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Identification and characterization of susceptibility genes for type 1 diabetes in the major histocompatibility complex

Research Project

Project/Area Number 23591328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionKinki University

Principal Investigator

KAWABATA Yumiko  近畿大学, 医学部, 准教授 (80423185)

Co-Investigator(Kenkyū-buntansha) IKEGAMI Hiroshi  近畿大学, 医学部, 教授 (20221062)
NOUSOU Shinsuke  近畿大学, 医学部, 講師 (90460849)
BABAYA Naru  近畿大学, 医学部, 講師 (10449837)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords1型糖尿病 / 遺伝子 / HLA / 1型糖尿病
Research Abstract

To clarify genetic susceptibility to type 1 diabetes in the major histocompatibility complex , we robustly investigated the association of HLA-DRB1, DQB1, A, B, C loci with type 1 diabetes. This study showed that the frequency of the combination of DRB1*04:05-DQB1*04:01 and DRB1*08:02-DQB1*03:02 was low in Japanese population, but this was very high risk combination to type 1 diabetes. Several alleles of B, C loci were associated with type 1 diabetes, but most of them appeared to be secondary to linkage disequilibrium between these alleles and disease-related class II alleles. Taken the result with autoimmune thyroid disease in consideration, these data suggest that HLA Class II and Class I might contribute to the genetic susceptibility in the different manner, for each specific target organ.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (56 results)

All 2014 2013 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results,  Open Access: 1 results) Presentation (31 results)

  • [Journal Article] Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility2014

    • Author(s)
      Ikegami H(他331名)
    • Journal Title

      Nat Genet

      Volume: 46 Pages: 234-244

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility2014

    • Author(s)
      DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
    • Journal Title

      Nat Genet

      Volume: 46 Issue: 3 Pages: 234

    • DOI

      10.1038/ng.2897

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association study of MAFA and MAFB, genes related to organ-specific autoimmunity, with susceptibility to type 1 diabetes in Japanese and Caucasian populations2013

    • Author(s)
      Noso S, Kawabata Y,(他11名)
    • Journal Title

      J Genet Syndr Gene Ther

      Volume: 4 Pages: 204-204

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes2013

    • Author(s)
      Kawabata Y(他
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437 Pages: 521-525

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet2013

    • Author(s)
      Babaya N(他5名)
    • Journal Title

      Endocr J

      Volume: 60 Pages: 261-74

    • NAID

      10031170610

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of MAFA and MAFB, genes related to organ-specific autoimmunity, with susceptibility to type 1 diabetes in Japanese and Caucasian populations.2013

    • Author(s)
      Noso S, Kawabata Y, Babaya N, Hiromine Y, Kawasaki E, Awata T, Maruyama T, Sunanda B, Oiso N, Kawada A, Suzuki T, Eisenbarth GS, Ikegami H
    • Journal Title

      J Genet Syndr Gene Ther

      Volume: 4 Issue: 11 Pages: 204-204

    • DOI

      10.4172/2157-7412.1000204

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes.2013

    • Author(s)
      Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Takahashi K, Kawabata Y, Kobayashi T, Nishida N, Mawatari Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437 Issue: 4 Pages: 521-525

    • DOI

      10.1016/j.bbrc.2013.06.102

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Graves病の遺伝子解析:HLA Class Iの関与2013

    • Author(s)
      村田佳織、川畑由美子、能宗伸輔、山内孝哲、馬場谷成、廣峰義久、伊藤裕進、朴忠勇、池上博司
    • Journal Title

      日本体質医学会雑誌

      Volume: 75 Pages: 74-74

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 家系内に自己免疫性甲状腺疾患が多発し、多腺性自己免疫症候群III-A型に骨髄異形成症候群を合併した1例2013

    • Author(s)
      日高周次、川畑由美子、中山俊之、加島尋、光冨公彦、石田健朗、藤富豊、野口仁志、福永淳治、池上博司、吉松博信
    • Journal Title

      糖尿病

      Volume: 56 Pages: 15-15

    • NAID

      10031170446

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies identifies 8 new loci for type 2 diabetes in East Asians2012

    • Author(s)
      Ikegami H(他67名)
    • Journal Title

      Nature Genet

      Volume: 44 Pages: 67-72

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus : New diagnostic criteria of fulminant type 1 diabetes mellitus(2012)2012

    • Author(s)
      Kawabata Y(他14名)
    • Journal Title

      J Diabetes Invest

      Volume: 3 Pages: 536-539

    • NAID

      10030590043

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus : New Diagnostic Criteria of Fulminant Type 1 Diabetes Mellitus(2012)2012

    • Author(s)
      Kawabata Y(他14名)
    • Journal Title

      J Diabetes Invest

      Volume: 3 Pages: 179-183

    • NAID

      10030590043

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged hyperinsulinemia after subcutaneous injection of 2400 U regular insulin in a suicide attempt : Time course of serum insulin with frequent measurements2012

    • Author(s)
      Kawabata Y(他7名
    • Journal Title

      J Diabetes Invest

      Volume: 3 Pages: 468-470

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic variation in FTO with risk of obesity and type 2 diabetes in up to 96,551 East and South Asians2012

    • Author(s)
      Ikegami H(他64名)
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 981-95

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ClassIIHLA genotype in fulminant type 1 diabetes : A nationwide survey with reference to glutamic acid decarboxylase antibodies2012

    • Author(s)
      Ikegami H(他5名)
    • Journal Title

      J Diabetes Invest

      Volume: 3 Pages: 62-69

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New Diagnostic Criteria of Fulminant Type 1 Diabetes Mellitus(2012)2012

    • Author(s)
      Imagawa A, Hanafusa T, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawasaki E, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Maruyama T
    • Journal Title

      Diabetology International

      Volume: 3 Issue: 4 Pages: 179-179

    • DOI

      10.1007/s13340-012-0098-3

    • NAID

      10030590043

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetics and pathogenesis of type 1 diabetes : prospects for prevention and intervention2011

    • Author(s)
      Ikegami H, Noso S, Babaya N, Kawabata Y
    • Journal Title

      J Diabetes Invest

      Volume: 2 Pages: 415-420

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes2011

    • Author(s)
      Kawabata Y(他14名)
    • Journal Title

      Diabetes Metab Res Rev

      Volume: 27 Pages: 844-848

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Type 1 diabetes and interferon therapy : a nationwide survey in Japan2011

    • Author(s)
      Ikegami H(他11名)
    • Journal Title

      Diabetes Care

      Volume: 34 Pages: 2084-2089

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity2011

    • Author(s)
      Kawabata Y(他15名)
    • Journal Title

      Metabolism

      Volume: 60 Pages: 761-766

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic variants for susceptibility to obesity with type 2 diabetes in the Japanese individuals2011

    • Author(s)
      Ikegami H(他17名)
    • Journal Title

      Diabetologia

      Volume: 54 Pages: 1350-1359

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes.2011

    • Author(s)
      Yamashita H, Awata T, Kawasaki E, Ikegami H, Tanaka S, Maruyama T, Shimada A, Nakanishi K, Takahashi K, Kobayashi T, Kawabata Y, Miyashita Y, Kurihara S, Morita-Ohkubo T, Katayama S
    • Journal Title

      Japanese Study Group on Type 1 Diabetes Genetics.DiabetesMetab Res Rev

      Volume: 27(8) Issue: 8 Pages: 844-8

    • DOI

      10.1002/dmrr.1234

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical and Genetic Characteristics of Patients with Autoimmune Thyroid Disease with Anti-islet Autoimmunity.2011

    • Author(s)
      Moriguchi M et al.
    • Journal Title

      Metabolism

      Volume: 60 Issue: 6 Pages: 761-766

    • DOI

      10.1016/j.metabol.2010.07.025

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetics and Pathogenesis of Type 1 Diabetes: Prospects for prevention2011

    • Author(s)
      Ikegami H et al.
    • Journal Title

      J Diabetes Invest

      Volume: 2 Pages: 415-420

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dose Effect and Mode of Inheritance of Diabetogenic Gene on Mouse Chromosome 11

    • Author(s)
      Babaya N(他8名)
    • Journal Title

      J Diabetes Res

      Volume: (Epub 2013 Feb 25) Pages: 2013-2013

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] A search for susceptibility genes contributing to islet-specific autoimmunity in type 1 diabetes by association studies with multiple autoimmune diseases2013

    • Author(s)
      Kawabata Y(他8名)
    • Organizer
      13th International Congress of the Immunology of Diabetes Society
    • Place of Presentation
      Australia
    • Year and Date
      2013-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Low expression level of Peripheral CD4+PD-1+T-cells in Japanese Patients with Type 1A Diabetes2013

    • Author(s)
      Kawabata Y(他10名)
    • Organizer
      13th International Congress of the Immunology of Diabetes Society
    • Place of Presentation
      Australia
    • Year and Date
      2013-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 1型糖尿病濃厚発症家系におけるrare variantの探索2013

    • Author(s)
      川畑由美子(他6名)
    • Organizer
      第11回1型糖尿病研究会
    • Place of Presentation
      長野
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 甲状腺中毒性周期性四肢麻痺の遺伝子解析:KCNJ18遺伝子の関与2013

    • Author(s)
      能宗伸輔、川畑由美子(他9名)
    • Organizer
      第63回日本体質医学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2013-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Mafa knockout NOD mice are protected from type 1 diabetes despite accelerated infiltration of lymphocytes into islets2013

    • Author(s)
      Kawabata Y(他4名)
    • Organizer
      49th European Association for the Study of Diabetes Annual Meeting
    • Place of Presentation
      Spain
    • Year and Date
      2013-09-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Low Expression of PD-1 in Peripheral CD4+ T-Cells in Japanese Patients with Type 1A Diabetes2013

    • Author(s)
      Kawabata Y(他10名)
    • Organizer
      73rd Scientific Sessions of America Diabetes Association
    • Place of Presentation
      USA
    • Year and Date
      2013-06-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 1型糖尿病関連遺伝子研究の進歩2013

    • Author(s)
      川畑由美子(他2名)
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Graves病の遺伝解析:HLAクラスIIとクラスIの関与2013

    • Author(s)
      川畑由美子(他9名)
    • Organizer
      第110回日本内科学会総会・講演会
    • Place of Presentation
      東京
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] NSYマウス第11番染色体に存在する糖尿病・ストレプトゾトシン感受性遺伝子のdose effectならびに遺伝様式の解析2013

    • Author(s)
      馬場谷成(他4名)
    • Organizer
      第27回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-02-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Graves病の遺伝子解析:HLA ClassIの関与2012

    • Author(s)
      川畑由美子(他9名)
    • Organizer
      第62回日本体質医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Susceptibility genes for type 2 diabetes and related phenotypes cluster on mouse chromosome 142012

    • Author(s)
      Babaya N(他4名)
    • Organizer
      48th European Association for the Study of Diabetes Annual Meeting
    • Place of Presentation
      Germany
    • Year and Date
      2012-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Association of PDCD-1 (programmed cell death-1) Polymorphisms in Japanese Patients with Fulminant and Type 1A Diabetes2012

    • Author(s)
      Kawabata Y(他8名)
    • Organizer
      12th International Conference on the Immunology of Diabetes
    • Place of Presentation
      Canada
    • Year and Date
      2012-06-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Association of a functional polymorphism MAFA Gly346Cys with susceptibility to type 1 diabetes2012

    • Author(s)
      Kawabata Y(他9名)
    • Organizer
      12th International Conference on the Immunology of Diabetes
    • Place of Presentation
      Canada
    • Year and Date
      2012-06-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 急性発症1型糖尿病の発症年齢とHLAクラスIIハプロタイプとの関連:日本糖尿病学会1型糖尿病調査研究委員会による多施設共同研究2012

    • Author(s)
      川畑由美子(他25名)
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      神奈川
    • Year and Date
      2012-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫疾患の臓器特異性:円形脱毛症と自己免疫性甲状腺疾患における膵島自己免疫の臨床的・遺伝的比較2012

    • Author(s)
      川畑由美子(他14名)
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      神奈川
    • Year and Date
      2012-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫性甲状腺疾患の遺伝子解析:HLA Class Iの関与2012

    • Author(s)
      川畑由美子(他14名)
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      愛知
    • Year and Date
      2012-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 臓器特異的自己免疫疾患の共通性と異質性:円形脱毛症に合併する甲状腺および膵島自己免疫の実態と遺伝解析2012

    • Author(s)
      川畑由美子(他9名)
    • Organizer
      第109回日本内科学会総会・講演会
    • Place of Presentation
      京都
    • Year and Date
      2012-04-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Association of PDCD-1 (programmed cell death-1) polymorphisms in Japanese Patients with Fulminant and Type 1A diabetes.2012

    • Author(s)
      Tsutsumi C, Hiromine Y, Imagawa A, Mitsui S, Noso S, Kawabata Y, Terasaki J, Ikegami H, Hanafusa T
    • Organizer
      12th International Conference on the Immunology of Diabetes
    • Place of Presentation
      Victoria (Canada)
    • Related Report
      2012 Research-status Report
  • [Presentation] Association of a functional polymorphism MAFA Gly346Cys with susceptibility to type 1 diabetes.2012

    • Author(s)
      Noso S, Kawabata Y, Babaya N, Hiromine Y, Kawasaki E, Awata T, Maruyama T, Babu S, Eisenbarth GS, Ikegami H
    • Organizer
      12th International Conference on the Immunology of Diabetes
    • Place of Presentation
      Victoria (Canada)
    • Related Report
      2012 Research-status Report
  • [Presentation] 急性発症1型糖尿病の発症年齢とHLAクラスIIハプロタイプとの関連:日本糖尿病学会1型糖尿病調査研究委員会による多施設共同研究2012

    • Author(s)
      川畑由美子、池上博司、粟田卓也ほか
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] 甲状腺中毒性周期性四肢麻痺患者におけるKCNJ18遺伝子の新規多型検索2011

    • Author(s)
      川畑由美子(他10名)
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫疾患の臓器特異性:円形脱毛症における膵島自己免疫の実態と遺伝解析―甲状腺自己免疫との比較―2011

    • Author(s)
      川畑由美子(他15名)
    • Organizer
      第9回1型糖尿病研究会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Susceptibility to insulin resistance, adiposity and obesity is mapped to proximal region of mouse chromosome 142011

    • Author(s)
      Babaya N(他5名)
    • Organizer
      The 16th Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫疾患の臓器特異性を規定する体質に関する検討:円形脱毛症に合併する甲状腺および膵島自己免疫の実態と遺伝解析2011

    • Author(s)
      川畑由美子(他11名)
    • Organizer
      第61回日本体質医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Heterogeneity of classIIHLA genotypes in patients with fulminant type 1 diabetes in Japan2011

    • Author(s)
      Ikegami H(他6名)
    • Organizer
      The 3rd Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      China
    • Year and Date
      2011-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 円形脱毛症患者における甲状腺および膵島自己免疫疾患合併例の検討2011

    • Author(s)
      川畑由美子(他17名)
    • Organizer
      第84回日本内分泌学会学術集会
    • Place of Presentation
      兵庫
    • Year and Date
      2011-04-23
    • Related Report
      2013 Final Research Report
  • [Presentation] A search for susceptibility genes contributing to islet-specific autoimmunity in type 1 diabetes by association studies with multiple autoimmune diseases

    • Author(s)
      Noso S, Kawabata Y, Babaya N, Hiromine Y, Moriguchi M, Murata K, Park C, Taketomo Y, Ikegami H
    • Organizer
      13th International Congress of the Immunology of Diabetes Society
    • Place of Presentation
      Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] 1型糖尿病濃厚発症家系におけるrare variantの探索

    • Author(s)
      川畑由美子、能宗伸輔、馬場谷成、廣峰義久、貴志明生、前川聡、池上博司
    • Organizer
      第11回1型糖尿病研究会
    • Place of Presentation
      長野
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mafa knockout NOD mice are protected from type 1 diabetes despite accelerated infiltration of lymphocytes into islets

    • Author(s)
      Noso S, Babaya N, Hiromine Y, Kawabata Y, Ikegami H
    • Organizer
      49th European Association for the Study of Diabetes Annual Meeting
    • Place of Presentation
      Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] 1型糖尿病関連遺伝子研究の進歩

    • Author(s)
      川畑由美子、能宗伸輔、池上博司
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Graves病の遺伝解析:HLAクラスIIとクラスIの関与

    • Author(s)
      村田佳織、川畑由美子、山内孝哲、能宗伸輔、馬場谷成、原田剛史、廣峰義久、伊藤裕進、武友保憲、池上博司
    • Organizer
      第110回日本内科学会総会・講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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