Effect of overexpression of COX-2 on the progression of atherosclerosis via activation of PPARs in macrophages
| Project/Area Number |
23591337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Ehime University (2013)
Kumamoto University (2011-2012) |
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Principal Investigator |
YOSHINAGA Kayo 愛媛大学, 医学部附属病院, 助教 (10537088)
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| Co-Investigator(Kenkyū-buntansha) |
ARAKI Eiichi 熊本大学, 大学院生命科学研究部, 教授 (10253733)
MATSUMURA Takeshi 熊本大学, 医学部付属病院, 講師 (20398192)
ISHII Norio 熊本大学, 医学部付属病院, 医員 (10599111)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂質代謝異常 |
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| Research Abstract |
The aim of the study is to investigate whether overexpression of COX-2 induces PPARs-dependent anti-atherogenic action in macrophages and macrophage-specific COX-2 transgenic mice. We revealed that overexpression of COX-2 induced intracellular ligand-dependent activation of PPARs in macrophages. Moreover, LPS-induced expression of TNF-alpha, MCP-1 and MMP-9 were down-regulated, and expression of ABCA-1 and ABCG1 were up-regulated in COX-2-overexpressed macrophages. Furthermore, we next prepared the macrophage-specific COX-2 transgenic mice. Now, we are genetically confirming the succession of the preparing of the mice.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling2014
Author(s)
Uchimura K, Hayata M, Mizumoto T, Miyasato Y, Kakizoe Y, Morinaga J, Onoue T, Yamazoe R, Ueda M, Adachi M, Miyoshi T, Shiraishi N, Ogawa W, Fukuda K, Kondo T, Matsumura T, Araki E, Tomita K, Kitamura K
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Journal Title
Nat Commun
Volume: 5
Pages: 3428-3428
Related Report
Peer Reviewed
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[Journal Article] Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages2013
Author(s)
Kinoshita H, Matsumura T, Ishii N, Fukuda K, Senokuchi T, Motoshima H, Kondo T, Taketa K, Kawasaki S, Hanatani S, Takeya M, Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun
Volume: 431
Pages: 124-130
Related Report
Peer Reviewed
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[Journal Article] Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes2013
Author(s)
Matsumura T, Taketa K, Motoshima H, Senokuchi T, Ishii N, Kinoshita H, Fukuda K, Yamada S, Kukidome D, Kondo T, Hisada A, Katoh T, Shimoda S, Nishikawa T, Araki E
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Journal Title
Cardiovasc Diabetol
Volume: 12
Pages: 177-177
Related Report
Peer Reviewed
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[Journal Article] Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.2013
Author(s)
Miyagawa K, Kondo T, Goto R, Matsuyama R, Ono K, Kitano S, Kawasaki S, Igata M, Kawashima J, Matsumura T, Motoshima H, Araki E.
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Journal Title
Cardiovascular Diabetology
Volume: 12(1)
Issue: 1
Pages: 160-160
DOI
Related Report
Peer Reviewed
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[Journal Article] Telmisartan exerts antiatherosclerotic effects by activating peroxisome proliferator-activated receptor-γin macrophages2011
Author(s)
Matsumura T, Kinoshita H, Ishii N, Fukuda K, Motoshima H, Senokuchi T, Taketa K, Kawasaki S, Nishimaki-Mogami T, Kawada T, Nishikawa T, Araki E
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31
Pages: 1268-1275
Related Report
Peer Reviewed
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[Journal Article] Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice2011
Author(s)
Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun
Volume: 404
Pages: 339-344
Related Report
Peer Reviewed
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[Presentation] 肥満症例におけるインスリン頻回注射療法からGLP-1受容体作動薬への変更による短・中期的効果の検討2012
Author(s)
渡辺栄一郎, 下田誠也, 古川昇, 河島淳司, 瀬ノ口隆文, 竹田佳代, 岩下晋輔, 久木留大介, 井形元維, 石井規夫, 前田貴子, 阪口雅司, 荒木栄一
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
パシフィコ横浜，パンパシフィック横浜ベイホテル東急（神奈川）
Related Report
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[Presentation] 2型糖尿病の脂質管理におけるピタバスタチンの有用性の検討2011
Author(s)
竹田佳代,松村剛,嶋田さやか,水流添覚,本島寛之,近藤龍也,久木留大介,古川昇,下田誠也,宮村信博,西川武志,荒木栄一
Organizer
第54回日本糖尿病学会総会
Place of Presentation
札幌
Related Report
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[Presentation] 2型糖尿病の脂質管理におけるピタバスタチンの有用性の検討.2011
Author(s)
竹田佳代, 松村剛, 嶋田さやか, 水流添 覚, 本島寛之, 近藤龍也, 久木留大介, 古川 昇, 下田誠也, 宮村信博, 西川武志, 荒木栄一
Organizer
第54回日本糖尿病学会総会
Place of Presentation
札幌
Related Report
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