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The role of HIF-1a in the development of lymphoproliferative diseases in transgenic mouse model

Research Project

Project/Area Number 23591393
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionSaga University

Principal Investigator

SUEOKA Eizaburo  佐賀大学, 医学部, 教授 (00270603)

Co-Investigator(Kenkyū-buntansha) ARAGANE Naoko  佐賀大学, 医学部, 講師 (20321846)
出 勝  佐賀大学, 医学部, 助教 (00398124)
Co-Investigator(Renkei-kenkyūsha) IDE Masaru  佐賀大学, 医学部, 助教 (00398124)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords低酸素応答 / HIF-1 / リンパ腫 / 造血幹細胞 / がん幹細胞 / 薬剤耐性 / Lymphoma / hypoxia / transgenic mouse / BCR-ABL / CML / 低酸素応答遺伝子 / 幹細胞 / アポトーシス
Research Abstract

Hypoxia-inducible factor-1alfa (HIF-1 alfa) plays an important role in the induction of various genes under hypoxic condition. We investigate the role of HIF-1 alfa in tumor development and metastasis, and established transgenic mice constitutively expressing HIF-1A gene under regulation of the cytomegalovirus gene promoter. HIF-1 alfa protein levels varied among organs, but the expression of HIF-1 alfa mRNA gradually increased in an age-dependent manner. The transgenic mice developed tumors in the lymphoid, lung, and breast; the most prominent tumor was lymphoma appearing in the intestinal mucosa and intra-mesenchymal tissues. The lymphocytes of the transgenic mice revealed prolonged survival under long-term culture conditions and revealed increased resistance to cytotoxic drugs. These results suggest that HIF-1 alfa play an important role in lymphomagenesis mediated through the prolonged survival of lymphocytes in this transgenic mouse model.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (92 results)

All 2014 2013 2012 2011 Other

All Journal Article (34 results) (of which Peer Reviewed: 33 results) Presentation (55 results) (of which Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Therapeutic management in cardiac lymphoma2014

    • Author(s)
      Yoshihara M, Itamura H, Fukushima N, Itoh M, Furukawa K, Nagatomo D, Kamachi K, Kitamura H, Shindo T, Kubota Y, Sueoka E, Morita S, Ichinohe T, Kimura S
    • Journal Title

      Leuk Lymphoma

      Volume: 55 Pages: 1215-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 電子カルテと輸血管理システムの連携による輸血後鉄過剰症モニタリングプログラムの運用とその課題2014

    • Author(s)
      末岡榮三朗、山田尚友、山田麻里江、久保田寧、吉村麻里子、板村英和、出勝、横尾眞子、吉原麻里、蒲池和晴、北村浩晃、進藤岳郎、安藤寿彦、小島研介、東谷孝徳、木村晋也
    • Journal Title

      日本輸血細胞治療学会誌

      Volume: 60 Pages: 12-17

    • NAID

      130004542705

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗M(IgM+IgG)において抗体価測定時に反応増強剤無添加間接抗グロブリン試験で一部陰性を示した妊婦の1例2014

    • Author(s)
      山田麻里江、山田尚友、久保田寧、木村晋也、東谷孝徳、末岡榮三朗
    • Journal Title

      日本輸血細胞治療学会誌

      Volume: 60 Pages: 32-37

    • NAID

      130004542708

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct identification method for bacteria in positive blood culture bottles using MALDI biotyper2013

    • Author(s)
      Uki N, Oho M, Nagasawa Z, Higashitani T, Ohta S, Sueoka E, Miyamoto H
    • Journal Title

      Rinsho Byori

      Volume: 61(3) Pages: 224-30

    • NAID

      10031171348

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor promoters : from chemicals to inflammatory proteins2013

    • Author(s)
      Fujiki H, Sueoka E, Suganuma M
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 139(10) Pages: 1603-14

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival2013

    • Author(s)
      Sueoka E , Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K
    • Journal Title

      PLoS One

      Volume: 8(4)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 輸血後鉄過剰症の現状と問題点2013

    • Author(s)
      末岡榮三朗、山田尚友、山田麻里江、久保田寧、浦田千紗子、吉村麻里子、板村英和、久富崇、福島伯泰、出勝、横尾眞子、吉原麻里、蒲池和晴、北村浩晃、進藤岳郎、一戸辰夫、東谷孝徳、木村晋也
    • Journal Title

      日本輸血細胞治療学会誌

      Volume: 59 Pages: 73-78

    • NAID

      10031165492

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival.2013

    • Author(s)
      Sueoka E, Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e57833-e57833

    • DOI

      10.1371/journal.pone.0057833

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor promoters: from chemicals to inflammatory proteins.2013

    • Author(s)
      Fujiki H, Sueoka E, Suganuma M.
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 139 Issue: 10 Pages: 1603-1614

    • DOI

      10.1007/s00432-013-1455-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival.2013

    • Author(s)
      Sueoka E, Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K.
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbαto support adhesion to von Willebrand factor and collagen2012

    • Author(s)
      Takata Y, Kanaji T, Moroi M, Seki R, Sano M, Nakazato S, Sueoka E, Imamura Y, Okamura T
    • Journal Title

      Int J Hematol

      Volume: 96 Pages: 733-42

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma2012

    • Author(s)
      Katsuya H, Yamanaka T, Ishitsuka K, Utsunomiya A, Sasaki H, Hanada S, Eto T, Moriuchi Y, Saburi Y, Miyahara M, Sueoka E, Uike N, Yoshida S, Yamashita K, Tsukasaki K, Suzushima H, Ohno Y, Matsuoka H, Jo T, Suzumiya J, Tamura K
    • Journal Title

      J Clin Oncol

      Volume: 30 Pages: 1635-40

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful reduced-intensity umbilical cord blood transplant for fulminant hemophagocytic syndrome in an adult with pre-existing rheumatoid arthritis and autoimmune hemolytic anemia2012

    • Author(s)
      Itamura H, Fukushima N, Kondo S, Urata C, Tanaka-Yoshimura M, Yokoo M, Ide M, Hisatomi T, Kubota Y, Sueoka E, Ichinohe T, Kimura S
    • Journal Title

      Leuk Lymphoma

      Volume: 53 Pages: 2307-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients2012

    • Author(s)
      Tanaka A, Sueoka-Aragane N, Nakamura T, Takeda Y, Mitsuoka M, Yamasaki F, Hayashi S, Sueoka E, Kimura S
    • Journal Title

      Lung Cancer

      Volume: 75 Pages: 89-94

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful reduced-intensity umbilical cord blood transplant for fulminant hemophagocytic syndrome in an adult with pre-existing rheumatoid arthritis and autoimmune hemolytic anemia.2012

    • Author(s)
      Itamura H, Fukushima N, Kondo S, Urata C, Tanaka-Yoshimura M, Yokoo M, Ide M, Hisatomi T, Kubota Y, Sueoka E, Ichinohe T, Kimura S
    • Journal Title

      Leuk Lymphoma

      Volume: 53 Issue: 11 Pages: 2307-2309

    • DOI

      10.3109/10428194.2012.680453

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma2012

    • Author(s)
      Katsuya H, Yamanaka T, Ishitsuka K, et al.
    • Journal Title

      J Clin Oncol.

      Volume: 30 Issue: 14 Pages: 1635-1640

    • DOI

      10.1200/jco.2011.38.2101

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbα to support adhesion to von Willebrand factor and collagen2012

    • Author(s)
      Yuka Takata et al
    • Journal Title

      Int J Hematol

      Volume: 96(6) Issue: 6 Pages: 733-742

    • DOI

      10.1007/s12185-012-1216-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients.2012

    • Author(s)
      Tanaka A, Sueoka-Aragane N, Nakamura T, Takeda Y, Mitsuoka M, Yamasaki F, Hayashi S, Sueoka E, Kimura S
    • Journal Title

      Lung Cancer

      Volume: 75 Issue: 1 Pages: 89-94

    • DOI

      10.1016/j.lungcan.2011.06.004

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A noninvasive system for monitoring resistance to epidermal growth factor receptor tyrosine kinase inhibitors with plasma DNA.2012

    • Author(s)
      Nakamura T, Sueoka-Aragane N, Iwanaga K, Sato A, Komiya K, Abe T, Ureshino N, Hayashi S, Hosomi T, Hirai M, Sueoka E, Kimura S
    • Journal Title

      J Thorac Oncol 6:1639-48

      Volume: 6 Issue: 10 Pages: 1639-1648

    • DOI

      10.1097/jto.0b013e31822956e8

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA.2012

    • Author(s)
      Nakamura T, Sueoka-Aragane N, Iwanaga K, Sato A, Komiya K, Kobayashi N, Hayashi S, Hosomi T, Hirai M, Sueoka E, Kimura S
    • Journal Title

      J Thorac Oncol

      Volume: 7 Issue: 9 Pages: 1369-1381

    • DOI

      10.1097/jto.0b013e31825f2821

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influences of %T>MIC achievement probability due to the difference of the MIC measurement concentration range-analysis of meropenem for Pseudomonas aerugin2012

    • Author(s)
      Nagasawa Z, Nakashima Y, Fukutomi Y, Uki N, Kusaba K, Nagumo F, Ohta S, Sueoka E, Miyamoto H.
    • Journal Title

      Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi (Japanese).

      Volume: 22 Pages: 11-22

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 質量分析装置MALDIバイオタイパーを使用した各種ATCC株による同定精度の評価および血液培養ボトルからの直接迅速同定法の有用性に関する検討2012

    • Author(s)
      宇木望、永沢善三、草場耕二、福富由美子、末岡榮三朗、宮本比呂志
    • Journal Title

      臨床と微生物

      Volume: 39 Pages: 97-107

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type : the NK-cell Tumor Study Group (NKTSG) study2011

    • Author(s)
      Yamaguchi M, Kwong Y, Kim K, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
    • Journal Title

      J Clin Oncol

      Volume: 29 Pages: 4410-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influences of %T>MIC achievement probability due to the difference of the MIC measurement concentration range-analysis of meropenem for Pseudomonas aeruginosa2011

    • Author(s)
      Nagasawa Z, Nakashima Y, Fukutomi Y, Uki N, Kusaba K, Nagumo F, Ohta S, Sueoka E, Miyamoto H
    • Journal Title

      Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi

      Volume: 22 Pages: 11-22

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical presentation and outcome in patients of over 75 years old with malignant lymphoma2011

    • Author(s)
      Fukushima N, Itamura H, Urata C, Tanaka M, Hisatomi T, Kunota Y, Sueoka E, Kimura S
    • Journal Title

      Int J Clin Med

      Volume: 2 Pages: 246-253

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lenalidomide in combination with dexamethasone induced rhabdomyolysis in a multiple myeloma patient treated with pravastatin2011

    • Author(s)
      Urata C, Yoshimura M, Itamura H, Hisatomi T, Kubota Y, Fukushima N, Sueoka E, Kimura S
    • Journal Title

      Int J Hematol

      Volume: 94 Pages: 216-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA2011

    • Author(s)
      Nakamura T, Sueoka-Aragane N, Iwanaga K, Sato A, Komiya K, Abe T, Ureshino U, Hayashi S, Hosomi, Hirai M, Sueoka E, Kimura S
    • Journal Title

      J Thorac Oncol

      Volume: 6 Pages: 1639-48

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A fully integrated, automated and rapid detection system for KRAS mutations2011

    • Author(s)
      Ureshino N, Sueoka-Aragane N, Nakamura T, Sato A, Komiya K, Iwanaga K, Mitsuoka M, Takeda Y, Hayashi S, Sueoka E, Kimura S
    • Journal Title

      Oncol Rep

      Volume: 26 Pages: 609-13

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A fully integrated and automated detection system for single nucleotide polymorphisms of UGT1A1 and CYP2C192011

    • Author(s)
      Ureshino N, Aragane N, Nakamura T, Ide M, Mochinaga S, Fukushima N, Hayashi S, Sueoka E, Kimura S
    • Journal Title

      Oncol Res

      Volume: 19 Pages: 111-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase IIa and DNA-dependent protein kinase2011

    • Author(s)
      Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kurimasa A, Okamoto K, Kimura S, Sueoka E
    • Journal Title

      Blood

      Volume: 117 Pages: 3575-84

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cellsby inhibition of dual targets on topoisomerase II{alpha}c and DNA-dependent protein kinase.2011

    • Author(s)
      Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kurimasa A, Okamoto K, Kimura S and Sueoka E
    • Journal Title

      Blood

      Volume: 117(13) Issue: 13 Pages: 3575-84

    • DOI

      10.1182/blood-2010-02-270439

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lenalidomide in combination with dexamethasone induced rhabdomyolysis in a multiple myeloma patient treated with pravastatin.2011

    • Author(s)
      Urata C, Yoshimura M, Itamura H, Hisatomi T, Kubota Y, Fukushima N, Sueoka E, Kimura S.
    • Journal Title

      Int J Hematol

      Volume: 94 Issue: 2 Pages: 216-217

    • DOI

      10.1007/s12185-011-0903-y

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fully Integrated, Automated and Rapid Detection System for KRAS Mutations.2011

    • Author(s)
      Ureshino N, Sueoka-Aragane N, Nakamura T, Sato A, Komiya K, Iwanaga K, Mitsuoka M, Takeda Y, Hayashi S, Sueoka E, Kimura S.
    • Journal Title

      Oncol Rep

      Volume: 26 Pages: 609-613

    • DOI

      10.3892/or.2011.1341

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type : The NK-cell Tumor Study Group (NKTSG) study2011

    • Author(s)
      Yamaguchi M, et al
    • Journal Title

      Journal of Clinical Oncology

      Volume: 29(33) Issue: 33 Pages: 4410-4416

    • DOI

      10.1200/jco.2011.35.6287

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Establishment of a rapid and automated detection system for BRAF mutations in malignant melanoma2013

    • Author(s)
      Masaru Ide, Shinichi Koba, Yumi Nagano, Naoko Aragane-Sueoka, Akemi Sato, Takuya Inoue, Naomi Kobayashi, Noriyuki Misago, Yutaka Narisawa,Shinya Kimura, Eisaburo Sueoka
    • Organizer
      AACR Annual Meeting 2013
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Development of animal model mimicking metastasis of human lung cancers using NOJ/SCID mice2013

    • Author(s)
      Naoko Sueoka-Aragane, Akemi Sato, Naomi Kobayashi, Masaru Ide, Eisaburo Sueoka, Seiji Okada, Shinya Kimura
    • Organizer
      AACR Annual Meeting 2013
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Establishment of automated monitoring program for transfusional iron overload using electronic medical recording system2013

    • Author(s)
      Eisaburo, Sueoka.; Naotomo, Yamada.; Marie, Yamada.; Yasushi, Kubota.; Shinya, Kimura
    • Organizer
      EUROMEDLAB Milano 2013
    • Related Report
      2013 Final Research Report
  • [Presentation] 医療現場の隙間をうめる部門システムと電子カルテの連携‐佐賀大方式輸血後鉄過剰症モニタリングプログラムの開発‐2013

    • Author(s)
      末岡榮三朗、山田尚友、山田麻里江、東谷孝則、木村晋也
    • Organizer
      平成24年度大学病院情報マネージメント部門連絡会議
    • Related Report
      2013 Final Research Report
  • [Presentation] Quenching probe法を用いたBRAF遺伝子変異検出システムの確立と本邦悪性黒色腫におけるBRAF変異の臨床的特徴2013

    • Author(s)
      出勝、荒金尚子、佐藤明美、木村晋也、末岡榮三朗
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] NOJ/SCIDマウスを用いたヒト肺がん転移モデルの確立2013

    • Author(s)
      佐藤明美、荒金尚子、小林直美、出勝、横尾眞子、末岡榮三朗、岡田誠治、木村晋也
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] HTLV-1ウイルス関連疾患診療ネットワーク構築のための佐賀県における総合的な取り組み2013

    • Author(s)
      末岡榮三朗、柘植薫、福島伯泰、久保田寧、吉原麻里、蒲池和晴、北村浩晃、板村英和、吉村麻里子、進藤岳郎、安藤寿彦、出勝、横尾眞子、一戸辰夫、木村晋也
    • Organizer
      第75回日本血液学会総会
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Deferasirox in iron-overloaded patients with hematologic disease at Saga University Hospital2013

    • Author(s)
      Abe O, Yoshihara M, Kubota Y, Sueoak E, Kamachi K, Kitamura H, Itamura H, Nishi M, Shindo T, Fukushima N, Hamasaki Y, Kimura S
    • Organizer
      第75回日本血液学会総会
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 10 cases of Mogamulizumab treatment for Adult T cell Leukemia in Saga prefecture2013

    • Author(s)
      Ureshino H, Miyahara M, Kamachi K, Yoshihara M, Kitamura H, Itamura H, Yoshimura M, Yokoo M, Ide M, Kubota Y, Shindo T, Fukushima N, Sueoka E, Kimura S
    • Organizer
      第75回日本血液学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素応答遺伝子HIF-1αによる腫瘍原性と造血幹細胞への作用2013

    • Author(s)
      末岡榮三朗、出勝、荒金尚子、佐藤明美、久保田寧、木村晋也、谷本圭司
    • Organizer
      がんとハイポキシア研究会
    • Related Report
      2013 Final Research Report
  • [Presentation] Establishment of automated monitoring program for transfusional iron overload using electronic medical recording system.2013

    • Author(s)
      Eisaburo, S.; Naotomo, Y.; Marie, Y.; Yasushi, K.; Shinya, K
    • Organizer
      EUROMEDLAB Milano 2013
    • Place of Presentation
      Milano, Italia
    • Related Report
      2013 Annual Research Report
  • [Presentation] NOJ/SCIDマウスを用いたヒト肺がん転移モデルの確立2013

    • Author(s)
      佐藤 明美 、荒金 尚子 、小林 直美 、出 勝 、横尾 眞子 、末岡 榮三朗 、岡田 誠治 、木村 晋也
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quenching probe法を用いたBRAF遺伝子変異検出システムの確立と本邦悪性黒色腫におけるBRAF変異の臨床的特徴2013

    • Author(s)
      出 勝 、荒金 尚子 、佐藤 明美 、木村 晋也 、末岡 榮三朗
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血漿遊離核酸を用いた診断法の臨床応用の試みと問題点2013

    • Author(s)
      末岡榮三朗、荒金尚子、佐藤明美、中村朝美、出勝、木村晋也
    • Organizer
      第60回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 10 cases of Mogamulizumab treatment for Adult T cell Leukemia in Saga prefecture.2013

    • Author(s)
      Ureshino H, Miyahara M, Kamachi K, Yoshihara M, Kitamura H, Itamura H, Yoshimura M, Yokoo M, Ide M, Kubota Y, Shindo T, Fukushima N, Sueoka E, Kimura S
    • Organizer
      第75回日本血液学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Isthere any environmental differences to the occurrence of CRBSI in hematological patients?2013

    • Author(s)
      Kitamura H, Kubota Y, Kaneko Y, Kamachi K, Yoshihara M, Itamura H, Shindo T, Fukushima N, Ando T, Ichinohe T, Sueoka E, Aoki Y, Kimura S
    • Organizer
      第75回日本血液学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自治体との連携によるHTLV-1ウイルス関連疾患診療ネットワーク構築の試み2013

    • Author(s)
      末岡榮三朗、柘植薫、福島伯泰、久保田寧、吉原麻里、蒲池和晴、北村浩晃、板村英和、吉村麻里子、進藤岳郎、安藤寿彦、出勝、横尾眞子、一戸辰夫、木村晋也
    • Organizer
      第6回HTLV-1研究会・シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 耐性原因マーカーのモニタリングによるテーラーメイド治療2012

    • Author(s)
      荒金尚子、中村朝美、岩永健太郎、小宮一利、末岡榮三朗、木村晋也
    • Organizer
      日本分子標的治療学会
    • Year and Date
      2012-06-27
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 血漿DNAを用いた非侵襲的EGFR遺伝子変異モニタリングシステムの確立2012

    • Author(s)
      中村朝美、荒金尚子、岩永健太郎、末岡榮三朗、木村晋也
    • Organizer
      日本分子標的治療学会
    • Year and Date
      2012-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 迅速診断法によるメラノーマにおけるBRAF変異の解析2012

    • Author(s)
      出勝、古場慎一、長野由美、荒金尚子、佐藤明美、三砂範幸、成澤寛、木村晋也、末岡榮三朗
    • Organizer
      第44回日本臨床検査自動化学会
    • Related Report
      2013 Final Research Report
  • [Presentation] レクチンアレイを用いたATL細胞に発現するグリカンのプロファイリング2012

    • Author(s)
      伊波英克、池辺詠美、手塚健太、藤澤順一、田中勇悦、末岡榮三朗、森下和弘、堀光雄
    • Organizer
      第71回日本癌学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of hypoxia inducible factors on maintenance of hematopoietic stem cells and leukemogenesis2012

    • Author(s)
      Eisaburo Sueoka, Masaru Ide, Naoko Sueoka-Aragane, Akemi Sato, Hideaki Nakamura, Yasushi Kubota, Shinya Kimura, Keiji Tanimoto
    • Organizer
      Tumor Microenvironment Global Core Research Center Symposium Seoul, South Korea
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Taylor made treatment using monitoring biomarkers for acquired resistance to molecular targeted therapy2012

    • Author(s)
      Naoko Aragane, Akemi Sato, Kentaro Iwanaga, Naomi Kobayash, Shinya Kimura, Eisaburo Sueoka
    • Organizer
      Tumor Microenvironment Global Core Research Center Symposium Seoul, South Korea
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma2012

    • Author(s)
      Naomi Kobayashi, Naoko Aragane, Tomomi Nakamura, Akemi Sato, Yuji Takeda, Masahiro Mitsuoka, Fumio Yamasaki, Shinichiro Hayashi, Eisaburo Sueoka, Shinya Kimura.
    • Organizer
      アメリカ癌学会年会
    • Place of Presentation
      Chicago
    • Related Report
      2012 Research-status Report
  • [Presentation] DNA dependent protein kinase as a new molecular target for treatment of non-small cell lung cancer2012

    • Author(s)
      Naoko Aragane, Akemi Sato, Kentaro Iwanaga, Naomi Kobayash, Shinya Kimura, Eisaburo Sueoka.
    • Organizer
      アメリカ癌学会年会
    • Place of Presentation
      Chicago
    • Related Report
      2012 Research-status Report
  • [Presentation] Mechanisms of resistance to EGFR tyrosine kinase inhibitors involving HER-family ligands and receptors2012

    • Author(s)
      Kentaro Iwanaga, Naoko Sueoka-Aragane, Akemi Sato, Tomomi Nakamura, Naomi Kobayashi, Eisaburo Sueoka, Shinya Kimura.
    • Organizer
      アメリカ癌学会年会
    • Place of Presentation
      Chicago
    • Related Report
      2012 Research-status Report
  • [Presentation] Fully automated SNP detection from whole blood and mutation detection from plasma-free DNA2012

    • Author(s)
      Mariko Komori, Tomomi Nakamura, Naoko Sueoka-Aragane, et al.
    • Organizer
      アメリカ癌学会年会
    • Place of Presentation
      Chicago
    • Related Report
      2012 Research-status Report
  • [Presentation] 電子カルテを利用した自己血用マイカルテによる外来の運用2012

    • Author(s)
      末岡 榮三朗、山田尚友、山田麻里江、久保田寧、木村晋也
    • Organizer
      日本輸血細胞治療学会
    • Place of Presentation
      郡山市
    • Related Report
      2012 Research-status Report
  • [Presentation] 電子カルテによる輸血後鉄過剰症モニタリングプログラムの開発2012

    • Author(s)
      末岡栄三朗、山田尚友、山田麻里江、久保田寧、東谷孝徳、木村晋也
    • Organizer
      第44回 日本臨床検査自動化学会2012.10.12-13
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 悪性黒色腫におけるBRAF変異検出のための新システムの確立2012

    • Author(s)
      出勝、古場慎一、長野佑美、荒金尚子、佐藤明美、井上卓也、小林直美、三砂範幸、成沢寛、木村晋也、末岡榮三朗
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] レクチンアレイを用いたATL細胞に発現するグリカンのプロファイリング2012

    • Author(s)
      伊波英克、池辺詠美、手塚健太、藤澤順一、田中勇悦、末岡榮三朗、森下和弘、堀光雄
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺癌の新規分子標的候補であるDNA依存性キナーゼ2012

    • Author(s)
      荒金尚子、佐藤明美、岩永健太郎、小林直美、木村晋也、末岡榮三朗
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] HERリガンドとレセプターを標的としたEGFRチロシンキナーゼ阻害耐性化機序の解明2012

    • Author(s)
      岩永健太郎、荒金尚子、佐藤明美、中村朝美、小林直美、末岡榮三朗、木村晋也
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] ホジキンリンパ腫157例の治療成績〜後ろ向き多施設共同研究2012

    • Author(s)
      *勝屋弘雄、高松泰、宮本敏浩、衛藤徹也、崔日承、大野裕樹、吉本五一、長藤宏司、末岡榮三朗、上村智彦、樋口雅一、田村和夫
    • Organizer
      第74回日本血液学会学術総会2012.10.19
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] Acute myeloid leukemia with t(3;8)(q26;q24) and monosomy 7 complicated by diabetes inspidus2012

    • Author(s)
      Yasushi Kubota,Tatsuo Ichinohe,Mariko Yoshimura,Hidekazu Itamura,Takashi Hisatomi,Noriyasu Fukushima,Eisaburo Sueoka,Miwako Matsuzaki,Masayuki Sano,Shinya Kimura
    • Organizer
      第74回日本血液学会学術総会
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] Coexistence of invasive cryptococcosis and mature B-cell neoplasm in an HIV-negative young adult2012

    • Author(s)
      Hidekazu Itamura,Takashi Hisatomi,Noriyasu Fukushima,et al.
    • Organizer
      第74回日本血液学会学術総会
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] 血漿DNAを用いた非侵襲的EGFR遺伝子変異モニタリングシステムの確立2012

    • Author(s)
      中村朝美、荒金尚子、岩永健太郎、末岡榮三朗、木村晋也
    • Organizer
      日本分子標的治療学会
    • Place of Presentation
      北九州市
    • Related Report
      2012 Research-status Report
  • [Presentation] Quenching probe法による悪性黒色腫におけるBRAF変異の解析2012

    • Author(s)
      出 勝、古場慎一、長野由美、荒金尚子、佐藤明美、三砂範幸、成澤 寛、木村晋也、末岡榮三朗
    • Organizer
      第59回日本臨床検査医学会学術集会20112.11.29-12.2
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] 質量分析装置MALDIバイオタイパーでの同定精度に関する性能評価2012

    • Author(s)
      於保恵、永沢善三、東谷孝徳、太田昭一郎、末岡榮三朗、宮本比呂志
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] フィブリンセルブロック作成法の検討2012

    • Author(s)
      久米修二、中村光男、上瀧さやか、次富久之、東谷孝徳、太田昭一郎、末岡榮三朗
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] DNA-dependent protein kinase as a promising molecular target for the treatment of adult T-cell leukemia-lymphoma2011

    • Author(s)
      Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kunimasa A, Okamoto K, Kimura S, Sueoka E
    • Organizer
      The 16th European Hematology Association Congress
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene regulation induced by constitutive expression of HIF-1αin transgenic mice2011

    • Author(s)
      Ide M, Sueoka-Aragane N, Sato A, Nakamura T, Yokoo M, Kimura S, Tanimoto K, Sueoka E
    • Organizer
      AACR 102nd Annual Meeting
    • Related Report
      2013 Final Research Report
  • [Presentation] A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA in lung cancer patients2011

    • Author(s)
      Sueoka-Aragane N, Nakamura T, Iwanaga K, Sato A, Komiya K, Abe T, Ureshino N, Hayashi S, Hosomi T, Hirai M, Sueoka E, Kimura S
    • Organizer
      AACR 102nd Annual Meeting
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of New Methods for Detecting Circular Nucleic Acids as Cancer Biomarkers in Lung Cancer Patients2011

    • Author(s)
      Sueoka E, Sueoka-Aragane N, Sato A, Nakamura T, Iwanaga K and Kimura S
    • Organizer
      IIFCC WorrlldLab EurroMedLab Berrlliin 2011
    • Related Report
      2013 Final Research Report
  • [Presentation] Overexpression of hnRNP B1 inhibits DNA repair by interaction with DNA-dependent protein kinase complex in adult T-cell leukemia2011

    • Author(s)
      Sueoka E, Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kimura S
    • Organizer
      25th International Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Related Report
      2013 Final Research Report
  • [Presentation] DNA-dependent protein kinase as a promising molecular target for the treatment of adult T-cell leukemia-lymphoma.2011

    • Author(s)
      Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kunimasa A, Okamoto K, Kimura S, Sueoka E
    • Organizer
      The 16th European Hematology Association Congress
    • Place of Presentation
      London, UK
    • Related Report
      2011 Research-status Report
  • [Presentation] Gene regulation induced by constitutive expression of HIF-1α in transgenic mice2011

    • Author(s)
      Ide M, Sueoka-Aragane N, Sato A, Nakamura T, Yokoo M, Kimura S, Tanimoto K, Sueoka E
    • Organizer
      AACR 102nd Annual Meeting
    • Place of Presentation
      Cicago, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA in lung cancer patients2011

    • Author(s)
      N Sueoka-Aragane, T Nakamura, K Iwanaga, A Sato, K Komiya, T Abe, N Ureshino, S Hayashi, T Hosomi, M Hirai, E Sueoka, S Kimura
    • Organizer
      AACR 102nd Annual Meeting
    • Place of Presentation
      Cicago, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of New Methods for Detecting Circular Nucleic Acids as Cancer Biomarkers in Lung Cancer Patients2011

    • Author(s)
      E Sueoka, N Sueoka-Aragane, A Sato, T Nakamura, K Iwanaga and S Kimura
    • Organizer
      IIFCC WorrlldLab EurroMedLab Berrlliin 2011
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2011 Research-status Report
  • [Presentation] Overexpression of hnRNP B1 inhibits DNA repair by interaction with DNA-dependent protein kinase complex in adult T-cell leukemia2011

    • Author(s)
      E Sueoka, T Hisatomi, N Sueoka-Aragane, A Sato, R Tomimasu, M Ide, S Kimura
    • Organizer
      25th International Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Hemostatic abnormality in patients with adult T-cell leukemia-lymphoma2011

    • Author(s)
      Kubota Y, Sano M, Kubota M, Itamura H, Urata C, Yoshimura M, Hisatomi T, Fukushima N, Sueoka E, Ichinohe T, Kimura S.
    • Organizer
      第73回日本血液学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] DNA repair as a molecular target for cancer treatment2011

    • Author(s)
      末岡榮三朗,久富崇,荒金尚子,木村晋也
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 血漿遊離核酸を用いた肺癌の診断および治療反応性の評価2011

    • Author(s)
      中村朝美、末岡栄三朗、荒金尚子、木村晋也
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 電子カルテを利用した自己血用マイ・カルテによる自己血輸血情報管理2011

    • Author(s)
      末岡栄三朗、山田尚友、山田麻里江、久保田寧、木村晋也
    • Organizer
      第59回日本輸血・細胞治療学会総会
    • Place of Presentation
      横浜(掲載のみ)
    • Related Report
      2011 Research-status Report
  • [Presentation] The influence of abl tyrosine kinase inhibitors on pulmonary alveolar proteinosis2011

    • Author(s)
      Yoshimura M, Itamura H, Urata C, Hisatomi T, Kubota Y, Fukushima N, Sueoka E, Ichinohe T, Kimura S.
    • Organizer
      第73回日本血液学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Book] 標本に学ぶ血液疾患症例 (溝口秀昭、齋藤英彦、吉田彌太郎、小澤敬也著)2012

    • Author(s)
      末岡榮三朗(分担)
    • Total Pages
      427
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.intmed.med.saga-u.ac.jp/kenkyuugroup/group/blood-hp/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 佐賀大学医学部 血液・呼吸器・腫瘍内科:トップページ

    • URL

      http://www.intmed.med.saga-u.ac.jp/kenkyuugroup/group/blood-hp/index.html

    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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