Genome-wide analysis of epigenomic alterations in pancreatic islets from mice under the risk of developing glucose intolerance
Project/Area Number |
23591330
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Research Institute, International Medical Center of Japan |
Principal Investigator |
NAMMO Takao 独立行政法人国立国際医療研究センター, 代謝疾患研究部, 室長 (50594115)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | エネルギー・糖質代謝異常 / エピジェネティクス / 2型糖尿病 / 環境因子 / ヒストン修飾 / 膵ランゲルハンス島 / インスリン分泌 / 遺伝子発現 / エネルギー・糖代謝異常 / 膵ベータ細胞 / ゲノム網羅的解析 / マウスモデル |
Research Abstract |
Both genetic and environmental factors play important roles in the aetiology of diabetes, although the molecular mechanisms underlying the disease remain largely unclear. These days, epigenetic regulation of gene expression, which results from changes in a chromosome without alterations in the DNA sequence, has drawn attention to the field of diabetes research. The aim of this study was to clarify the involvement of epigenetic mechanisms in the regulation of pancreatic beta-cell function and glucose metabolism by genome-wide analyses. By testing mouse models, such as diet-induced obese mice and spontaneously diabetic mice, we found the cis-regulatory regions exhibited changes in the epigenome that were characteristic for the model. Furthermore, these effects were associated with changes in the expression of overlapping or adjacent genes. In summary, these results suggest the importance of genome-wide study of epigenome for clarifying disease mechanisms and identifying new drug targets.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.2014
Author(s)
Pasquali L, Gaulton KJ, Rodriguez-Segui SA, Mularoni L, Miguel-Escalada I, Akerman I, Tena JJ, Moran I, Gomez-Marin C, van de Bunt M, Ponsa-Cobas J, Castro N, Nammo T, Cebola I, Garcia-Hurtado J, Maestro MA, Pattou F, Piemonti L, Berney T, Gloyn AL, Ravassard P, Gomez-Skarmeta JL, Muller F, McCarthy MI, Ferrer J.
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Journal Title
Nat Genet.
Volume: 46
Issue: 2
Pages: 136-143
DOI
Related Report
Peer Reviewed
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[Journal Article] Quantitative assessment of pdx1 promoter activity in vivo using a secreted luciferase reporter system.2013
Author(s)
Nishimura, W., Eto, K., Miki, A., Goto, M., Kawaguchi, M., Nammo, T., Udagawa, H., Hiramoto, M., Shimizu, Y., Okamura, T., Fujiwara, T., Yasuda, Y. and Yasuda, K.
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Journal Title
Endocrinology
Volume: 154
Issue: 11
Pages: 4388-4395
DOI
Related Report
Peer Reviewed
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