| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Nuclear hormone receptors play fundamental roles in development, differentiation, and energy homeostasis in a body and require a variety of transcriptional coregulators to exert their function. We recently isolated PDIP1, a novel coregulator of peroxisome proliferator-activated receptor gamma and found that PDIP1 knockout mice are protected against high-fat diet-induced obesity and fatty liver. In the present study, we examined the mechanism underlying the anti-obesity effect of PDIP1 deficiency. In addition, we identified a novel coregulator that interacts with PDIP1 and analyzed its role in adipocyte differentiation.
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