Development of the new myeloma treatment based on the comprehensive analysis for genome structure abnormality and epigenome abnormality
| Project/Area Number |
23591399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
ISHIDA Tadao 札幌医科大学, 医学部, 准教授 (20305220)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hiroshi 札幌医科大学, 道民医療推進学講座, 助教 (60570132)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | multiple myeloma / methylation / LINE-1 / multiple mueloma / myeloma / 多発性骨髄腫 / 長鎖散在反復配列 / メチル化 |
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| Research Abstract |
Global levels of the long interspersed nuclear element-1 (LINE-1) methylation declined with the degree of malignancy of plasma cells, and there was a significant inverse correlation between the degree of genomic loss and the LINE-1 methylation levels. Finally, there was a significant association between LINE-1 hypomethylation and poorer overall survival. Our findings suggest that global hypomethylation of LINE-1 may increase the malignant potential of myeloma cells by inducing broad copy-number losses.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma.2012
Author(s)
Aoki Y, Nojima M, Suzuki H, Yasui H, Maruyama R, Yamamoto E, Ashida M, ItagakiM, Asaoku H, Ikeda H, Hayashi T, Imai K, Mori M, Tokino T, Ishida T, Toyota M, Shinomura Y.
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Journal Title
Genome Med.
Volume: 4
Pages: 101-114
Related Report
Peer Reviewed
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[Journal Article] Epidemiology and treatment outcome of invasive fungal infections in patients with hematologicalmalignancies2012
Author(s)
Kurosawa M, Yonezumi M, Hashino S, Tanaka J, Nishio M, Kaneda M, Ota S, Koda K, Suzuki N, Yoshida M, Hirayama Y, Takimoto R, Torimoto Y,Mori A, Takahashi T, Iizuka S, Ishida T, Kobayashi R, Oda T, Sakai H, Yamamoto S, Takahashi F, Fukuhara T
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Journal Title
Int J Hematol
Volume: 96(6)
Issue: 6
Pages: 748-57
DOI
Related Report
Peer Reviewed
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[Journal Article] Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo.2011
Author(s)
Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T,Tsujisaki M, Shinomura Y, Imai K.
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Journal Title
PLoS One
Volume: 6
Pages: 1-9
Related Report
Peer Reviewed
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[Journal Article] Efficacy of Long-Term Treatment with Low-Dose Thalidomide for Patients with Relapsed/Refractory Multiple Myeloma.2011
Author(s)
Shimizu K, Murakami H, Sawamura M, Hattori Y, Okamoto S, Miwa A,Sugiura I, Shimazaki C,Taniwaki M,Ishida T, KosugiH,Yuge M,Iida S, Ishida T,Sunami K,Asaoku H,Sakai A,Abe M,Takagi T.
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Journal Title
International Journal of Clinical Medicine
Volume: 2
Pages: 570-575
Related Report
Peer Reviewed
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[Journal Article] In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody.2011
Author(s)
Watanabe Y, Asano R, Arai K, Shimomura I, Ogata H, Kawaguchi H, Hayashi H, Ohtsuka H, Yoshida H, Katayose Y, Egawa S, Nakanishi T, Umetsu M, Ishida T, Imai K, Kudo T, Unno M, Kumagai I.
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Journal Title
Oncol Rep.
Volume: 26
Pages: 949-955
Related Report
Peer Reviewed
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[Presentation] Hypomethylation of Retrotransposons is Correlated with Malignant Levels, Frequency of Chromosomal Aberrations, and Poor Prognosis in Multiple Myeloma.2012
Author(s)
Yasui H, Aoki Y, Nojima M, Suzuki H, Maruyama Y, Maruyama R, Yamamoto E, Itagaki M, Ikeda H, Hayashi T, Asaoku H, Imai K, Ishida T, Shinomura Y.
Organizer
JSH International Symposium 2012 in Kawagoe
Place of Presentation
Kawagoe, Japan
Related Report
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[Presentation] Hypomethylation of endogenous retrotransposons is correlated with frequent chromosomal deletions and poor prognosis in multiple myeloma.2012
Author(s)
Yasui H, Aoki Y, Nojima M, Suzuki H, Maruyama Y, Maruyama R, Yamamoto E, Itagaki M, Ikeda H, Hayashi T, Asaoku H, Imai K, Ishida T, Shinomura Y.
Organizer
17th Congress of the European Hematology Association
Place of Presentation
Amsterdam, Netherlands
Related Report
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[Presentation] 多発性骨髄腫の発生におけるDNAメチロームの意義：MBDシーケンシング法によるアプローチ2012
Author(s)
Nojima M, Aoki Y, Yasui H, Maruyama R, Asaoku H, Ishida T, Tokino T, Mori M, Suzuki H, Shinomura Y.
Organizer
第71回日本癌学会学術総会
Place of Presentation
Sapporo, Japan
Related Report
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[Presentation] The significance of global hypomethylation of DNA repetitive elements in multiple myeloma2012
Author(s)
Aoki Y, Nojima M, Yasui H, Suzuki H, Maruyama R, Ikeda H, Hayashi T, Ishida T, Asaoku H, Shinomura Y.
Organizer
第74回日本血液学会学術集会
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] GENOMIC SCREENING FOR GENES SILENCED BY DNA METHYLATION TO EXPLORE EPIGENETIC BIOMARKERS FOR PREDICTION OF SENSITIVITY TO DEXAMETHASONE IN MULTIPLE MYELOMA2011
Author(s)
ISHIDA T, YASUI H, NOJIMA M, AOKI Y, ITAGAKI M, MARUYAMA R, IKEDA H, SUZUKI H, SAKAI H, HAYASHI T, ASAOKU H, IMAI K, TOYOTA M, SHINOMURA Y
Organizer
IMW
Place of Presentation
Paris
Related Report
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[Presentation] Methylome analysis using next-generation sequencing in multiple myeloma2011
Author(s)
Hiroshi Yasui, Masanori Nojima, Yuka Aoki,Shintaro Takatsuka, Reo Maruyama, Hiromu Suzuki, Toshiaki Hayashi, Hideki Asaoku, Kohzoh Imai,Minoru Toyota, Tadao Ishida, Yasuhisa Shinomura
Organizer
日本血液学会
Place of Presentation
名古屋
Related Report
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