| Project/Area Number |
23591343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Tohoku University |
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Principal Investigator |
ITOI Keiichi 東北大学, 情報科学研究科, 教授 (60232427)
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| Co-Investigator(Kenkyū-buntansha) |
FUSE Toshimitsu 東北大学, 大学院情報科学研究科, 助教 (50401039)
UCHIDA Katsuya 東北大学, 大学院情報科学研究科, 助教 (40344709)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOKAWA Hiroshi 東北福祉大学, 健康学部, 教授 (30227467)
SAKIMURA Kenji 新潟大学, 脳研究所, 教授 (40162325)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | ノルアドレナリン / ストレス / 視床下部 / 副腎皮質ホルモン / 脳幹部 / 神経ペプチド / バゾプレシン / CRF / 延髄 / ペプチド / 自律神経 / 電気生理 / ラット / マウス / プロラクチン放出ペプチド |
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| Research Abstract |
Prolactin-releasing peptide (PrRP) is colocalized with noradernaline (NA) in the medulla. We examined whether PrRP and/or NA are involved in activation of neuroendocrine neurons, including corticotropin-releasing factor (CRF) neurons,in the paraventricular nucleus of the hypothalamus (PVN). It was demonstrated that PrRP-containing NA neurons are activated by stress, and that NA and PrRP work in a cooperative manner in the PVN. Using a PVN slice of the CRF-Venus konckin mouse, it was shown that NA stimulates CRF neurons via glutamatergic inputs.
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