Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Research Abstract |
Global levels of the long interspersed nuclear element-1 (LINE-1) methylation declined with the degree of malignancy of plasma cells, and there was a significant inverse correlation between the degree of genomic loss and the LINE-1 methylation levels. Finally, there was a significant association between LINE-1 hypomethylation and poorer overall survival. Our findings suggest that global hypomethylation of LINE-1 may increase the malignant potential of myeloma cells by inducing broad copy-number losses.
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