| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Steroid hormones act reversibly or irreversibly in every developmental stage. With regard to the biological environmental adaptation of an organism, the action of the steroid is one of the most interesting phenomena. The steroid hormones take important role that is to function expression of central nervous system. In rodents, the substantial sex differences of the brain are performed by estrogen action in a perinatal period. Meanwhile, since the expression of aromatase gene increases transiently in a perinatal period, it is conceivable that the program of the transcriptional regulation of aromatase gene is deeply concerned with the sexual differentiation of the brain. In this study, to elucidate of the sex differentiation of the brain, I analyzed the transcription factors that take part in the control of the brain-specific expression of the aromatase gene.
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