| Project/Area Number |
23591365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Akita University |
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Principal Investigator |
TAKAHASHI Naoto 秋田大学, 医学(系)研究科(研究院), 講師 (80344753)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
TAGAWA Hiroyuki 秋田大学, 大学院医学系研究科, 講師 (30373492)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | CML / miRNA / miR-200c / Bmi-1 / microRNA / 骨髄性白血病 / 慢性骨髄性白血病 |
|---|
| Research Abstract |
To detect specific miRNA in cancer stem cell of chromic myelogenious leukemia (CML), we established CML mice (B6) which can develop CML. We got cancer stem cells from B6 mice and examined miRNA expression from KLS population. We found that several miRNA were up-or down regulated in these mice. For instance, down regulation of miR-203,miR-200c, miR-26,miR-21,miR-2105, and miR-181. In this time we are examining targets of these miRNAs. We identified Bmi-1 is possible target of miR-200c in CML stem cells. And we fort her demonstrated that bortezomib was effective for diminishing CML stem cells by targeting both Bmi-1 and miR-200c.
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