| Project/Area Number |
23591342
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
HIRASE Tetsuaki 独立行政法人国立循環器病研究センター, 研究所, 室長 (60363446)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MORISAKI Takayuki 独立行政法人国立循環器病研究センター, 研究所, 部長 (30174410)
MORISAKI Hiroko 独立行政法人国立循環器病研究センター, 研究所, 室長 (40311451)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | amp deaminase / 骨格筋 / インスリン抵抗性 / AMP deaminase |
|---|
| Research Abstract |
Insulin resistance is a key factor in the pathogenic mechanisms of diabetes. We have studied the function of AMPD1, an isoform of AMP catalyzing enzyme AMP deaminase, which is preferentially expressed in skeletal muscles and potentially modifies insulin signaling pathway, in the glucose and lipid metabolism by analyzing AMPD1-deficient mice. We demonstrate that AMPD1 deficiency improves impaired glucose tolerance and insulin resistance induced by high fat diet challenge. Gene expression profiles in skeletal muscles were modified by AMPD1 deficiency during high fat diet challenge. Although further studies are necessary to elucidate the targets of AMPD1 in insulin signaling pathway, these data suggest that AMPD1 inhibition could be a therapeutic strategy against diabetes.
|
