The role of HIF-1a in the development of lymphoproliferative diseases in transgenic mouse model

• Project/Area Number: 23591393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Saga University
• Principal Investigator: SUEOKA Eizaburo 佐賀大学, 医学部, 教授 (00270603)
• Co-Investigator(Kenkyū-buntansha): ARAGANE Naoko 佐賀大学, 医学部, 講師 (20321846) ; 出 勝 佐賀大学, 医学部, 助教 (00398124)
• Co-Investigator(Renkei-kenkyūsha): IDE Masaru 佐賀大学, 医学部, 助教 (00398124)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 低酸素応答 / HIF-1 / リンパ腫 / 造血幹細胞 / がん幹細胞 / 薬剤耐性 / Lymphoma / hypoxia / transgenic mouse / BCR-ABL / CML / 低酸素応答遺伝子 / 幹細胞 / アポトーシス

Research Abstract

Hypoxia-inducible factor-1alfa (HIF-1 alfa) plays an important role in the induction of various genes under hypoxic condition. We investigate the role of HIF-1 alfa in tumor development and metastasis, and established transgenic mice constitutively expressing HIF-1A gene under regulation of the cytomegalovirus gene promoter. HIF-1 alfa protein levels varied among organs, but the expression of HIF-1 alfa mRNA gradually increased in an age-dependent manner. The transgenic mice developed tumors in the lymphoid, lung, and breast; the most prominent tumor was lymphoma appearing in the intestinal mucosa and intra-mesenchymal tissues. The lymphocytes of the transgenic mice revealed prolonged survival under long-term culture conditions and revealed increased resistance to cytotoxic drugs. These results suggest that HIF-1 alfa play an important role in lymphomagenesis mediated through the prolonged survival of lymphocytes in this transgenic mouse model.

Research Products

• [Journal Article] Therapeutic management in cardiac lymphoma (2014)
  • Author(s): Yoshihara M, Itamura H, Fukushima N, Itoh M, Furukawa K, Nagatomo D, Kamachi K, Kitamura H, Shindo T, Kubota Y, Sueoka E, Morita S, Ichinohe T, Kimura S
  • Journal Title: Leuk Lymphoma Volume: 55 Pages: 1215-7
  • Peer Reviewed
• [Journal Article] 電子カルテと輸血管理システムの連携による輸血後鉄過剰症モニタリングプログラムの運用とその課題 (2014)
  • Author(s): 末岡榮三朗、山田尚友、山田麻里江、久保田寧、吉村麻里子、板村英和、出勝、横尾眞子、吉原麻里、蒲池和晴、北村浩晃、進藤岳郎、安藤寿彦、小島研介、東谷孝徳、木村晋也
  • Journal Title: 日本輸血細胞治療学会誌 Volume: 60 Pages: 12-17
  • NAID: 130004542705
  • Peer Reviewed
• [Journal Article] 抗M(IgM+IgG)において抗体価測定時に反応増強剤無添加間接抗グロブリン試験で一部陰性を示した妊婦の1例 (2014)
  • Author(s): 山田麻里江、山田尚友、久保田寧、木村晋也、東谷孝徳、末岡榮三朗
  • Journal Title: 日本輸血細胞治療学会誌 Volume: 60 Pages: 32-37
  • NAID: 130004542708
  • Peer Reviewed
• [Journal Article] Direct identification method for bacteria in positive blood culture bottles using MALDI biotyper (2013)
  • Author(s): Uki N, Oho M, Nagasawa Z, Higashitani T, Ohta S, Sueoka E, Miyamoto H
  • Journal Title: Rinsho Byori Volume: 61(3) Pages: 224-30
  • NAID: 10031171348
  • Peer Reviewed
• [Journal Article] Tumor promoters : from chemicals to inflammatory proteins (2013)
  • Author(s): Fujiki H, Sueoka E, Suganuma M
  • Journal Title: J Cancer Res Clin Oncol Volume: 139(10) Pages: 1603-14
  • Peer Reviewed
• [Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival (2013)
  • Author(s): Sueoka E , Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K
  • Journal Title: PLoS One Volume: 8(4)
  • Peer Reviewed
• [Journal Article] 輸血後鉄過剰症の現状と問題点 (2013)
  • Author(s): 末岡榮三朗、山田尚友、山田麻里江、久保田寧、浦田千紗子、吉村麻里子、板村英和、久富崇、福島伯泰、出勝、横尾眞子、吉原麻里、蒲池和晴、北村浩晃、進藤岳郎、一戸辰夫、東谷孝徳、木村晋也
  • Journal Title: 日本輸血細胞治療学会誌 Volume: 59 Pages: 73-78
  • NAID: 10031165492
  • Peer Reviewed
• [Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival. (2013)
  • Author(s): Sueoka E, Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K
  • Journal Title: PLoS One Volume: 8 Issue: 4 Pages: e57833-e57833
  • DOI: 10.1371/journal.pone.0057833
  • Peer Reviewed
• [Journal Article] Tumor promoters: from chemicals to inflammatory proteins. (2013)
  • Author(s): Fujiki H, Sueoka E, Suganuma M.
  • Journal Title: J Cancer Res Clin Oncol Volume: 139 Issue: 10 Pages: 1603-1614
  • DOI: 10.1007/s00432-013-1455-8
  • Peer Reviewed
• [Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival. (2013)
  • Author(s): Sueoka E, Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K.
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbαto support adhesion to von Willebrand factor and collagen (2012)
  • Author(s): Takata Y, Kanaji T, Moroi M, Seki R, Sano M, Nakazato S, Sueoka E, Imamura Y, Okamura T
  • Journal Title: Int J Hematol Volume: 96 Pages: 733-42
  • Peer Reviewed
• [Journal Article] Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma (2012)
  • Author(s): Katsuya H, Yamanaka T, Ishitsuka K, Utsunomiya A, Sasaki H, Hanada S, Eto T, Moriuchi Y, Saburi Y, Miyahara M, Sueoka E, Uike N, Yoshida S, Yamashita K, Tsukasaki K, Suzushima H, Ohno Y, Matsuoka H, Jo T, Suzumiya J, Tamura K
  • Journal Title: J Clin Oncol Volume: 30 Pages: 1635-40
  • Peer Reviewed
• [Journal Article] Successful reduced-intensity umbilical cord blood transplant for fulminant hemophagocytic syndrome in an adult with pre-existing rheumatoid arthritis and autoimmune hemolytic anemia (2012)
  • Author(s): Itamura H, Fukushima N, Kondo S, Urata C, Tanaka-Yoshimura M, Yokoo M, Ide M, Hisatomi T, Kubota Y, Sueoka E, Ichinohe T, Kimura S
  • Journal Title: Leuk Lymphoma Volume: 53 Pages: 2307-9
  • Peer Reviewed
• [Journal Article] Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients (2012)
  • Author(s): Tanaka A, Sueoka-Aragane N, Nakamura T, Takeda Y, Mitsuoka M, Yamasaki F, Hayashi S, Sueoka E, Kimura S
  • Journal Title: Lung Cancer Volume: 75 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Successful reduced-intensity umbilical cord blood transplant for fulminant hemophagocytic syndrome in an adult with pre-existing rheumatoid arthritis and autoimmune hemolytic anemia. (2012)
  • Author(s): Itamura H, Fukushima N, Kondo S, Urata C, Tanaka-Yoshimura M, Yokoo M, Ide M, Hisatomi T, Kubota Y, Sueoka E, Ichinohe T, Kimura S
  • Journal Title: Leuk Lymphoma Volume: 53 Issue: 11 Pages: 2307-2309
  • DOI: 10.3109/10428194.2012.680453
  • Peer Reviewed
• [Journal Article] Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma (2012)
  • Author(s): Katsuya H, Yamanaka T, Ishitsuka K, et al.
  • Journal Title: J Clin Oncol. Volume: 30 Issue: 14 Pages: 1635-1640
  • DOI: 10.1200/jco.2011.38.2101
  • Peer Reviewed
• [Journal Article] Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbα to support adhesion to von Willebrand factor and collagen (2012)
  • Author(s): Yuka Takata et al
  • Journal Title: Int J Hematol Volume: 96(6) Issue: 6 Pages: 733-742
  • DOI: 10.1007/s12185-012-1216-5
  • Peer Reviewed
• [Journal Article] Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients. (2012)
  • Author(s): Tanaka A, Sueoka-Aragane N, Nakamura T, Takeda Y, Mitsuoka M, Yamasaki F, Hayashi S, Sueoka E, Kimura S
  • Journal Title: Lung Cancer Volume: 75 Issue: 1 Pages: 89-94
  • DOI: 10.1016/j.lungcan.2011.06.004
  • Peer Reviewed
• [Journal Article] A noninvasive system for monitoring resistance to epidermal growth factor receptor tyrosine kinase inhibitors with plasma DNA. (2012)
  • Author(s): Nakamura T, Sueoka-Aragane N, Iwanaga K, Sato A, Komiya K, Abe T, Ureshino N, Hayashi S, Hosomi T, Hirai M, Sueoka E, Kimura S
  • Journal Title: J Thorac Oncol 6:1639-48 Volume: 6 Issue: 10 Pages: 1639-1648
  • DOI: 10.1097/jto.0b013e31822956e8
  • Peer Reviewed
• [Journal Article] Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA. (2012)
  • Author(s): Nakamura T, Sueoka-Aragane N, Iwanaga K, Sato A, Komiya K, Kobayashi N, Hayashi S, Hosomi T, Hirai M, Sueoka E, Kimura S
  • Journal Title: J Thorac Oncol Volume: 7 Issue: 9 Pages: 1369-1381
  • DOI: 10.1097/jto.0b013e31825f2821
  • Peer Reviewed
• [Journal Article] Influences of %T>MIC achievement probability due to the difference of the MIC measurement concentration range-analysis of meropenem for Pseudomonas aerugin (2012)
  • Author(s): Nagasawa Z, Nakashima Y, Fukutomi Y, Uki N, Kusaba K, Nagumo F, Ohta S, Sueoka E, Miyamoto H.
  • Journal Title: Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi (Japanese). Volume: 22 Pages: 11-22
  • Peer Reviewed
• [Journal Article] 質量分析装置MALDIバイオタイパーを使用した各種ATCC株による同定精度の評価および血液培養ボトルからの直接迅速同定法の有用性に関する検討 (2012)
  • Author(s): 宇木望、永沢善三、草場耕二、福富由美子、末岡榮三朗、宮本比呂志
  • Journal Title: 臨床と微生物 Volume: 39 Pages: 97-107
  • Peer Reviewed
• [Journal Article] Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type : the NK-cell Tumor Study Group (NKTSG) study (2011)
  • Author(s): Yamaguchi M, Kwong Y, Kim K, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
  • Journal Title: J Clin Oncol Volume: 29 Pages: 4410-6
  • Peer Reviewed
• [Journal Article] Influences of %T>MIC achievement probability due to the difference of the MIC measurement concentration range-analysis of meropenem for Pseudomonas aeruginosa (2011)
  • Author(s): Nagasawa Z, Nakashima Y, Fukutomi Y, Uki N, Kusaba K, Nagumo F, Ohta S, Sueoka E, Miyamoto H
  • Journal Title: Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi Volume: 22 Pages: 11-22
  • Peer Reviewed
• [Journal Article] Clinical presentation and outcome in patients of over 75 years old with malignant lymphoma (2011)
  • Author(s): Fukushima N, Itamura H, Urata C, Tanaka M, Hisatomi T, Kunota Y, Sueoka E, Kimura S
  • Journal Title: Int J Clin Med Volume: 2 Pages: 246-253
  • Peer Reviewed
• [Journal Article] Lenalidomide in combination with dexamethasone induced rhabdomyolysis in a multiple myeloma patient treated with pravastatin (2011)
  • Author(s): Urata C, Yoshimura M, Itamura H, Hisatomi T, Kubota Y, Fukushima N, Sueoka E, Kimura S
  • Journal Title: Int J Hematol Volume: 94 Pages: 216-7
• [Journal Article] A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA (2011)
  • Author(s): Nakamura T, Sueoka-Aragane N, Iwanaga K, Sato A, Komiya K, Abe T, Ureshino U, Hayashi S, Hosomi, Hirai M, Sueoka E, Kimura S
  • Journal Title: J Thorac Oncol Volume: 6 Pages: 1639-48
  • Peer Reviewed
• [Journal Article] A fully integrated, automated and rapid detection system for KRAS mutations (2011)
  • Author(s): Ureshino N, Sueoka-Aragane N, Nakamura T, Sato A, Komiya K, Iwanaga K, Mitsuoka M, Takeda Y, Hayashi S, Sueoka E, Kimura S
  • Journal Title: Oncol Rep Volume: 26 Pages: 609-13
  • Peer Reviewed
• [Journal Article] A fully integrated and automated detection system for single nucleotide polymorphisms of UGT1A1 and CYP2C19 (2011)
  • Author(s): Ureshino N, Aragane N, Nakamura T, Ide M, Mochinaga S, Fukushima N, Hayashi S, Sueoka E, Kimura S
  • Journal Title: Oncol Res Volume: 19 Pages: 111-4
  • Peer Reviewed
• [Journal Article] NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase IIa and DNA-dependent protein kinase (2011)
  • Author(s): Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kurimasa A, Okamoto K, Kimura S, Sueoka E
  • Journal Title: Blood Volume: 117 Pages: 3575-84
  • Peer Reviewed
• [Journal Article] NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cellsby inhibition of dual targets on topoisomerase II{alpha}c and DNA-dependent protein kinase. (2011)
  • Author(s): Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kurimasa A, Okamoto K, Kimura S and Sueoka E
  • Journal Title: Blood Volume: 117(13) Issue: 13 Pages: 3575-84
  • DOI: 10.1182/blood-2010-02-270439
  • Peer Reviewed
• [Journal Article] Lenalidomide in combination with dexamethasone induced rhabdomyolysis in a multiple myeloma patient treated with pravastatin. (2011)
  • Author(s): Urata C, Yoshimura M, Itamura H, Hisatomi T, Kubota Y, Fukushima N, Sueoka E, Kimura S.
  • Journal Title: Int J Hematol Volume: 94 Issue: 2 Pages: 216-217
  • DOI: 10.1007/s12185-011-0903-y
  • Peer Reviewed
• [Journal Article] Fully Integrated, Automated and Rapid Detection System for KRAS Mutations. (2011)
  • Author(s): Ureshino N, Sueoka-Aragane N, Nakamura T, Sato A, Komiya K, Iwanaga K, Mitsuoka M, Takeda Y, Hayashi S, Sueoka E, Kimura S.
  • Journal Title: Oncol Rep Volume: 26 Pages: 609-613
  • DOI: 10.3892/or.2011.1341
  • Peer Reviewed
• [Journal Article] Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type : The NK-cell Tumor Study Group (NKTSG) study (2011)
  • Author(s): Yamaguchi M, et al
  • Journal Title: Journal of Clinical Oncology Volume: 29(33) Issue: 33 Pages: 4410-4416
  • DOI: 10.1200/jco.2011.35.6287
  • Peer Reviewed
• [Presentation] Establishment of a rapid and automated detection system for BRAF mutations in malignant melanoma (2013)
  • Author(s): Masaru Ide, Shinichi Koba, Yumi Nagano, Naoko Aragane-Sueoka, Akemi Sato, Takuya Inoue, Naomi Kobayashi, Noriyuki Misago, Yutaka Narisawa,Shinya Kimura, Eisaburo Sueoka
  • Organizer: AACR Annual Meeting 2013
• [Presentation] Development of animal model mimicking metastasis of human lung cancers using NOJ/SCID mice (2013)
  • Author(s): Naoko Sueoka-Aragane, Akemi Sato, Naomi Kobayashi, Masaru Ide, Eisaburo Sueoka, Seiji Okada, Shinya Kimura
  • Organizer: AACR Annual Meeting 2013
• [Presentation] Establishment of automated monitoring program for transfusional iron overload using electronic medical recording system (2013)
  • Author(s): Eisaburo, Sueoka.; Naotomo, Yamada.; Marie, Yamada.; Yasushi, Kubota.; Shinya, Kimura
  • Organizer: EUROMEDLAB Milano 2013
• [Presentation] 医療現場の隙間をうめる部門システムと電子カルテの連携‐佐賀大方式輸血後鉄過剰症モニタリングプログラムの開発‐ (2013)
  • Author(s): 末岡榮三朗、山田尚友、山田麻里江、東谷孝則、木村晋也
  • Organizer: 平成24年度大学病院情報マネージメント部門連絡会議
• [Presentation] Quenching probe法を用いたBRAF遺伝子変異検出システムの確立と本邦悪性黒色腫におけるBRAF変異の臨床的特徴 (2013)
  • Author(s): 出勝、荒金尚子、佐藤明美、木村晋也、末岡榮三朗
  • Organizer: 第17回日本がん分子標的治療学会学術集会
• [Presentation] NOJ/SCIDマウスを用いたヒト肺がん転移モデルの確立 (2013)
  • Author(s): 佐藤明美、荒金尚子、小林直美、出勝、横尾眞子、末岡榮三朗、岡田誠治、木村晋也
  • Organizer: 第17回日本がん分子標的治療学会学術集会
• [Presentation] HTLV-1ウイルス関連疾患診療ネットワーク構築のための佐賀県における総合的な取り組み (2013)
  • Author(s): 末岡榮三朗、柘植薫、福島伯泰、久保田寧、吉原麻里、蒲池和晴、北村浩晃、板村英和、吉村麻里子、進藤岳郎、安藤寿彦、出勝、横尾眞子、一戸辰夫、木村晋也
  • Organizer: 第75回日本血液学会総会
• [Presentation] Deferasirox in iron-overloaded patients with hematologic disease at Saga University Hospital (2013)
  • Author(s): Abe O, Yoshihara M, Kubota Y, Sueoak E, Kamachi K, Kitamura H, Itamura H, Nishi M, Shindo T, Fukushima N, Hamasaki Y, Kimura S
  • Organizer: 第75回日本血液学会総会
• [Presentation] 10 cases of Mogamulizumab treatment for Adult T cell Leukemia in Saga prefecture (2013)
  • Author(s): Ureshino H, Miyahara M, Kamachi K, Yoshihara M, Kitamura H, Itamura H, Yoshimura M, Yokoo M, Ide M, Kubota Y, Shindo T, Fukushima N, Sueoka E, Kimura S
  • Organizer: 第75回日本血液学会総会
• [Presentation] 低酸素応答遺伝子HIF-1αによる腫瘍原性と造血幹細胞への作用 (2013)
  • Author(s): 末岡榮三朗、出勝、荒金尚子、佐藤明美、久保田寧、木村晋也、谷本圭司
  • Organizer: がんとハイポキシア研究会
• [Presentation] Establishment of automated monitoring program for transfusional iron overload using electronic medical recording system. (2013)
  • Author(s): Eisaburo, S.; Naotomo, Y.; Marie, Y.; Yasushi, K.; Shinya, K
  • Organizer: EUROMEDLAB Milano 2013
  • Place of Presentation: Milano, Italia
• [Presentation] NOJ/SCIDマウスを用いたヒト肺がん転移モデルの確立 (2013)
  • Author(s): 佐藤 明美 、荒金 尚子 、小林 直美 、出 勝 、横尾 眞子 、末岡 榮三朗 、岡田 誠治 、木村 晋也
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 仙台市
• [Presentation] Quenching probe法を用いたBRAF遺伝子変異検出システムの確立と本邦悪性黒色腫におけるBRAF変異の臨床的特徴 (2013)
  • Author(s): 出 勝 、荒金 尚子 、佐藤 明美 、木村 晋也 、末岡 榮三朗
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 仙台市
• [Presentation] 血漿遊離核酸を用いた診断法の臨床応用の試みと問題点 (2013)
  • Author(s): 末岡榮三朗、荒金尚子、佐藤明美、中村朝美、出勝、木村晋也
  • Organizer: 第60回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸市
• [Presentation] 10 cases of Mogamulizumab treatment for Adult T cell Leukemia in Saga prefecture. (2013)
  • Author(s): Ureshino H, Miyahara M, Kamachi K, Yoshihara M, Kitamura H, Itamura H, Yoshimura M, Yokoo M, Ide M, Kubota Y, Shindo T, Fukushima N, Sueoka E, Kimura S
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: 札幌市
• [Presentation] Isthere any environmental differences to the occurrence of CRBSI in hematological patients? (2013)
  • Author(s): Kitamura H, Kubota Y, Kaneko Y, Kamachi K, Yoshihara M, Itamura H, Shindo T, Fukushima N, Ando T, Ichinohe T, Sueoka E, Aoki Y, Kimura S
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: 札幌市
• [Presentation] 自治体との連携によるＨＴＬＶ－１ウイルス関連疾患診療ネットワーク構築の試み (2013)
  • Author(s): 末岡榮三朗、柘植薫、福島伯泰、久保田寧、吉原麻里、蒲池和晴、北村浩晃、板村英和、吉村麻里子、進藤岳郎、安藤寿彦、出勝、横尾眞子、一戸辰夫、木村晋也
  • Organizer: 第6回HTLV-1研究会・シンポジウム
  • Place of Presentation: 東京
• [Presentation] 耐性原因マーカーのモニタリングによるテーラーメイド治療 (2012)
  • Author(s): 荒金尚子、中村朝美、岩永健太郎、小宮一利、末岡榮三朗、木村晋也
  • Organizer: 日本分子標的治療学会
  • Year and Date: 2012-06-27
• [Presentation] 血漿DNAを用いた非侵襲的EGFR遺伝子変異モニタリングシステムの確立 (2012)
  • Author(s): 中村朝美、荒金尚子、岩永健太郎、末岡榮三朗、木村晋也
  • Organizer: 日本分子標的治療学会
  • Year and Date: 2012-06-27
• [Presentation] 迅速診断法によるメラノーマにおけるBRAF変異の解析 (2012)
  • Author(s): 出勝、古場慎一、長野由美、荒金尚子、佐藤明美、三砂範幸、成澤寛、木村晋也、末岡榮三朗
  • Organizer: 第44回日本臨床検査自動化学会
• [Presentation] レクチンアレイを用いたATL細胞に発現するグリカンのプロファイリング (2012)
  • Author(s): 伊波英克、池辺詠美、手塚健太、藤澤順一、田中勇悦、末岡榮三朗、森下和弘、堀光雄
  • Organizer: 第71回日本癌学会総会
• [Presentation] The role of hypoxia inducible factors on maintenance of hematopoietic stem cells and leukemogenesis (2012)
  • Author(s): Eisaburo Sueoka, Masaru Ide, Naoko Sueoka-Aragane, Akemi Sato, Hideaki Nakamura, Yasushi Kubota, Shinya Kimura, Keiji Tanimoto
  • Organizer: Tumor Microenvironment Global Core Research Center Symposium Seoul, South Korea
  • Place of Presentation: Seoul, South Korea
  • Invited
• [Presentation] Taylor made treatment using monitoring biomarkers for acquired resistance to molecular targeted therapy (2012)
  • Author(s): Naoko Aragane, Akemi Sato, Kentaro Iwanaga, Naomi Kobayash, Shinya Kimura, Eisaburo Sueoka
  • Organizer: Tumor Microenvironment Global Core Research Center Symposium Seoul, South Korea
  • Place of Presentation: Seoul, South Korea
  • Invited
• [Presentation] Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma (2012)
  • Author(s): Naomi Kobayashi, Naoko Aragane, Tomomi Nakamura, Akemi Sato, Yuji Takeda, Masahiro Mitsuoka, Fumio Yamasaki, Shinichiro Hayashi, Eisaburo Sueoka, Shinya Kimura.
  • Organizer: アメリカ癌学会年会
  • Place of Presentation: Chicago
• [Presentation] DNA dependent protein kinase as a new molecular target for treatment of non-small cell lung cancer (2012)
  • Author(s): Naoko Aragane, Akemi Sato, Kentaro Iwanaga, Naomi Kobayash, Shinya Kimura, Eisaburo Sueoka.
  • Organizer: アメリカ癌学会年会
  • Place of Presentation: Chicago
• [Presentation] Mechanisms of resistance to EGFR tyrosine kinase inhibitors involving HER-family ligands and receptors (2012)
  • Author(s): Kentaro Iwanaga, Naoko Sueoka-Aragane, Akemi Sato, Tomomi Nakamura, Naomi Kobayashi, Eisaburo Sueoka, Shinya Kimura.
  • Organizer: アメリカ癌学会年会
  • Place of Presentation: Chicago
• [Presentation] Fully automated SNP detection from whole blood and mutation detection from plasma-free DNA (2012)
  • Author(s): Mariko Komori, Tomomi Nakamura, Naoko Sueoka-Aragane, et al.
  • Organizer: アメリカ癌学会年会
  • Place of Presentation: Chicago
• [Presentation] 電子カルテを利用した自己血用マイカルテによる外来の運用 (2012)
  • Author(s): 末岡 榮三朗、山田尚友、山田麻里江、久保田寧、木村晋也
  • Organizer: 日本輸血細胞治療学会
  • Place of Presentation: 郡山市
• [Presentation] 電子カルテによる輸血後鉄過剰症モニタリングプログラムの開発 (2012)
  • Author(s): 末岡栄三朗、山田尚友、山田麻里江、久保田寧、東谷孝徳、木村晋也
  • Organizer: 第44回 日本臨床検査自動化学会2012.10.12-13
  • Place of Presentation: 横浜市
• [Presentation] 悪性黒色腫におけるＢＲＡＦ変異検出のための新システムの確立 (2012)
  • Author(s): 出勝、古場慎一、長野佑美、荒金尚子、佐藤明美、井上卓也、小林直美、三砂範幸、成沢寛、木村晋也、末岡榮三朗
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] レクチンアレイを用いたＡＴＬ細胞に発現するグリカンのプロファイリング (2012)
  • Author(s): 伊波英克、池辺詠美、手塚健太、藤澤順一、田中勇悦、末岡榮三朗、森下和弘、堀光雄
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] 肺癌の新規分子標的候補であるＤＮＡ依存性キナーゼ (2012)
  • Author(s): 荒金尚子、佐藤明美、岩永健太郎、小林直美、木村晋也、末岡榮三朗
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] ＨＥＲリガンドとレセプターを標的としたＥＧＦＲチロシンキナーゼ阻害耐性化機序の解明 (2012)
  • Author(s): 岩永健太郎、荒金尚子、佐藤明美、中村朝美、小林直美、末岡榮三朗、木村晋也
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] ホジキンリンパ腫157例の治療成績〜後ろ向き多施設共同研究 (2012)
  • Author(s): *勝屋弘雄、高松泰、宮本敏浩、衛藤徹也、崔日承、大野裕樹、吉本五一、長藤宏司、末岡榮三朗、上村智彦、樋口雅一、田村和夫
  • Organizer: 第74回日本血液学会学術総会2012.10.19
  • Place of Presentation: 京都市
• [Presentation] Acute myeloid leukemia with t(3;8)(q26;q24) and monosomy 7 complicated by diabetes inspidus (2012)
  • Author(s): Yasushi Kubota，Tatsuo Ichinohe，Mariko Yoshimura，Hidekazu Itamura，Takashi Hisatomi，Noriyasu Fukushima，Eisaburo Sueoka，Miwako Matsuzaki，Masayuki Sano，Shinya Kimura
  • Organizer: 第74回日本血液学会学術総会
  • Place of Presentation: 京都市
• [Presentation] Coexistence of invasive cryptococcosis and mature B-cell neoplasm in an HIV-negative young adult (2012)
  • Author(s): Hidekazu Itamura，Takashi Hisatomi，Noriyasu Fukushima，et al.
  • Organizer: 第74回日本血液学会学術総会
  • Place of Presentation: 京都市
• [Presentation] 血漿ＤＮＡを用いた非侵襲的ＥＧＦＲ遺伝子変異モニタリングシステムの確立 (2012)
  • Author(s): 中村朝美、荒金尚子、岩永健太郎、末岡榮三朗、木村晋也
  • Organizer: 日本分子標的治療学会
  • Place of Presentation: 北九州市
• [Presentation] Quenching probe法による悪性黒色腫におけるBRAF変異の解析 (2012)
  • Author(s): 出 勝、古場慎一、長野由美、荒金尚子、佐藤明美、三砂範幸、成澤 寛、木村晋也、末岡榮三朗
  • Organizer: 第59回日本臨床検査医学会学術集会20112.11.29-12.2
  • Place of Presentation: 京都市
• [Presentation] 質量分析装置MALDIバイオタイパーでの同定精度に関する性能評価 (2012)
  • Author(s): 於保恵、永沢善三、東谷孝徳、太田昭一郎、末岡榮三朗、宮本比呂志
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都市
• [Presentation] フィブリンセルブロック作成法の検討 (2012)
  • Author(s): 久米修二、中村光男、上瀧さやか、次富久之、東谷孝徳、太田昭一郎、末岡榮三朗
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都市
• [Presentation] DNA-dependent protein kinase as a promising molecular target for the treatment of adult T-cell leukemia-lymphoma (2011)
  • Author(s): Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kunimasa A, Okamoto K, Kimura S, Sueoka E
  • Organizer: The 16th European Hematology Association Congress
• [Presentation] Gene regulation induced by constitutive expression of HIF-1αin transgenic mice (2011)
  • Author(s): Ide M, Sueoka-Aragane N, Sato A, Nakamura T, Yokoo M, Kimura S, Tanimoto K, Sueoka E
  • Organizer: AACR 102nd Annual Meeting
• [Presentation] A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA in lung cancer patients (2011)
  • Author(s): Sueoka-Aragane N, Nakamura T, Iwanaga K, Sato A, Komiya K, Abe T, Ureshino N, Hayashi S, Hosomi T, Hirai M, Sueoka E, Kimura S
  • Organizer: AACR 102nd Annual Meeting
• [Presentation] Development of New Methods for Detecting Circular Nucleic Acids as Cancer Biomarkers in Lung Cancer Patients (2011)
  • Author(s): Sueoka E, Sueoka-Aragane N, Sato A, Nakamura T, Iwanaga K and Kimura S
  • Organizer: IIFCC WorrlldLab EurroMedLab Berrlliin 2011
• [Presentation] Overexpression of hnRNP B1 inhibits DNA repair by interaction with DNA-dependent protein kinase complex in adult T-cell leukemia (2011)
  • Author(s): Sueoka E, Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kimura S
  • Organizer: 25th International Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
• [Presentation] DNA-dependent protein kinase as a promising molecular target for the treatment of adult T-cell leukemia-lymphoma. (2011)
  • Author(s): Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kunimasa A, Okamoto K, Kimura S, Sueoka E
  • Organizer: The 16th European Hematology Association Congress
  • Place of Presentation: London, UK
• [Presentation] Gene regulation induced by constitutive expression of HIF-1α in transgenic mice (2011)
  • Author(s): Ide M, Sueoka-Aragane N, Sato A, Nakamura T, Yokoo M, Kimura S, Tanimoto K, Sueoka E
  • Organizer: AACR 102nd Annual Meeting
  • Place of Presentation: Cicago, USA
• [Presentation] A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA in lung cancer patients (2011)
  • Author(s): N Sueoka-Aragane, T Nakamura, K Iwanaga, A Sato, K Komiya, T Abe, N Ureshino, S Hayashi, T Hosomi, M Hirai, E Sueoka, S Kimura
  • Organizer: AACR 102nd Annual Meeting
  • Place of Presentation: Cicago, USA
• [Presentation] Development of New Methods for Detecting Circular Nucleic Acids as Cancer Biomarkers in Lung Cancer Patients (2011)
  • Author(s): E Sueoka, N Sueoka-Aragane, A Sato, T Nakamura, K Iwanaga and S Kimura
  • Organizer: IIFCC WorrlldLab EurroMedLab Berrlliin 2011
  • Place of Presentation: Berlin, Germany
• [Presentation] Overexpression of hnRNP B1 inhibits DNA repair by interaction with DNA-dependent protein kinase complex in adult T-cell leukemia (2011)
  • Author(s): E Sueoka, T Hisatomi, N Sueoka-Aragane, A Sato, R Tomimasu, M Ide, S Kimura
  • Organizer: 25th International Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
  • Place of Presentation: Tokyo, Japan
• [Presentation] Hemostatic abnormality in patients with adult T-cell leukemia-lymphoma (2011)
  • Author(s): Kubota Y, Sano M, Kubota M, Itamura H, Urata C, Yoshimura M, Hisatomi T, Fukushima N, Sueoka E, Ichinohe T, Kimura S.
  • Organizer: 第７3回日本血液学会
  • Place of Presentation: 名古屋
• [Presentation] DNA repair as a molecular target for cancer treatment (2011)
  • Author(s): 末岡榮三朗,久富崇,荒金尚子,木村晋也
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 血漿遊離核酸を用いた肺癌の診断および治療反応性の評価 (2011)
  • Author(s): 中村朝美、末岡栄三朗、荒金尚子、木村晋也
  • Organizer: 第５８回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 電子カルテを利用した自己血用マイ・カルテによる自己血輸血情報管理 (2011)
  • Author(s): 末岡栄三朗、山田尚友、山田麻里江、久保田寧、木村晋也
  • Organizer: 第59回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜（掲載のみ）
• [Presentation] The influence of abl tyrosine kinase inhibitors on pulmonary alveolar proteinosis (2011)
  • Author(s): Yoshimura M, Itamura H, Urata C, Hisatomi T, Kubota Y, Fukushima N, Sueoka E, Ichinohe T, Kimura S.
  • Organizer: 第７3回日本血液学会
  • Place of Presentation: 名古屋
• [Book] 標本に学ぶ血液疾患症例 （溝口秀昭、齋藤英彦、吉田彌太郎、小澤敬也著） (2012)
  • Author(s): 末岡榮三朗（分担）
  • Total Pages: 427
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://www.intmed.med.saga-u.ac.jp/kenkyuugroup/group/blood-hp/index.html
• [Remarks] 佐賀大学医学部 血液・呼吸器・腫瘍内科：トップページ
  • URL: http://www.intmed.med.saga-u.ac.jp/kenkyuugroup/group/blood-hp/index.html