of Genetic Variation in FTO with Risk of Obesity and Type 2 Diabetes with Date from 96,551 East and South Asians (2012)
  • Author(s): Ikegami H,(他64名)
  • Journal Title: Diabetologia Volume: 55 Pages: 981-995
  • Peer Reviewed
• [Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 diabetes Mellitus : New diagnostic criteria of fluminant ytpe 1 diabetes mellitus (2012) (2012)
  • Author(s): Imagawa A, Hanafusa T, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawasaki E, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Maruyama T
  • Journal Title: Diabetol Int Volume: 3 Pages: 179-183
  • Peer Reviewed
• [Journal Article] Prolonged hyperinsulinemia after subcutaneous injection of 2400 U regular insulin in a suicide attempt : Time course of serum insulin with frequent measurements (2012)
  • Author(s): Hiromine Y, et al
  • Journal Title: J Diabetes Invest Volume: 3 Issue: 5 Pages: 468-470
  • DOI: 10.1111/j.2040-1124.2012.00211.x
  • Peer Reviewed
• [Journal Article] Class II HLA genotype in fulminant type 1 diabetes-a nationwide survey with reference to GAD antibodies (2012)
  • Author(s): Tsutsumi C, Hanafusa T, et al
  • Journal Title: J Diabetes Investigation Volume: 3 Issue: 1 Pages: 62-69
  • DOI: 10.1111/j.2040-1124.2011.00139.x
  • Peer Reviewed
• [Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 diabetes Mellitus: New diagnostic criteria of fluminant ytpe 1 diabetes mellitus (2012) (2012)
  • Author(s): Imagawa A et al.
  • Journal Title: J Diabetes Invest Volume: 3 Issue: 6 Pages: 536-539
  • DOI: 10.1111/jdi.12024
  • Peer Reviewed
• [Journal Article] Genetics and Pathogenesis of Type 1 Diabetes : Prospects for Prevention and Intervention (2011)
  • Author(s): Ikegami H, Noso S, Babaya N, Kawabata Y
  • Journal Title: J Diabetes Invest Volume: 2 Pages: 415-420
  • Peer Reviewed
• [Journal Article] Clinical and Genetic Characteristics of Patients with Autoimmune Thyroid Disease with Anti-islet Autoimmunity (2011)
  • Author(s): Moriguchi M, Noso S, Kawabata Y, Yamauchi T, Harada T, Komaki K, Babaya N, Hiromine Y, Ito H, Yamagata S, Murata K, Higashimoto T, Park CY, Yamamoto A, Ohno Y, Ikegami H
  • Journal Title: Metabolism Volume: 60 Pages: 761-6
  • Peer Reviewed
• [Journal Article] Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals (2011)
  • Author(s): Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, Isono M, Ohnaka K, Fujisawa T, Nakashima E, Ikegami H, Nakamura J, Yamori Y, Yamaguchi S, Kobayashi S, Ogihara T, Takayanagi R, Kato N
  • Journal Title: Diabetologia Volume: 54 Pages: 1350-1359
  • Peer Reviewed
• [Journal Article] Efficacy and safety of low-dose metformin for treatment of type 2 diabetes in elderly Japanese patients (2011)
  • Author(s): Ito H, Ohno Y, Yamauchi T, Kawabata Y, Ikegami H
  • Journal Title: Geriatr Gerontol Int Volume: 11 Pages: 55-62
  • Peer Reviewed
• [Journal Article] Attenuated food anticipatory actibity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice (2011)
  • Author(s): Hayasaka N, Aoki K, Kinoshita S, Yamaguchi S, Wakelield JK, Tsuji-Kawahara S, Horikawa K, Ikegami H, Wakana S, Murakami T, Ramabhadran R, Miyazawa M, Shibata S
  • Journal Title: Pros ONE Volume: 6
  • Peer Reviewed
• [Journal Article] the Research Committee on Type 1 Diabetes of the Japan Diabetes Society : Type 1 Diabetes and Interferon Therapy : A nationwide survey in Japan (2011)
  • Author(s): Nakamura K, Kawasaki E, Imagawa A, Awata T, Ikegami H, Uchigata Y, Kobayashi T, Shimada A, Nakanishi K, Makino H, Maruyama T, Hanafusa T
  • Journal Title: Diabetes Care Volume: 34 Pages: 2084-2089
  • Peer Reviewed
• [Journal Article] Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes (2011)
  • Author(s): Yamashita H, Awata T, Kawasaki E, Ikegami H, Tanaka S, Maruyama T, Shimada A, Nakanishi K, Takahashi K, Kobayashi T, Kawabata Y, Miyashita Y, Kurihara S, Morita-Ohkubo T, Katayama S; on behalf of The Japanese Study Group on Type 1 Diabetes Genetics
  • Journal Title: Diabetes Metab Res Rev Volume: 27 Pages: 844-848
  • Peer Reviewed
• [Journal Article] Meta-analysis of genome-wide asso- ciation studies identifies eight new loci for type 2 diabetes in east Asians (2011)
  • Author(s): Cho YS, Yamauchi T, Hara K, Kadowaki T
  • Journal Title: Nature Genatics Volume: 44 Issue: 1 Pages: 67-72
  • DOI: 10.1038/ng.1019
  • Peer Reviewed
• [Journal Article] Genetics and Pathogenesis of Type 1 Diabetes : Prospects for prevention and intervention (2011)
  • Author(s): Ikegami H, et al
  • Journal Title: J Diabetes Invest Volume: 2 Issue: 6 Pages: 415-420
  • DOI: 10.1111/j.2040-1124.2011.00176.x
  • Peer Reviewed
• [Journal Article] Clinical and Genetic Characteristics of Patients with Autoimmune Thyroid Disease with Anti-islet Autoimmunity. (2011)
  • Author(s): Moriguchi M et al.
  • Journal Title: Metabolism Volume: 60 Issue: 6 Pages: 761-766
  • DOI: 10.1016/j.metabol.2010.07.025
  • Peer Reviewed
• [Journal Article] Efficacy and safety of metformin for treatment of type 2 diabetes in elderly Japanese patients (2011)
  • Author(s): Ito H, et al
  • Journal Title: Geriatr Gerontol Int Volume: 11 Issue: 1 Pages: 55-62
  • DOI: 10.1111/j.1447-0594.2010.00635.x
  • Peer Reviewed
• [Journal Article] Attenuated food anticipatory actibity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice. (2011)
  • Author(s): Hayasaka N et al.
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Type 1 Diabetes and Interferon Therapy : A nationwide survey in Japan (2011)
  • Author(s): Nakamura K, Kawasaki E, Imagawa A, Awata T, Ikegami H, Uchigata Y, Kobayashi T, Shimada A, Nakanishi K, Makino H,Maruyama T, Hanafusa T, the Research Committee on Type 1 Diabetes of the Japan Diabetes Society
  • Journal Title: Diabetes Care Volume: 34 Issue: 9 Pages: 2084-9
  • DOI: 10.2337/dc10-2274
  • Peer Reviewed
• [Journal Article] Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes. (2011)
  • Author(s): Yamashita H, Awata T, Kawasaki E, Ikegami H, Tanaka S, Maruyama T, Shimada A, Nakanishi K, Takahashi K, Kobayashi T, Kawabata Y, Miyashita Y, Kurihara S, Morita-Ohkubo T, Katayama S
  • Journal Title: Japanese Study Group on Type 1 Diabetes Genetics.DiabetesMetab Res Rev Volume: 27(8) Issue: 8 Pages: 844-8
  • DOI: 10.1002/dmrr.1234
  • Peer Reviewed
• [Journal Article] Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals (2011)
  • Author(s): Takeuchi F, et al
  • Journal Title: Diabetologia Volume: 54 Issue: 6 Pages: 1350
  • DOI: 10.1007/s00125-011-2086-8
  • URL: https://pure.teikyo.jp/en/publications/6942da84-65b3-46b9-83ad-012a2e348832
  • Peer Reviewed
• [Presentation] Mafa knockout NOD mice are protected from type 1 diabetes despite accelerated infiltration of lymphocytes into islets (2013)
  • Author(s): Noso S, Babaya N, Hiromine Y, Kawabata Y, Ikegami H
  • Organizer: 49th European Association for the Study of Diabetes Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2013-09-25
• [Presentation] Symposium 8 "Islet biology" Genetics and pathogenesis of beta-cell destruction in type 1 diabetes (2013)
  • Author(s): Ikegami H
  • Organizer: 26th Spring Congress of Korean Diabetes Association, 1st Korea-Japan Diabetes Forum
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2013-05-10
• [Presentation] A search for susceptibility genes contributing to islet-specific autoimmunity in type 1 diabetes by association studies with multiple autoimmune diseases (2013)
  • Author(s): Noso S, Kawabata Y, Babaya N, Hiromine Y, Moriguchi M, Murata K, Choongyong Park, Taketomo Y, Ikegami H
  • Organizer: 13th International Congress of the Immunology of Diabetes
  • Place of Presentation: Lorne, Australia
• [Presentation] Low expression level of Peripheral CD4+PD-1+T-cells in Japanese Patients with Type 1A Diabetes (2013)
  • Author(s): Fujisawa R, Haseda F, Tsutsumi C, Hiromine Y, Noso S, Kawabata Y, Mitsui S, Terasaki J, Ikegami H, Imagawa A, Hanafusa T
  • Organizer: 13th International Congress of the Immunology of Diabetes
  • Place of Presentation: Lorne, Australia
• [Presentation] Low Expression of PD-1 in Peripheral CD4+ T-cells in Japanese Patients with Type 1A Diabetes (2013)
  • Author(s): Fujisawa R, Haseda F, Tsutsumi C, Hiromine Y, Noso S, Kawabata Y, Mitsui S, Terasaki J, Ikegami H, Imagawa A, Hanafusa T
  • Organizer: 73rd Scientific Session of America Diabetes Association
  • Place of Presentation: Chicago, USA
• [Presentation] A search for susceptibility genes contributing to islet-specific autoimmunity in type 1 diabetes by association studies with multiple autoimmune diseases. (2013)
  • Author(s): Noso S, Kawabata Y, Babaya N, Hiromine Y, Moriguchi M, Murata K, Choongyong Park, Taketomo Y, Ikegami H
  • Organizer: 13th International Congress of the Immunology of Diabetes
  • Place of Presentation: Lorne, Australia
• [Presentation] Low expression level of Peripheral CD4+PD-1+T-cells in Japanese Patients with Type 1A Diabetes. (2013)
  • Author(s): Fujisawa R, Haseda F, Tsutsumi C, Hiromine Y, Noso S, Kawabata Y, Mitsui S, Terasaki J, Ikegami H, Imagawa A, Hanafusa T
  • Organizer: 13th International Congress of the Immunology of Diabetes
  • Place of Presentation: Lorne, Australia
• [Presentation] Basic Science 13, MDIA Symposium "GeneticsII" A search for susceptibility genes contributing to islet-specific autoimmunity in type 1 diabetes (2012)
  • Author(s): Noso S, Ikegami H
  • Organizer: 4th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2012-11-27
• [Presentation] Susceptibility genes for type 2 diabetes and related phenotypes cluster on mouse chromosome 14 (2012)
  • Author(s): Babaya N, Noso S, Hiromine Y, Ueda H, Ikegami H
  • Organizer: 48th European Association for the Study of Diabetes Annual Meeting
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2012-10-03
• [Presentation] Plenary Lecture⑫Genetics of type 1 diabetes : HLA and non-HLA genes (2012)
  • Author(s): Ikegami H
  • Organizer: ISPAD Science School for Physicians 2012 in Kyoto
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2012-09-03
• [Presentation] Association of a functional polymorphism MAFA Gly346Cys with susceptibility to type 1 diabetes (2012)
  • Author(s): Noso S, Kawabata Y, Babaya N, Hiromine Y, Kawasaki E, Awata T, Maruyama T, Babu S, Eisenbarth GS, Ikegami H
  • Organizer: 12th International Congress of the Immunology of Diabetes
  • Place of Presentation: Victoria, Canada
  • Year and Date: 2012-06-18
• [Presentation] Association of PDCD-1 (programmed cell death-1) polymorphisms in Japanese Patients with Fulminant and Type 1A diabetes (2012)
  • Author(s): Tsutsumi C, Hiromine Y, Imagawa A, Mitsui S, Noso S, Kawabata Y, Terasaki J, Ikegami H, Hanafusa T
  • Organizer: 12th International Congress of the Immunology of Diabetes
  • Place of Presentation: Victoria, Canada
  • Year and Date: 2012-06-18
• [Presentation] A search for susceptibility genes contributing to islet-specific autoimmunity in type 1 diabetes (2012)
  • Author(s): Noso S et al.
  • Organizer: 4th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] Association of a functional polymorphism MAFA Gly346Cys with susceptibility to type 1 diabetes. (2012)
  • Author(s): Noso S et al.
  • Organizer: 12th International Conference on the Immunology of Diabetes
  • Place of Presentation: Victoria, Canada
• [Presentation] Genetics of type 1 diabetes: HLA and non-HLA genes (2012)
  • Author(s): Ikegami H
  • Organizer: ISPAD Science School for Physicians 2012 in Kyoto
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] Susceptibility genes for type 2 diabetes and related phenotypes cluster on mouse chromosome 14. (2012)
  • Author(s): Babaya N et al.
  • Organizer: 48th European Association for the Study of Diabetes Annual Meeting
  • Place of Presentation: Berlin, Germany
• [Presentation] Association of PDCD-1 (programmed cell death-1) polymorphisms in Japanese Patients with Fulminant and Type 1A diabetes. (2012)
  • Author(s): Tsutsumi C et al.
  • Organizer: 12th International Conference on the Immunology of Diabetes
  • Place of Presentation: Victoria, Canada
• [Presentation] Susceptibility to insulin resistance, adiposity and obesity is mapped to proximal region of mouse chromosome 14 (2011)
  • Author(s): Babaya N, Noso S, Hiromine Y, Kobayashi M, Ueda H, Ikegami H
  • Organizer: The 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-10-21
• [Presentation] Main Symposium 5 / Type 1diabetes in East Asia「Genetics of Type 1 diabetes in East Asia」 (2011)
  • Author(s): Ikegami H
  • Organizer: The 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-10-21
• [Presentation] Heterogenetiy of classIIHLA genotypes in patients with fulminant type 1 diabetes in Japan (2011)
  • Author(s): Tsutsumi C, Imagawa A, Ikegami H, Makino H, Kobayashi T, Hanafusa T
  • Organizer: The 3rd Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Beijing, China
• [Presentation] Genetics of Type 1 diabetes in East Asia (2011)
  • Author(s): Ikegami H
  • Organizer: The 16th Japan-Korea Symposium on Diabetes Mellitus(招待講演)
  • Place of Presentation: Hilton Tokyo Bay (Tokyo)
• [Presentation] Susceptibility to insulin resistance, adiposity and obesity is mapped to proximal region of mouse chromosome 14. (2011)
  • Author(s): Naru Babaya et al.
  • Organizer: The 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Hilton Tokyo Bay (Tokyo)
• [Presentation] Heterogenetiy of class II HLA genotypes in patients with fulminant type 1 diabetes in Japan (2011)
  • Author(s): Tsutsumi C et al.
  • Organizer: The 3rd Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Beijing International Convention Center (China)
• [Presentation] Genetics and pathogenesis of beta-cell destruction in type 1 diabetes
  • Author(s): Ikegami H
  • Organizer: 26th Spring Congress of Korean Diabetes Association, 1st Korea-Japan Diabetes Forum
  • Place of Presentation: Jeju, Korea
  • Invited
• [Presentation] １型糖尿病の遺伝因子：免疫寛容の破綻と標的臓器へのターゲティング
  • Author(s): 池上博司
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] １型糖尿病関連遺伝子研究の進歩
  • Author(s): 川畑由美子、能宗伸輔、池上博司
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] 糖尿病発症における体質と環境
  • Author(s): 池上博司
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] １型糖尿病の原因を探る：なぜ膵β細胞だけが破壊されるのか?
  • Author(s): 池上博司
  • Organizer: 第48回糖尿病学の進歩
  • Place of Presentation: 札幌
  • Invited
• [Presentation] １型糖尿病濃厚発症家系におけるrare variant の探索
  • Author(s): 川畑由美子、能宗伸輔、馬場谷成、廣峰義久、貴志明生、前川 聡、池上博司
  • Organizer: 第11回１型糖尿病研究会
  • Place of Presentation: 軽井沢
• [Presentation] 1 型糖尿病の遺伝因子：免疫寛容の破綻と膵β 細胞へのターゲティング
  • Author(s): 池上博司、川畑由美子、能宗伸輔
  • Organizer: 第11回１型糖尿病研究会
  • Place of Presentation: 軽井沢
  • Invited
• [Presentation] Graves病の遺伝子解析：HLAクラスIIとクラスIの関与
  • Author(s): 村田佳織、川畑由美子、山内孝哲、能宗伸輔、馬場谷成、原田剛史、廣峰義久、伊藤裕進、武友保憲、池上博司
  • Organizer: 第110回日本内科学会総会・講演会
  • Place of Presentation: 東京
• [Presentation] 甲状腺中毒性周期性四肢麻痺患者におけるKCNJ18遺伝子の分子遺伝学的解析
  • Author(s): 能宗伸輔、山内孝哲、馬場谷成、原田剛史、廣峰義久、伊藤裕進、村田佳織、朴忠勇、武友保憲、貫戸幸星、當間純子、川畑由美子、池上博司
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] １型糖尿病の成因：膵β細胞特異性を規定する遺伝因子の解明とその制御
  • Author(s): 能宗伸輔、池上博司
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 自然発症２型糖尿病モデルNSYマウスにおける糖尿病発症率の性差と血中アディポサイトカイン濃度との関連
  • Author(s): 上田裕紀, 馬場谷成, 能宗伸輔, 大石（久永）裕子, 上田（西脇）由美子, 若菜 茂晴, 川畑由美子, 池上博司
  • Organizer: 第28回日本糖尿病・肥満動物学会
  • Place of Presentation: 宮崎
• [Book] 今日の治療指針 2014年版 (2014)
  • Author(s): 池上博司
  • Total Pages: 2014
  • Publisher: 医学書院
• [Book] 糖尿病 UP・DATE 賢島セミナー 糖尿病療養のイノベーション (2013)
  • Author(s): 池上博司
  • Total Pages: 269
  • Publisher: 時事通信社
• [Book] 糖尿病の分子標的と治療薬事典 (2013)
  • Author(s): 能宗伸輔、池上博司
  • Total Pages: 342
  • Publisher: 羊土社
• [Book] 糖尿病 最新の治療 2013-2015 (2013)
  • Author(s): 廣峰義久、池上博司
  • Total Pages: 354
  • Publisher: 南江堂
• [Book] ブリットル糖尿病の病態と治療・管理のコツ －進化する治療・広がる未来－ (2012)
  • Author(s): 能宗伸輔 他
  • Publisher: 医歯薬出版
• [Book] 最新臨床糖尿病学（上）糖尿病学の最新動向 (2012)
  • Author(s): 川畑由美子 他
  • Publisher: 羊土社
• [Book] Series モデル動物利用マニュアル 疾患モデルの作製と利用 糖尿病・肥満/感染症 (2012)
  • Author(s): 馬場谷成 他
  • Publisher: LIFE-SCIENCE INFORMATION CENTER
• [Book] カラー版 内科学 (2012)
  • Author(s): 川畑由美子 他
  • Publisher: 西村書店
• [Book] 糖尿病学2011「胸腺における新たなインスリン発現調節因子としてのMafAの役割と1型糖尿病発症への関与」 (2011)
  • Author(s): 能宗伸輔、池上博司
  • Publisher: 診断と治療社
• [Book] 糖尿病学 2011 (2011)
  • Author(s): 能宗伸輔 他
  • Publisher: 診断と治療社
• [Remarks]
  • URL: http://emdm.med.kindai.ac.jp/index.php
• [Remarks] 近畿大学医学部内分泌・代謝・糖尿病内科ホームページ 研究の内容の概説
  • URL: http://emdm.med.kindai.ac.jp/content/index.php