| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Cancer stem-like cells (CSCs) play important roles in cancer initiation, recurrence, and metastasis. In the present study, we conducted a comprehensive search for thyroid CSC markers. Expression of cell surface markers and ALDH activity, which are CSC markers in various solid cancers, and the ability to form spheres in vitro as an indicator of tumor-initiating ability were investigated using thyroid cancer cell lines. As a result, ALDH activity seems to be a major candidate marker for thyroid CSCs but not universal. Other markers such as CD326 and CD44 may be important depending on individual cases.
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