| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To elucidate the aromatase inhibitor (AI)-resistant mechanism, we established 6 kinds of resistant cell lines having different resistant mechanisms from ERE-GFP introduced MCF-7 cells which we established previously. These resistant cells were established by long-term estrogen depletion and/or androgen supplemented under monitoring ERE-GFP activity. The characterization of these cell lines revealed novel hormonal therapy-resistant mechanisms such as ligand-independent ER activation by phosphorylation from PI3K-Akt pathway, ER activation by estrogen-like androgen metabolite (3bHSD), or androgen receptor-dependent growth mechanism.
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