Mining of novel granin-derived bioactive peptides that regulate insulin secretion.
Project/Area Number |
23591358
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | University of Miyazaki |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TOSHINAI Koji 宮崎大学, 医学部, 講師 (80381101)
松尾 崇 宮崎大学, 医学部, その他 (10404427)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 生理活性ペプチド / 糖尿病 / インスリン / 膵β細胞 |
Research Abstract |
To explore the physiological roles of NERP-2 in the pancreas, we examined its effects on insulin secretion. We detected NERP-2 immunoreactivity in pancreatic islets, where it co-localized extensively with insulin. NERP-2 increased glucose-stimulated insulin secretion (GSIS) in a dose-dependent manner from isolated mouse pancreatic islets. NERP-2 significantly augmented GSIS after administration to rodents. Neither NERP-1 nor NERP-2-Gly (non-amidated NERP-2) stimulated insulin secretion. Calcium-imaging analysis demonstrated that NERP-2 increased the calcium influx in MIN6 cells. These findings show that NERP-2 is a novel bioactive peptide to stimulate insulin secretion.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro2012
Author(s)
Yamaguchi H, Moin AH, Rhee M ,Kim JW, Toshinai K, Waise TMZ, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
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Journal Title
Biochem Biophys Res Commun
Volume: 428
Pages: 512-517
Related Report
Peer Reviewed
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[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro.2012
Author(s)
Moin AS, Yamaguchi H, Rhee M, Kim JW, Toshinai K, Waise TM, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
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Journal Title
Biochem Biophys Res Commun
Volume: 428
Issue: 4
Pages: 512-517
DOI
Related Report
Peer Reviewed
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