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Analysis of myeloma stem cells and their niche

Research Project

Project/Area Number 23591404
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionKyoto Pharmaceutical University (2012-2013)
Kyoto Prefectural University of Medicine (2011)

Principal Investigator

ASHIHARA Eishi  京都薬科大学, 薬学部, 教授 (70275197)

Co-Investigator(Kenkyū-buntansha) HIRAI Hideyo  京都大学, 大学院医学研究科, 助教 (50315933)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords多発性骨髄腫 / 低酸素 / 骨髄微小環境 / がん幹細胞 / 低酸素環境 / TGF-β / がん微小環境
Research Abstract

We investigated the characteristics of hypoxia-adapted MM (HA-MM) cells. Irradiated NOD/SCID mice were inoculated with AMO-1 MM cells. After 2 or 4 weeks transplantation, the inoculated MM cells were positive for pimonidazole. These observations suggested that MM cells are hypoxic in the BM. We then established HA-MM cell lines that can continue to proliferate in hypoxic conditions (1% O2) for more than six months. The G0 fraction cells significantly increased in HA-MM cells compared with those in the parental MM cells. The survival durations of mice transplanted with HA-MM cells were significantly shorter than that of mice transplanted with parental MM cells. Stem cell markers such as Sox2, Oct3, and Nanog mRNA transcripts increased in the HA-MM AMO-1 cells. Furthermore, phosphorylated Smad2 expression was increased in HA-AMO-1 cells. These findings suggest that HA-MM cells possess stem cell-like characters and may provide a useful model to investigate the mechanism of MM stem cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (88 results)

All 2013 2012 2011 Other

All Journal Article (29 results) (of which Peer Reviewed: 28 results,  Open Access: 1 results) Presentation (47 results) Book (8 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis.2013

    • Author(s)
      1. Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y.
    • Journal Title

      J Immunol

      Volume: 191 Issue: 3 Pages: 1073-1081

    • DOI

      10.4049/jimmunol.1203535

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative comparison of protein dynamics in live cells and in vitro by in-cell (19)F-NMR.2013

    • Author(s)
      Takaoka Y, Kioi Y, Morito A, Otani J, Arita K, Ashihara E, Ariyoshi M, Tochio H, Shirakawa M, Hamachi I.
    • Journal Title

      Chem Commun

      Volume: 49 Issue: 27 Pages: 2801-2803

    • DOI

      10.1039/c3cc39205h

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β.2013

    • Author(s)
      Hirai H
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: e54862-e54862

    • DOI

      10.1371/journal.pone.0054862

    • NAID

      120005242481

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion.2013

    • Author(s)
      5. Hayashi Y, Hirai H, Kamio N, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T.
    • Journal Title

      Leukemia

      Volume: 27 Issue: 3 Pages: 619-628

    • DOI

      10.1038/leu.2012.258

    • NAID

      120005466670

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells2013

    • Author(s)
      Y. Sawai, H. Murata, M. Horii, K. Koto,T. Matsui, N. Horie, Y. Tsuji, E. Ashihara, T. Maekawa, T. Kubo, S. Fushiki
    • Journal Title

      Oncol Rep

      Volume: 29 Issue: 3 Pages: 941-945

    • DOI

      10.3892/or.2012.2195

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Zoledronic acid significantly enhances radiation induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.2013

    • Author(s)
      8. Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S.
    • Journal Title

      Int J Oncol

      Volume: 42 Issue: 2 Pages: 525-534

    • DOI

      10.3892/ijo.2012.1735

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice2013

    • Author(s)
      Inden M, Takata K, Nishimura K, Kitamura Y, Ashihara E, Yoshimoto K, Ariga H, Honmou O, Shimohama S
    • Journal Title

      Journal of Neuroscience Research

      Volume: 91 Issue: 1 Pages: 62-72

    • DOI

      10.1002/jnr.23128

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 非小細胞性肺がん患者に対する簡易懸濁法を用いたエルロチニブ投与に関する検討.2013

    • Author(s)
      高田哲也、池見泰明、福土将秀、杉本充弘、石橋直哉、小林政彦、矢野育子、金永学、三嶋理晃、芦原英司、松原和夫.
    • Journal Title

      医療薬学

      Volume: 39 Pages: 565-570

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An inhibitor of Na+/H+ exchanger (NHE), ethyl-isopropyl amiloride (EIPA), diminished proliferation of MNK28 human gastric cancer cells by decreasing the cytosolic Cl- concentration via DIDS-sensitive pathways.2012

    • Author(s)
      Hosogi S
    • Journal Title

      Cell Physiol Biochem

      Volume: 30 Issue: 5 Pages: 1241-1253

    • DOI

      10.1159/000343315

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] C/EBP is involved in the amplification of early granulocyte precursors during candidemia-induced ‘emergency’ granulopoiesis.2012

    • Author(s)
      Satake S
    • Journal Title

      J Immunol

      Volume: 198 Issue: 9 Pages: 4546-4555

    • DOI

      10.4049/jimmunol.1103007

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of low-intensity pulsed ultrasound (LIPUS) on osteosarcoma and cancer cells.2012

    • Author(s)
      Sawai Y
    • Journal Title

      Oncol Rep

      Volume: 28 Issue: 2 Pages: 481-486

    • DOI

      10.3892/or.2012.1816

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ranslational Research of Photodynamic Therapy with Acridine Orange which Targets Cancer Acidity.2012

    • Author(s)
      Kusuzaki K
    • Journal Title

      Curr Pharm Des

      Volume: 18 Pages: 1414-1420

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] AV-65, a novel Wnt/βcatenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model2011

    • Author(s)
      Yao H, Ashihara E, Yokota A, Shimazaki C. (他13名)
    • Journal Title

      Blood Cancer J

      Volume: 1 Issue: 6 Pages: 903-909

    • DOI

      10.1038/bjc.2011.41

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeting the Wnt/β-catenin signaling pathway in human cancers2011

    • Author(s)
      Yao H, Ashihara E, Maekawa T
    • Journal Title

      Expert Opinion on Therapeutic Targets

      Volume: 15 Issue: 7 Pages: 873-887

    • DOI

      10.1517/14728222.2011.577418

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-3(Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia2011

    • Author(s)
      Yamamoto-Sugitani M, Kuroda J, Ashihara E, Nagoshi H, Kobayashi T, Matsumoto Y, Sasaki N, Shimura Y, Kiyota M, Nakayama R, Akaji K, Taki T, Uoshima N, Kobayashi Y, Horiike S, Maekawa T, Taniwaki M
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Issue: 42 Pages: 17468-17473

    • DOI

      10.1073/pnas.1111138108

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients2011

    • Author(s)
      Tanaka, R., Kimura, S., Ashihara, E., Yoshimura, M., Takahashi, N., Wakita, H., Itoh, K., Nishiwaki, K., Suzuki, K., Nagao, R., Yao, H., Hayashi, Y., Satake, S., Hirai, H., Sawada, K-I., Ottmann, O. G., Melo, J. V.
    • Journal Title

      Cancer Letter

      Volume: 312(2) Issue: 2 Pages: 228-34

    • DOI

      10.1016/j.canlet.2011.08.009

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition of imatinib-resistant CML cells with the T315 mutation and hypoxia-adaptation by AV65 。Va novel Wnt/υ-catenin signaling inhibitor2011

    • Author(s)
      Nagao, R., Ashihara, E., Kimura, S., Strovel, J. W., Yao, H., Takeuchi, M., Tanaka, R., Hayashi, Y., Hirai, H., Padia, J., Strand, K.
    • Journal Title

      Cancer Letter

      Volume: 312(1) Issue: 1 Pages: 91-100

    • DOI

      10.1016/j.canlet.2011.08.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined effects of novel heat shock protein 90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen2011

    • Author(s)
      Tauchi T, Okabe S, Ashihara E. (他3名)
    • Journal Title

      Oncogene

      Volume: 30 Issue: 24 Pages: 2789-2797

    • DOI

      10.1038/onc.2011.3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells2011

    • Author(s)
      Takeuchi M, Ashihara E, Maekawa T, et al
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 3 Pages: 591-6

    • DOI

      10.1111/j.1349-7006.2010.01813.x

    • NAID

      10029291246

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis2011

    • Author(s)
      Sakai K, Ashihara E, Maekawa T, et al
    • Journal Title

      Eur J Immunol

      Volume: 41 Issue: 1 Pages: 67-75

    • DOI

      10.1002/eji.200939931

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting the Wnt/beta-catenin signaling pathway in human cancers.2011

    • Author(s)
      Yao H, Ashihara E, Maekawa T.
    • Journal Title

      Expert Opinion on Therapeutic Targets

      Volume: 15 Pages: 873-87

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Galectin-3 induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia.2011

    • Author(s)
      Yamamoto-Sugitani M, Kuroda J, Ashihara E,et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Pages: 17468-73

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients.2011

    • Author(s)
      Tanaka R, Ashihara E, Maekawa T, et al.
    • Journal Title

      Cancer Lett

      Volume: 312 Pages: 228-34

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65, a novel Wnt/beta-catenin signaling inhibitor.2011

    • Author(s)
      Nagao R, Ashihara E, Maekawa T, et al.
    • Journal Title

      Cancer Lett

      Volume: 312 Pages: 91-100

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells.2011

    • Author(s)
      Takeuchi M, Ashihara E, Maekawa T,et al.
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 591-6

    • NAID

      10029291246

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis..2011

    • Author(s)
      Sakai K, Ashihara E, Maekawa T,et al.
    • Journal Title

      Eur J Immunol

      Volume: 39 Pages: 67-75

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] RNA Interference against Polo-like kinase-1 in advanced non-small cell lung cancers.2011

    • Author(s)
      Kawata E, Ashihara E, Maekawa T.
    • Journal Title

      J Clin Bioinformatics

      Volume: 1 Pages: 6-6

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] アンチセンス研究入門46 RNA干渉のがん治療への応用.2011

    • Author(s)
      芦原英司
    • Journal Title

      Antisense

      Volume: 15 Pages: 31-47

    • Related Report
      2011 Research-status Report
  • [Journal Article] Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells

    • Author(s)
      Yao H, Miura Y, Ashihara E, Hirai H, et al. (他11名)
    • Journal Title

      Stem Cells

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Hypoxia-adapted myeloma cells possess stem cell-like character2013

    • Author(s)
      Ashihara E, Hirai H, et al
    • Organizer
      The 55^<th> Annual Meeting of American Society of Hematology
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Direct interaction with bone marrow mesenvhymal stromal/stem cells is required for hematopoietic expansion by parathyroid hormone2013

    • Author(s)
      Yao H, Miura Y, Ashihara E, et al
    • Organizer
      The 55^<th> Annual Meeting of American Society of Hematology
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of C/EBPβis involved in the exhaustion of hematopoietic stem cells through cell-intrinsic and cell-extrinsic mechanisms2013

    • Author(s)
      Tamura A, Hirai H, Ashihara E, et al
    • Organizer
      The 55^<th> Annual Meeting of American Society of Hematology
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Cytokine-STATs signaling upregulate C/EBPβin BCR-ABL+ leukemic cells independently from BCR-ABL/JAK-STAT pathway2013

    • Author(s)
      Yokota A, Hirai H, Ashihara E, et al
    • Organizer
      The 55^<th> Annual Meeting of American Society of Hematology
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Microglia-like monocytic cells derived from bone marrow cells phagocytose amyloid-βand facilitate phagocytosis of amyloid-βby resident microglia2013

    • Author(s)
      Takata K, Ashihara E, et al
    • Organizer
      The 55^<th> Annual Meeting of American Society of Hematology
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Myeloid-derived suppressor cells have regulatory roles in mouse collagen-induced arthritis2013

    • Author(s)
      Fujii W, Ashihara E, Kawahito Y, et al
    • Organizer
      The Annual European Congress of Rheumatology
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Hypoxia-adapted myeloma cells possess stem cell-like character.2013

    • Author(s)
      1. Ashihara E, Nakagawa Y, Yao H, Yokota A, Miura Y, Takata K, Kitamura Y, Hirai H, Maekawa T.
    • Organizer
      The 55th Annual Meeting of American Society of Hematology.
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Direct interaction with bone marrow mesenchymal stromal/stem cells is required for hematopoietic expansion by parathyroid hormone.2013

    • Author(s)
      2. Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Tamura A, Yokota A, Ashihara E, Ichinohe T, Hirai H, Maekawa T.
    • Organizer
      The 55th Annual Meeting of American Society of Hematology.
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression of C/EBPβ is involved in the exhaustion of hematopoietic stem cells through cell-intrinsic and cell-extrinsic mechanisms.2013

    • Author(s)
      3. Tamura A, Hirai H, Hayashi Y, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T.
    • Organizer
      The 55th Annual Meeting of American Society of Hematology.
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cytokine-STATs signalings upregulate C/EBPβ in BCR-ABL+ leukemic cells independently from BCR-ABL/JAK-STAT pathway.2013

    • Author(s)
      4. Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T.
    • Organizer
      The 55th Annual Meeting of American Society of Hematology.
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Microglia-like monocytic cells derived from bone marrow cells phagocytose amyloid-β and facilitate phagocytosis of amyloid-β by resident microglia.2013

    • Author(s)
      5. Takata K, Toji Y, Kawanishi S, Takada T, Kitamura Y, Ashihara E.
    • Organizer
      The 55th Annual Meeting of American Society of Hematology.
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Myeloid-Derived Suppressor Cells have regulatory roles in mouse collagen-induced arthritis.2013

    • Author(s)
      6. Fuji W, Ashihara E, Hirai H, Nagahara H, Fujioka K, Murakami K, Nakamura K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y.
    • Organizer
      The Annual European Congress of Rheumatology.
    • Place of Presentation
      Madrid, Spain.
    • Related Report
      2013 Annual Research Report
  • [Presentation] M-CSF刺激による造血幹細胞からのアミロイドβ貪食細胞への分化誘導.2013

    • Author(s)
      高田和幸、河西翔平、杜氏裕美子、北村佳久、芦原英司
    • Organizer
      第75回日本血液学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Glioblastoma-derived exosomes targeting to cancer cells and their lipid characterization.2013

    • Author(s)
      Toda Y,Takata K, Kobayashi K, Hattori Y,Akaji K, Ashihara E.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] C/EBPβis upregulated through STAT5 and accelerates exhaustion of leukemic stem cells during BCR-ABL-mediated myeloid expansion2012

    • Author(s)
      Hayashi H, Hirai H, Ashihara E, et al
    • Organizer
      The 54^<th> Annual Meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] C/EBPβ-mediated expansion of hematopoietic stem/progenitors precedes'Emergency'granulopoiesis induced by cadidemia2012

    • Author(s)
      Tamura A, Hirai H, Ashihara E, et al
    • Organizer
      The 54^<th> Annual Meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Myeloid-derived suppressor cells accumulated in spleens of mice with collagen-induced arthritis and inhibited immune response of CD4+ T cells2012

    • Author(s)
      Fujii W, Ashihara E, Kawahito Y, et al
    • Organizer
      The 2012 American College of Rheumatology Annual meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] AV-65, a novel Wnt/β-catenin signal inhibitor, suppresses progression of multiple myeloma in a mouse model2012

    • Author(s)
      Ashihara E et al
    • Organizer
      The 3dr JSH International Symposium
    • Place of Presentation
      Kawagoe, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規Wnt/β-カテニン経路阻害剤AV65による多発性骨髄腫細胞の増殖抑制効果2012

    • Author(s)
      芦原英司、他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] C/EBPβ Is Upregulated Through STAT5 and Accelerates Exhaustion of Leukemic Stem Cells During BCR-ABL-Mediated Myeloid Expansion.2012

    • Author(s)
      Hayashi H
    • Organizer
      The 54th American Society of Hematology Annual Meeting and Exposition.
    • Place of Presentation
      Atlanta, USA.
    • Related Report
      2012 Research-status Report
  • [Presentation] C/EBPβ-Mediated Expansion of Hematopoietic Stem/Progenitors Precedes ‘Emergency’ Granulopoiesis Induced by Candidemia.2012

    • Author(s)
      Tamura A
    • Organizer
      The 54th American Society of Hematology Annual Meeting and Exposition.
    • Place of Presentation
      Atlanta, USA.
    • Related Report
      2012 Research-status Report
  • [Presentation] M-CSFを処置した骨髄由来造血幹細胞によるアミロイドβの貪食.2012

    • Author(s)
      杜氏 裕美子
    • Organizer
      第6回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Myeloid-Derived Suppressor Cells Accumulated in Spleens of Mice with Collagen-Induced Arthritis and Inhibited Immune Response of CD4+ T cells.2012

    • Author(s)
      Fuji W
    • Organizer
      The 2012 American College of Rheumatology Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Parathyroid hormone stimulates mesenchymal stem cells to enhance expansion of hematopoietic cells.2012

    • Author(s)
      Yao H
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of C/EBPβ in the pathogenesis of chronic phase chronic myeloid leukemia.2012

    • Author(s)
      Hayashi Y
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] BCR/ABLによるC/EBPbetaの発現亢進が慢性骨髄性白血病の骨髄球系造血亢進および病態進行をもたらす.2012

    • Author(s)
      林 嘉宏
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規Wnt/β-カテニン経路阻害剤AV65による多発性骨髄腫細胞の増殖抑制効果.2012

    • Author(s)
      芦原英司
    • Organizer
      .第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 原発性胆汁性肝硬変患者が保有するHLA抗体の特異性について.2012

    • Author(s)
      万木紀美子
    • Organizer
      第21回日本組織適合性学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞外HMGB1によるミクログリアのアミロイドβ1-40の貪食阻害作用.2012

    • Author(s)
      高田哲也
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Monocytes derived from bone marrow cells by macrophage colony-stimulating factor treatment effectively phagocytose amyloid-β.2012

    • Author(s)
      Kazuyuki Takata
    • Organizer
      SEH-Society for Hematology and Stem Cells-41st Annual Scientific Meeting
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Research-status Report
  • [Presentation] BCR/ABLの白血病原性における転写因子C/EBPβの関与.2012

    • Author(s)
      林 嘉宏
    • Organizer
      第16回日本がん分子標的治療学会
    • Place of Presentation
      北九州
    • Related Report
      2012 Research-status Report
  • [Presentation] AV-65, a Novel Wnt/&#61538;-catenin Signal Inhibitor, Suppresses Progression of Multiple Myeloma in a Mouse Model.2012

    • Author(s)
      Ashihara E.
    • Organizer
      The 3rd JSH International Symposium.
    • Place of Presentation
      Kawagoe, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] AV-65 inhibited the growth of myeloma cells by enhancingβ-TrCP-mediatedβ-catenin ubiquitination2011

    • Author(s)
      Yao H, Ashihara E, et al
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Future prospect of RNA interference for cancer therapies2011

    • Author(s)
      Ashihara E
    • Organizer
      The12^<th> Congress of the Asian Society of Transplantation
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] BCR/ABL-mediated myeloid expresion is promoted by C/EBPβ, a regulator of emergency granulopoiesis2011

    • Author(s)
      Hayashi Y, Hirai H, Ashihara E, et al
    • Organizer
      The 53^<rd> Annual Meeting of American Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Targeting the hedgehog signaling pathway in therapy-resistant Bcr-Abl1 positive leukemia with ponatinib2011

    • Author(s)
      Tauchi T, Ashihara E, et al
    • Organizer
      The 53^<rd> Annual Meeting of American Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] A microfluidic device to mimic the bone marrow environment : real-time observation of the leukemic cell behavior2011

    • Author(s)
      Munaka T, Ashihara E, et al
    • Organizer
      The 15^<th> International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] BCR/ABL-mediated myeloid expresion is promoted by C/EBP beta, a regulator of emergency granulopoiesis.2011

    • Author(s)
      Hayashi Y, Hirai H, Ashihara E, et al.
    • Organizer
      第53回アメリカ血液学会
    • Place of Presentation
      米国、サンディエゴ
    • Related Report
      2011 Research-status Report
  • [Presentation] Combined effects of a pan-Abl1 kinase inhibitor, ponatinib and dasatinib against T315I mutant forms of Bcr-Abl1: in vitro and in vivo studies2011

    • Author(s)
      Tauchi T, Ashihara E, Ohyashiki K, et al.
    • Organizer
      第53回アメリカ血液学会
    • Place of Presentation
      米国、サンディエゴ
    • Related Report
      2011 Research-status Report
  • [Presentation] Targeting the hedgehog signaling pathway in therapy-resistant Bcr-Abl1 positive leukemia with ponatinib.2011

    • Author(s)
      Katagiri S, Ashihara E, Ohyashiki K, et al.
    • Organizer
      第53回アメリカ血液学会
    • Place of Presentation
      米国、サンディエゴ
    • Related Report
      2011 Research-status Report
  • [Presentation] A microfluidic device to mimic the bone marrow environment: real-time observation of the leukemic cell behavior.2011

    • Author(s)
      Munaka T, Ashihara E, Maekawa T, et al.
    • Organizer
      The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences.
    • Place of Presentation
      米国、シアトル
    • Related Report
      2011 Research-status Report
  • [Presentation] Future prospect of RNA interference for cancer therapies.2011

    • Author(s)
      Ashihara E.
    • Organizer
      The12th Congress of the Asian Society of Transplantation(招待講演)
    • Place of Presentation
      韓国、ソウル
    • Related Report
      2011 Research-status Report
  • [Presentation] Galectin-3 induced by leukemia microenvironment promotes drug resistance and BM lodgment in CML.2011

    • Author(s)
      Yamamoto M、Kuroda J, Ashjhara E, et al.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Combined effects of the hedgehog inhibitor LDE225 and nilotinib in a random mutagesesis screen.2011

    • Author(s)
      Tauchi T, Ashihara E, Ohyasiki K, et al.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Involvement of C/EBPβ in BCR/ABL-dependent leukemogenesis.2011

    • Author(s)
      Hayashi Y, Hirai H, Ashihara E, et al.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] AV-65 inhibited the growth of myeloma cells by enhancing β-TrCP-mediated β-catenin ubiquitination.2011

    • Author(s)
      Yao H, Ashihara E, et al.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] がん細胞指向性を有するヒト星状膠芽腫細胞由来エキソソームの発見.

    • Author(s)
      戸田侑紀、高田和幸、中川由布子、小林数也、服部恭尚、北村佳久、赤路健一、芦原英司.
    • Organizer
      第5回日本RNAi研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Book] Nmerging Trends in Cell and Gene Therapy2013

    • Author(s)
      Ashihara E, Maekawa T
    • Total Pages
      705
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] 多発性骨髄腫Updating.第4巻移植適応骨髄腫の治療.新規薬剤時代における移植適応患者の治療戦略2013

    • Author(s)
      芦原英司
    • Total Pages
      203
    • Publisher
      医療ジャーナル社
    • Related Report
      2013 Final Research Report
  • [Book] 多発性骨髄腫 Updating.第4巻 移植適応骨髄腫の治療.~新規薬剤時代における移植適応患者の治療戦略~2013

    • Author(s)
      芦原英司.
    • Total Pages
      203
    • Publisher
      医療ジャーナル社
    • Related Report
      2013 Annual Research Report
  • [Book] RNA Interference for Oncology: Clinical Prospects Beyond the Hype. In: Emerging Trends in Cell and Gene Therapy.2013

    • Author(s)
      Ashihara E, Maekawa T.
    • Total Pages
      705
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] Development of Cell Therapeutic Strategies for Alzheimer’s Disease Using Animal Models. Animal Models in Human Disease2013

    • Author(s)
      Takata K
    • Publisher
      Nova Science Publishers
    • Related Report
      2012 Research-status Report
  • [Book] New concept of limb salvage surgery in musculoskeletal sarcoma with acridine orange therapy.2012

    • Author(s)
      Kusuzaki K
    • Total Pages
      14
    • Publisher
      Nova Science Publishers
    • Related Report
      2012 Research-status Report
  • [Book] RAN医学・医療―新たな診断・治療を拓く―2011

    • Author(s)
      芦原英司、前川平
    • Total Pages
      608
    • Publisher
      医歯薬出版
    • Related Report
      2013 Final Research Report
  • [Book] RAN医学・医療―新たな診断・治療を拓く―2011

    • Author(s)
      芦原英司、前川 平
    • Total Pages
      608
    • Publisher
      医歯薬出版
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://labo.kyoto-phu.ac.jp/seiri/seiri-j.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 京都薬科大学・生命薬科学系 病態生理学分野

    • URL

      http://www.kyoto-phu.ac.jp/labo/seiri/seiri-j.html

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] マイクロ反応装置を用いた細胞運動評価システム2012

    • Inventor(s)
      務中達也、阿部浩久、叶井正樹、前 川 平、木村晋也、芦 原英司、庄子習一
    • Industrial Property Rights Holder
      株式会社島津製作所 国立大学法人 京都大学 学校法人早稲田大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-12-28
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞選別器及び細胞選別方法2011

    • Inventor(s)
      務中達也、阿部浩久、叶井正樹、前 川 平、木村晋也、芦原英司
    • Industrial Property Rights Holder
      株式会社島津製作所 国立大学法人 京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-210160
    • Filing Date
      2011-09-27
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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