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The role of HOXB4 in myelofibrosis and new therapy targeting USF

Research Project

Project/Area Number 23591397
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionUniversity of Miyazaki

Principal Investigator

SHIMODA KAZUYA  宮崎大学, 医学部, 教授 (90311844)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsJAK2 / TET2 / MPN / HSC / PMF / USF1/2 / JAk2
Research Abstract

We examined the gene expression patterns of Lineage-Sca1+ BM cells in JAK2V617F transgenic mice that developed myelofibrosis, and found that HOXB4 and TGF-b1, the target genes of transcriptional factor USF1, were highly expressed. The transcriptional activity of USF1 is up-regulated by thrombopoietin stimulation or JAK2 V617F via activation of MAPK.
Somatic loss-of-function mutations of TET2 are frequently observed in patients with myeloproliferative neoplasams. Mice with low TET2 exhibited only mild monocytosis, splenomegaly, and extramedullary hematopoiesis compared to wild type mice. HSCs from TET2 low mice exhibit increased self-renewal ability in vivo. In competitive transplantation assays, HSCs from TET2 low mice possess a competitive growth advantage over wild type HSCs. These data indicate that TET2 plays a critical role in HSC homeostasis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (72 results)

All 2014 2013 2012 2011

All Journal Article (29 results) (of which Peer Reviewed: 24 results) Presentation (20 results) Book (23 results)

  • [Journal Article] Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms2014

    • Author(s)
      Nakaya Y, Shide K, Naito H, Niwa T, Horio T, Miyake J, Shimoda K
    • Journal Title

      Blood Cancer J

      Volume: 4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 本邦における原発性骨髄線維症の臨床像2014

    • Author(s)
      下田和哉、竹中克斗、北中明、赤司浩一
    • Journal Title

      臨床血液

      Volume: 55(3) Pages: 289-294

    • NAID

      130004724847

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms.2014

    • Author(s)
      Nakaya Y, Shide K, Naito H, Niwa T, Horio T, Miyake J, Shimoda K.
    • Journal Title

      Blood Cancer J

      Volume: 4 Issue: 1 Pages: e174-e174

    • DOI

      10.1038/bcj.2013.73

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker+ cardiomyocytes in vivo2013

    • Author(s)
      Fukata M, Ishikawa F, Najima Y, Yamauchi T, Saito Y, Takenaka K, Miyawaki K, Shimazu H, Shimoda K, Kanemaru T, Nakamura K, Odashiro K, Nagafuji K, Harada M, Akashi K
    • Journal Title

      PLoS One

      Volume: 8(5)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent of Ezh2 and Tet2 cooperates in the Pathogenesis of myelodysplastic disorders2013

    • Author(s)
      Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A
    • Journal Title

      J.Exp.Med

      Volume: 210(12) Pages: 2627-2639

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄増殖性腫瘍の分子機構と新規薬物療法2013

    • Author(s)
      北中明、幣光太郎、下田和哉
    • Journal Title

      臨床血液

      Volume: 54(10) Pages: 151-157

    • NAID

      10031196313

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker+ cardiomyocytes in vivo.2013

    • Author(s)
      Fukata M, Ishikawa F, Najima Y, Yamauchi T, Saito Y, Takenaka K, Miyawaki K, Shimazu H, Shimoda K, Kanemaru T, Nakamura K, Odashiro K, Nagafuji K, Harada M, Akashi K
    • Journal Title

      PLoS One.

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.2013

    • Author(s)
      Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 210(12) Issue: 12 Pages: 2627-39

    • DOI

      10.1084/jem.20131144

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated HIF-1αexpression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy2012

    • Author(s)
      Matsunaga T, Imataki O, Torii E, Kameda T, Shide K, Shimoda H, Kamiunten A, Sekine M, Taniguchi Y, Yamamoto S, Hidaka T, Katayose K, Kubuki Y, Dobashi H, Bandoh S, Ohnishi H, Fukai F, Shimoda K
    • Journal Title

      Leuk Res

      Volume: 36

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute myeloid leukemia in clinical practice : a retrospective population-based cohort study in Miyazaki Prefecture, Japan2012

    • Author(s)
      Matsunaga T, Yamashita K, Kubuki Y, Toyama T, Imataki O, Maeda K, Kawano N, Satou S, Kawano H, Ishizaki J, Yoshida S, Kameda T, Sasaki T, Sekine M, Kamiunten A, Taniguchi Y, Hidaka T, Katayose K, K-Shimoda H, Shide K, Yamamoto S, Moritake H, Nunoi H, Makino S, Kitanaka A, Matsuoka H, Shimoda K
    • Journal Title

      Int J Hematol

      Volume: 96 Pages: 342-349

    • NAID

      10031121262

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation2012

    • Author(s)
      Matsunaga T, Fukai F, Kameda T, Shide K, Shimoda H, Torii E, Kamiunten A, Sekine M,Yamamoto S, Hidaka T, Kubuki Y, Yokokura S, Uemura M, Matsuoka A, Waki F, Matsumoto K, Kanaji N, Ishii T, Imataki O, Dobashi H, Bandoh S, Shimoda K
    • Journal Title

      Ann Hematol

      Volume: 91 Pages: 1633-1643

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of CADM1/TSLC1/IgSF4 expression in Adult T-cell leukemia/ ymphoma2012

    • Author(s)
      Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K
    • Journal Title

      Leukemia

      Volume: 26 Pages: 1238-1246

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TET2 is essential for survival and hematopoietic stem cell homeostasis2012

    • Author(s)
      Shide K, Kameda T, Shimoda H, Yamaji T, Abe H, Kamiunten A, Sekine M, Hidaka T, Katayose K, Kubuki Y, Yamamoto S, Miike T, Iwakiri H, Hasuike S, Nagata K, Marutsuka K, Iwama A, Matsuda T, Kitanaka A, Shimoda K
    • Journal Title

      Leukemia. Leukemia

      Volume: 26 Pages: 2216-2223

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tyk2 and stat3 regulate brown adipose tissue differentiation and obesity2012

    • Author(s)
      Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S,Hamis TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Lamer AC
    • Journal Title

      Cell Metabolism

      Volume: 16 Pages: 814-82

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TET2 is essential for survival and hematopoietic stem cell homeostasis2012

    • Author(s)
      幣光太郎
    • Journal Title

      Leukemia

      Volume: (印刷中) Issue: 10 Pages: 2216-2223

    • DOI

      10.1038/leu.2012.94

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy2012

    • Author(s)
      松永卓也
    • Journal Title

      Leukemia Research

      Volume: (印刷中) Issue: 6 Pages: 122-124

    • DOI

      10.1016/j.leukres.2012.02.028

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation2012

    • Author(s)
      Matsunaga T, Fukai F, Kameda T, Shide K, Shimoda H, Torii E, Kamiunten A, Sekine M, Yamamoto S, Shimoda K, 他12名
    • Journal Title

      Ann Hematol

      Volume: 91 Issue: 10 Pages: 1633

    • DOI

      10.1007/s00277-012-1498-y

    • URL

      https://pure.teikyo.jp/en/publications/4c94ecd9-7be9-4d48-a8fa-19bebe07a70c

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma2012

    • Author(s)
      Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K
    • Journal Title

      Leukemia

      Volume: Jan;26 (6) Issue: 6 Pages: 1238-46

    • DOI

      10.1038/leu.2011.379

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tyk2 and stat3 regulate brown adipose tissue differentiation and obesity.2012

    • Author(s)
      Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Shimoda K, 他14名
    • Journal Title

      Cell Metabolism

      Volume: 16 Issue: 6 Pages: 814-824

    • DOI

      10.1016/j.cmet.2012.11.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute myeloid leukemia in clinical practice: a retrospective population-based cohort study in Miyazaki Prefecture, Japan.2012

    • Author(s)
      Matsunaga T, Yamashita K, Kubuki Y, Toyama T, Imataki O, Maeda K, Kawano N, Satou S, Kawano H, Shimoda K, 他17名
    • Journal Title

      Int J Hematol

      Volume: 96 Issue: 3 Pages: 342-349

    • DOI

      10.1007/s12185-012-1146-2

    • NAID

      10031121262

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture2012

    • Author(s)
      河野徳明
    • Journal Title

      International Journal of Clinical Oncology

      Volume: (印刷中) Issue: 4 Pages: 336-340

    • DOI

      10.1007/s10147-011-0292-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Difference in serum complement component C4a levels between hepatitis C virus carriers with persistently normal alanine aminotransferase levels or chronic hepatitis C2012

    • Author(s)
      Imakiire K, Uto H, Sato Y, Sasaki F, Mawatari S, Ido A, Shimoda K, Hayashi K, Stuver SO, Ito Y, Okanoue T, Tsubouchi H
    • Journal Title

      Mol Med Rep

      Volume: 6(2) Pages: 259-64

    • DOI

      10.3892/mmr.2012.924

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasma2011

    • Author(s)
      Shide K, Kameda T, Markovtsov V, Shimoda HK, Tonkin E, Fang S, Liu C, Gelman M, Lang W, Romero J, McLaughlim J, Bhamidipati S, Clough J, Low C, Reitsma A, Siu S, Pine P, Park G, Tomeros A, Duan M, Singh R, Payan DG, Matsunaga T, Hitoshi Y, Shimoda K
    • Journal Title

      Blood

      Volume: 117 Pages: 6866-6875

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms2011

    • Author(s)
      Nakaya Y, Shide K, Niwa T, Homan J, Sugahara S, Horio T, Kuramoto K, Kotera T, Shibayama H, Hori K, Naito H, Shimoda K
    • Journal Title

      Blood Cancer J

      Volume: 1, (published online)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄増殖性疾患分子病態と治療2011

    • Author(s)
      下田晴子、下田和哉
    • Journal Title

      血液内科

      Volume: 62(5) Pages: 648-655

    • Related Report
      2013 Final Research Report
  • [Journal Article] 血小板増加症2011

    • Author(s)
      上運天綾子、下田和哉
    • Journal Title

      診断と治療

      Volume: 99(7) Pages: 1143-1147

    • Related Report
      2013 Final Research Report
  • [Journal Article] 骨髄増殖性腫瘍とJAK2変異2011

    • Author(s)
      関根雅明、下田和哉
    • Journal Title

      日本検査血液学雑誌

      Volume: 12(2) Pages: 224-229

    • Related Report
      2013 Final Research Report
  • [Journal Article] R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasma.2011

    • Author(s)
      Shide K
    • Journal Title

      Blood

      Volume: 117 Pages: 6866-6875

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.2011

    • Author(s)
      Peng DJ
    • Journal Title

      J Immunol.

      Volume: 186 Pages: 5638-5647

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Impact of TET2 deficiency on ^のN harboring JAK2V617F mutation2013

    • Author(s)
      Kameda T, Shide K, Sekine M, Kamiunten A,Hidaka T, Kubuki Y, Kameda T, Kitanaka A,Shimoda K, MP Marutsuka K
    • Organizer
      第55回ASH Annual Meeting and Exposition
    • Place of Presentation
      New Orleans
    • Year and Date
      2013-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Japanese survey of myelofibrosis2013

    • Author(s)
      下田和哉
    • Organizer
      第75回日本血液学会学術集会、Asian Joint Symposium
    • Place of Presentation
      札幌
    • Year and Date
      2013-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of new therapies for myelofiborosis(MF) that target the transcription factor USF12013

    • Author(s)
      Shide K, Kameda T, Shimoda H, Kamiunten A, Sekine M, Hidaka T, Kubuki Y, Kameda T, Kitanaka A,Shimoda K
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-10-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] The impact of TET2 deficiency on MPN induced by JAK2V617F mutation2013

    • Author(s)
      Kameda T, Shide K, Sekine M, Kamiunten A,Hidaka T, Kubuki Y, Kameda T, Kitanaka A,Shimoda K, Marutsuka K
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-10-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Concurrent depletion of Ezh2 and Tet2 accelerates development of myelodysplastic disorders in mice2013

    • Author(s)
      Muto T,Sashida G, Oshima M, Wendt G, Kashio MM, Nagata Y, Sanada M, Miyagi S,Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-10-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 骨髄増殖性腫瘍の分子機構と新規薬物療法2013

    • Author(s)
      下田和哉
    • Organizer
      第75回日本血液学会学術集会教育講演
    • Place of Presentation
      札幌
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Japanese survey of myelofibrosis2013

    • Author(s)
      下田和哉
    • Organizer
      第75回日本血液学会学術集会Asian Joint Symposium
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨髄増殖性腫瘍の分子機構と新規薬物療法2013

    • Author(s)
      下田和哉
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Impact of TET2 deficiency on MPN harboring JAK2V617F mutation2013

    • Author(s)
      Kameda T, Shide K, Sekine M, Kamiunten A,Hidaka T, Kubuki Y, Kameda T, Kitanaka A,Shimoda K, Marutsuka K
    • Organizer
      第55回ASH Annual Meeting and Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cooperation of JAK2V617F and CBFb-MYH11 is insufficient for leukemic transformation of mouse MPNs2012

    • Author(s)
      Kameda T, Shide K, Shimoda H, Kamiunten A, Hidaka T, Katayose K, Kubuki Y, Kitanaka A, Shimoda K, Marutsuka K
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] JAK2阻害薬によるMPNの治療2012

    • Author(s)
      幣光太郎
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] TET2 is essential for survival and hematopoietic stem cell homeostasis2012

    • Author(s)
      Shide K, Kameda T, Shimoda H, Kamiunten A, Sekine M, Hidaka T, Kubuki Y, Marutsuka K, Iwama A, Kitanaka A, Shimoda K
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] TET2 is essential for survival and hematopoietic stem cell homeostasis.2012

    • Author(s)
      Shide K, Kameda T,Shimoda H,Kamiunten A,SekineM,Hidaka T,Kubu ki Y,Marutsuka K, Iwama A, Kitanaka A, Shimoda K
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Cooperation of JAK2V617F and CBFb-MYH11 is insufficient for leukemic transformation of mouse MPNs.2012

    • Author(s)
      Kameda T,Shide K,ShimodaH, Kamiunten A, Hidaka T, Katayose K,Kubuki Y,Yoko K, Kitanaka A, Shimoda K, Marutsuka K
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] TET2 Is Essential for Survival in Mice, and Decreased TET2 Expression Enlarges HSC Compartment and Alters Cell Differentiation2011

    • Author(s)
      Shide K, Kameda T, Shimoda H, Kamiunten A, Sekine M, Hidaka T, Katayose K, Kubuki Y, Kitanaka A, Shimoda K
    • Organizer
      第American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2011-12-10
    • Related Report
      2013 Final Research Report
  • [Presentation] NS-018, a potent novel JAK2 inhibitor, effectively treats murine MPN induced by JAK2V617F mutant2011

    • Author(s)
      Shide K,Nakaya Y, Kameda T, Shimoda H, Hidaka T, Katayose K, Kubuki Y, Matsunaga T, Homan J, Kotere T, Shibayama H, Naito H, Shimoda K
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Selective and preferential inhibition of an activated form of JAK2 by a novel JAK2 inhibitor, NS-0182011

    • Author(s)
      Nakaya Y,Shide K, Niwa T, Horio T, Homan J, Sugahara S, Kuramoto K, Hori K, Naito H, Shimoda K
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical management of primary myelofibrosis patients2011

    • Author(s)
      Shimoda K
    • Organizer
      第2回日本血液学会国際シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2011-04-24
    • Related Report
      2013 Final Research Report
  • [Presentation] NS-018, a potent novel JAK2 inhibitor, effectively treats murine MPN induced by JAK2V617F mutant2011

    • Author(s)
      Shide K
    • Organizer
      第73回日本血液学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] TET2 Is Essential for Survival in Mice, and Decreased TET2 Expression Enlarges HSC Compartment and Alters Cell Differentiation2011

    • Author(s)
      Shide K
    • Organizer
      American Society of Hematology 53th Annual Meeting,
    • Place of Presentation
      San Diego CA
    • Related Report
      2011 Research-status Report
  • [Book] 骨髄増殖性腫瘍に対する分子標的治療,血液疾患最新の治療2014-2016,24-292014

    • Author(s)
      上運天綾子,下田和哉, (直江知樹,小澤敬也,中尾眞二編)
    • Publisher
      南江堂, (東京)
    • Related Report
      2013 Final Research Report
  • [Book] 骨髄線維症に対するJAK阻害薬.Annual Review血液20142014

    • Author(s)
      幣光太郎,下田和哉, (高久史麿、小澤敬也,坂田洋一,金倉譲,小島勢二編)
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] 血液疾患最新の治療2014

    • Author(s)
      上運天綾子,下田和哉
    • Total Pages
      6
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] Annual Review 血液 20142014

    • Author(s)
      幣光太郎, 下田和哉
    • Total Pages
      7
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 骨髄線維症内科学書2013

    • Author(s)
      下田和哉, (小川聡総編)
    • Publisher
      中山書店, (東京)
    • Related Report
      2013 Final Research Report
  • [Book] 慢性骨髄性白血病/骨髄増殖性腫瘍(Chronic myelogenous leukemia : CML/ myeloproliferative neoplasms : MPN)造血器腫瘍診療ガイドライン2013年版, (日本血液学会編)2013

    • Author(s)
      薄井紀子,木崎昌弘,下田和哉,高橋直人
    • Publisher
      金倉出版
    • Related Report
      2013 Final Research Report
  • [Book] 骨髄線維症,ここまできた白血病/MDS治療2013

    • Author(s)
      亀田拓郎,下田和哉, (金倉謙総編)
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] 内科学書2013

    • Author(s)
      下田和哉
    • Total Pages
      4
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] 造血器腫瘍診療ガイドライン2013年版2013

    • Author(s)
      薄井紀子,木崎昌弘,下田和哉,高橋直人
    • Total Pages
      28
    • Publisher
      金倉出版
    • Related Report
      2013 Annual Research Report
  • [Book] 治療2013

    • Author(s)
      亀田拓郎,下田和哉
    • Total Pages
      6
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] 真性赤血球増加症,本態性血小板血症,原発性骨髄線維症.今日の治療指針2012年版私はこう治療している2012

    • Author(s)
      下田和哉, (山口徹,北原光夫,福井次夫編)
    • Publisher
      金原出版社
    • Related Report
      2013 Final Research Report
  • [Book] 骨髄線維症に対する新規治療薬.Annual Review血液20122012

    • Author(s)
      北中明,下田和哉, (高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編)
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] MPNに対する分子標的療法の可能性. EBM血液疾患の治療2012

    • Author(s)
      亀田拓郎,下田和哉, (金倉譲,木崎昌弘,鈴木律朗,神田善伸)
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] 慢性骨髄性白血病・骨髄増殖性腫瘍.新臨床腫瘍学(改訂第3版)がん薬物療法専門医のために.日本臨床腫瘍学会編2012

    • Author(s)
      下田和哉
    • Publisher
      (株)南江堂
    • Related Report
      2013 Final Research Report
  • [Book] 骨髄系骨髄増殖性腫瘍のモデル動物を用いた解析. Annual Review血液20132012

    • Author(s)
      幣光太郎,下田和哉, (高久史麿,小澤敬也,坂田洋一,金倉譲,小島勢二編)
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] Annual Review 血液20122012

    • Author(s)
      北中明、下田和哉
    • Total Pages
      266
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] 今日の治療指針2021年版私はこうして治療している2012

    • Author(s)
      下田和哉
    • Total Pages
      2064
    • Publisher
      金原出版社
    • Related Report
      2012 Research-status Report
  • [Book] 原発性骨髄線維症,血液専門医テキスト,日本血液学会編(ア)2011

    • Author(s)
      幣光太郎,下田和哉
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] 原発性骨髄線維症,専門医のための薬物療法Q&A血液,編2011

    • Author(s)
      谷口康博,下田和哉
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] 骨髄線維症,難治性貧血診療ガイド-特発性造血障害の病態・診断・治療の最新動向,難治性貧血診療ガイド2011

    • Author(s)
      竹中克斗,下田和哉,赤司浩一, (編集委員会編集)
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] 原発性骨髄線維症の診断と治療,白血病・リンパ腫・骨髄腫-今日の診断と治療2011

    • Author(s)
      北中明,下田和哉, (木崎昌弘編)
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] 白血病・リンパ腫・骨髄腫-今日の診断と治療2011

    • Author(s)
      北中明
    • Total Pages
      544
    • Publisher
      中外医学社
    • Related Report
      2011 Research-status Report
  • [Book] Annual Review 血液 20122011

    • Author(s)
      北中明
    • Total Pages
      266
    • Publisher
      中外医学社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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