| Project/Area Number |
23591337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Ehime University (2013)
Kumamoto University (2011-2012) |
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Principal Investigator |
YOSHINAGA Kayo 愛媛大学, 医学部附属病院, 助教 (10537088)
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| Co-Investigator(Kenkyū-buntansha) |
ARAKI Eiichi 熊本大学, 大学院生命科学研究部, 教授 (10253733)
MATSUMURA Takeshi 熊本大学, 医学部付属病院, 講師 (20398192)
ISHII Norio 熊本大学, 医学部付属病院, 医員 (10599111)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 脂質代謝異常 |
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| Research Abstract |
The aim of the study is to investigate whether overexpression of COX-2 induces PPARs-dependent anti-atherogenic action in macrophages and macrophage-specific COX-2 transgenic mice. We revealed that overexpression of COX-2 induced intracellular ligand-dependent activation of PPARs in macrophages. Moreover, LPS-induced expression of TNF-alpha, MCP-1 and MMP-9 were down-regulated, and expression of ABCA-1 and ABCG1 were up-regulated in COX-2-overexpressed macrophages. Furthermore, we next prepared the macrophage-specific COX-2 transgenic mice. Now, we are genetically confirming the succession of the preparing of the mice.
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