Identification and functional analysis of novel markers for thyroid cancer stem cells
Project/Area Number |
23591357
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Nagasaki University |
Principal Investigator |
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 甲状腺 / 癌幹細胞 / 甲状腺癌 / 癌 |
Outline of Final Research Achievements |
Cancer stem-like cells (CSCs) play important roles in cancer initiation, recurrence, and metastasis. In the present study, we conducted a comprehensive search for thyroid CSC markers. Expression of cell surface markers and ALDH activity, which are CSC markers in various solid cancers, and the ability to form spheres in vitro as an indicator of tumor-initiating ability were investigated using thyroid cancer cell lines. As a result, ALDH activity seems to be a major candidate marker for thyroid CSCs but not universal. Other markers such as CD326 and CD44 may be important depending on individual cases.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] The Common Genetic Variant rs944289 on Chromosome 14q13.3 Associates with Risk of Both Malignant and Benign Thyroid Tumors in the Japanese Population2015
Author(s)
Rogounovitch TI, Bychkov A, Takahashi M, Mitsutake N, Nakashima M, Nikitski AV, Hayashi T, Hirokawa M, Ishigaki K, Shigematsu K, Bogdanova T, Matsuse M, Nishihara E, Minami S, Yamanouchi K, Ito M, Kawaguchi T, Kondo H, Takamura N, Ito Y, Miyauchi A, Matsuda F, Yamashita S, Saenko VA
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Journal Title
Thyroid
Volume: 25
Pages: 330-40
NAID
Related Report
Peer Reviewed
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[Journal Article] Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAFV600E-induced thyroid tumors in a mouse model.2014
Author(s)
Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, Kurashige T, Suzuki K, Saenko V, Nagayama Y, Yamashita S, Mitsutake N
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Journal Title
Thyroid
Volume: 24(3)
Issue: 3
Pages: 502-510
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma2013
Author(s)
Shimamura M, Nakahara M, Orim F, Kurashige T, Mitsutake N, Nakashima M, Kondo S, Yamada M, Taguchi R, Kimura S, Nagayama Y
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Journal Title
Endocrinology
Volume: 154
Issue: 11
Pages: 4423-30
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAFV600E mutation status.2013
Author(s)
Mussazhanova Z, Matsuda K, Naruke Y, Mitsutake N, Stanojevic B, Rogounovitch T, Saenko V, Suzuki K, Nishihara E, Hirokawa M, Ito M, Nakashima M.
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Journal Title
HIstopathology
Volume: 63
Issue: 5
Pages: 726-734
DOI
Related Report
Peer Reviewed
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