Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Research Abstract |
STAT proteins are transcription factors that mediate cell proliferation and differentiation. Aberrant signals of STAT are strongly involved in cancer. We demonstrated that a novel STAT inhibitor, OPB-31121, strongly inhibited STAT3 and STAT5 phosphorylation, and induced significant growth inhibition in various hematopoietic malignant cells. OPB-31121 was particularly effective against leukemia harboring BCR-ABL, FLT3/ITD, and JAK2 V617F. We showed the significant anti-tumor effect of OPB-31121 against human leukemia cells using patient-derived xenograft model.
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