Roles for RUNX1/AML1 in DNA damage-repair pathway
Project/Area Number |
23591385
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Kobe Shoin Women's University (2012-2013) Osaka University (2011) |
Principal Investigator |
SATOH Yusuke 神戸松蔭女子学院大学, 人間科学部, 准教授 (20506307)
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Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 医学系研究科, 教授 (20177489)
ORITANI Kenji 大阪大学, 医学系研究科, 教授 (70324762)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | RUNX1 / MDS / AML / DNA損傷 / 骨髄異形成症候群 / 造血幹細胞 / DNA修復 |
Research Abstract |
We found that the C-terminal deletion mutant of RUNX1 attenuates DNA-damage repair responses in hematopoietic stem/progenitor cells. Bone marrow cells from MDS/AML patients harboring the RUNX1-C-terminal mutation showed significantly lower levels of GADD45A expression compared with those from MDS/AML patients with wild-type RUNX1. As for this mechanism, we found that RUNX1 directly regulates the transcription of GADD45A. These results suggest Gadd45a dysfunction due to RUNX1 mutations can cause additional mutation(s) required for multi-step leukemogenesis.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages2013
Author(s)
Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y
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Journal Title
Immunity
Volume: 38
Pages: 1105-1115
Related Report
Peer Reviewed
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[Journal Article] The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.2013
Author(s)
Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y.
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Journal Title
Immunity
Volume: 38
Issue: 6
Pages: 1105-1115
DOI
Related Report
Peer Reviewed
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[Journal Article] The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and selfrenewal2012
Author(s)
Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y
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Journal Title
Journal of Immunology
Volume: 189
Pages: 200-210
Related Report
Peer Reviewed
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[Journal Article] NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells2012
Author(s)
Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y
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Journal Title
Biochem Biophys Res Commun
Volume: 418
Pages: 811-817
Related Report
Peer Reviewed
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[Presentation] Endothelial Cell-Selective Adhesion Molecule Marks Human Hematopoietic Stem Cells Regardless Of The HSC Sources2013
Author(s)
Ishibashi T, Yokota T, Ichii M, Satoh Y, Sudo T, Doi Y, Fujita N, Nagate Y, Hamanaka Y, Matsui K, Tanimura A, Saitoh N, Ezoe S, Shibayama H, Kincade PW, Oritani K, Kanakura Y
Organizer
The American Society of Hematology 55th Annual Meeting
Place of Presentation
ニューオリンズ
Year and Date
2013-12-08
Related Report
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[Presentation] Endothelial Cell-Selective Adhesion Molecule Marks Human Hematopoietic Stem Cells Regardless Of The HSC Sources2013
Author(s)
Ishibashi T, Yokota T, Ichii M, Satoh Y, Sudo T, Doi Y, Fujita N, Nagate Y, Hamanaka Y, Matsui K, Tanimura A, Saitoh N, Ezoe S, Shibayama H, Kincade PW, Oritani K, Kanakura Y
Organizer
55th ASH Annual Meeting and Exposition
Place of Presentation
New Orleans
Related Report
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[Presentation] An Anti-Apoptotic Molecule, Anamorsin, Is Essential for Erythropoiesis Through the Regulation of Cellular Labile Iron Pool2012
Author(s)
Tanimura A, Hamanaka Y, Fujita N, Doi Y,Ishibashi T, Sudo T, Matsui K, Ichii M, Saitoh N, Satoh Y, Ezoe S, Yokota T, Oritani K, Shibayama H, Kanakura Y
Organizer
The American Society of Hematology 54th Annual Meeting
Place of Presentation
アトランタ
Year and Date
2012-12-10
Related Report
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[Presentation] Satb1 promotes hematopoietic stem cell differentiation toward the lymphoid lineages2011
Author(s)
Satoh Y, Yokota T, Kondo M, Lai A, Kincade P, Kouro T, Iida R, Kokame K, Miyata T, Sudo T, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y
Organizer
The American Society of Hematology 53rd Annual Meeting
Place of Presentation
サンディエゴ
Year and Date
2011-12-12
Related Report
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[Presentation] Satb1 promotes hematopoietic stem cell differentiation toward the lymphoid lineages.2011
Author(s)
Satoh Y, Yokota T, Kondo M, Lai A, Kincade P, Kouro T, Iida R, Kokame K, Miyata T, Sudo T, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y.
Organizer
The American Society of Hematology 53rd Annual Meeting
Place of Presentation
San Diego convention center (San Diego, USA)
Related Report
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[Presentation] An Anti-Apoptotic Molecule, Anamorsin, Is Essential for Erythropoiesis Through the Regulation of Cellular Labile Iron Pool
Author(s)
Tanimura A, Hamanaka Y, Fujita N, Doi Y, Ishibashi T, Sudo T, Matsui K, Ichii M, Saitoh N, Satoh Y, Ezoe S, Yokota T, Oritani K, Shibayama H, Kanakura Y.
Organizer
The American Society of Hematology 54th Annual Meeting.
Place of Presentation
Georgia World Congress Center (Atlanta USA)
Related Report