Molecular mechanism of MLL mutant-induced MDS
| Project/Area Number |
23591367
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
SASHIDA Goro 千葉大学, 医学(系)研究科(研究院), 助教 (70349447)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IWAMA Atsushi 千葉大学, 大学院医学研究院, 教授 (70244126)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | MLL-PTD / RUNX1 / 骨髄異形成症候群 / 急性骨髄性白血病 / 国際情報交換 / MDS / エピジェネティクス / 造血幹細胞 |
|---|
| Research Abstract |
Given that MLL-PTD regulates the expression of RUNX1 mutants at protein level, we generated a novel MDS/AML mouse model by utilizing MLL-PTD knock-in mouse and Runx1 heterozygous mouse or RUNX1 mutants. We also demonstrated how MLL-PTD and RUNX1 mutants collaborated to induce the development of MDS and promote AML following MDS.
|
Report
(4 results)
Research Products
(13 results)
-
-
-
-
-
-
-
-
-
-
[Presentation] Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells2012
Author(s)
Yue Zhang, Xiaomei Yan, Goro Sashida, Xinghui Zhao, Yalan Rao, Susumu Goyama, Susan Whitman, Nicholas Zorko, Kelsie M. Bernot, Rajeana M. Conway, David Witte, Qianfei Wang, Daniel G Tenen, Zhijian Xiao, Guido Marcucci, James C. Mulloy, H. Leighton Grimes, Michael A. Caligiuri, and Gang Huang
Organizer
アメリカ血液学会
Place of Presentation
アトランタ、米国(Blood 2012; 120: 3501)
Year and Date
2012-12-08
Related Report
-
-
-
[Presentation] MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion2011
Author(s)
Yue Zhang, Xiaomei Yan, Goro Sashida, Xinghui Zhao, Yalan Rao, Susumu Goyama, Susan P. Whitman, Nicholas Zorko, Kelsie M. Bernot, David Witte, Qian-fei Wang, Daniel G. Tenen, Zhijian Xiao, Guido Marcucci, James C. Mulloy, Michael A Caligiuri, and Gang Huang
Organizer
アメリカ血液学会
Place of Presentation
サンディエゴ、米国(Blood 2011; 118: 2801)
Year and Date
2011-12-10
Related Report
