Effects of FGF2 on the leukemia microenvironment in the bone marrow
Project/Area Number |
23591382
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Aichi Medical University (2012-2013) Nagoya University (2011) |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
NAOE Tomoki 名古屋医療センター, 血液内科, 院長 (50217634)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 血液腫瘍学 / 血液悪性腫瘍幹細胞 / ニッチェ / 血液学 / 腫瘍微小環境 / ケモカイン / 白血病ニッチェ |
Research Abstract |
We examined effects of FGF2 on interaction between leukemia cells and its microenvironment. Significantly fewer AML cells were recovered from cocultures with murine stromal monolayers treated with FGF2 than from control. FGF2 also facilitate the sensitivity of CML cells toward imatinib in the coculture. Accordingly, AML cells in cell cycle quiescent are less in FGF2-treated monolayers than control. We next treated human AML mouse model with Ara-C in combination w/wo FGF2. BM sections from FGF2-treated mice displayed thickened bone trabeculae and an increased number of leukemia cells compared to control. FGF2 did not help leukemia cells survive from Ara-C in the spleen. These observations suggest that the endosteal region consisting of osteoblasts is important for leukemia cells to survive from chemotherapy, and that FGF2 favors leukemia cell in the BM via promoting osteoblast functions.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions2014
Author(s)
Satoshi Nishiwaki, Takayuki Nakayama, Makoto Murata, Tetsuya Nishida, Seitaro Terakura, Shigeki Saito, Tomonori Kato, Hiroki Mizuno, Nobuhiko Imahashi, Aika Seto, Yukiyasu Ozawa, Koichi Miyamura, Masafumi Ito, Kyosuke Takeshita, Hidefumi Kato, Shinya Toyokuni, Keisuke Nagao, Ryuzo Ueda, and Tomoki Naoe
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Journal Title
PLOS one
Volume: 9(5)
Issue: 5
Pages: e96252-e96252
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone.2014
Author(s)
Inaba H, Takeshita K, Uchida Y, Hayashi M, Okumura T, Hirashiki A, Yoshikawa D, Ishii H, Yamamoto K, Nakayama T, Hirayama M, Matsumoto H, Matsushita T, Murohara T
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Journal Title
PLOS one
Volume: 9(1)
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment.2011
Author(s)
Iwase A, Goto M, Manabe S, Hirokawa W, Kobayashi H, Nakahara T, Takikawa S, Kotani T, Sumigama S, Tsuda H, Nakayama T, Suzuki N, Matsushita T, Kikkawa F.
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Journal Title
Fertil Steril.
Volume: 95
Related Report
Peer Reviewed
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[Presentation] Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-12014
Author(s)
Uchida Y, Takeshita K, Yamamoto K, Kikuchi R, Nakayama T, Nomura M, Cheng XW, Egashira K, Matsushita T, Nakamura H, Murohara T.
Organizer
Keystone symposia
Place of Presentation
BC, Canada
Related Report
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