Physiological diversity of cytosolic T3 binding protein.: Relationship between inflammation and low T3 syndrome
| Project/Area Number |
23591349
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Fukushima Medical University (2013)
Shinshu University (2011-2012) |
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Principal Investigator |
SUZUKI Satoru 福島県立医科大学, 医学部, 教授 (30222061)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 甲状腺ホルモン / ホルモン輸送 / 細胞質 / クリスタリン / NADPH / crym / mu-crystallin / thyroid hormone / T3 / inflammation / 細胞質甲状腺ホルモン結合蛋白 / 甲状腺ホルモン応答遺伝子 / 低酸素 / LPS / 炎症 / ノックアウトマウス |
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| Research Abstract |
1. To elucidate the mechanisms of its expression, we evaluated the promoter transactivity and insulin signaling via the AP-1 site in the promoter.The results indicated that the expression of mu-crystallin was regulated through the AP-1 site in the promoter. The signals related to AP-1 activation, such as insulin signaling may have diverse effects on mu-crystallin mRNA expression. .
2.To examine the precise regulation of T3-responsive genes in the presence of CRYM, we evaluated serial alterations of T3-responsive gene expression by changing pericellular T3 concentrations in the media.The results suggest that CRYM expression increases and sustains the T3 responsiveness of genes in cells, especially with alteration of the pericellular T3 concentration.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells2014
Author(s)
Takeshige K, Sekido T, Kitahara JI, Ohkubo Y, Hiwatashi D, Ishii H, Nishio SI, Takeda T, Komatsu M, Suzuki S.
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Journal Title
Endocrine Journal
Volume: 61
Issue: 6
Pages: 561-570
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
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