| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Obesity increases the risk of developing metabolic disorders. The detailed pathogenic mechanism of inflammation in obesity is not fully understood. Low-molecular-mass polypeptide-7 (LMP7) is a proteolytic subunit of the immunoproteasome that plays a fundamental role in the immune system, and has been involved in the pathogenesis of several autoimmune diseases. We investigated the role of LMP7 in obesity using LMP7-deficient mice. LMP7 deficiency showed resistance to obesity, suppressed macrophage accumulation in adipose tissue, improved glucose tolerance, and suppressed serum triglyceride level elevation induced by high-fat diet (HFD) feeding, which increased fecal lipid contents. Using bone-marrow-transferred chimeric mice, we found that LMP7 in both hematopoietic and non-hematopoietic cells had critical roles in HFD-induced obesity development. These findings demonstrate that LMP7 in both hematopoietic and non-hematopoietic cells contributes to the pathogenesis of obesity.
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