Analysis of leukemic microenvironment in RUNX1/EVI1 mouse model
| Project/Area Number |
23591406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
NAKAMURA Yuka 獨協医科大学, 医学部, 講師 (80364595)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 白血病モデルマウス / 白血病幹細胞 / 骨髄微小環境 / ニッチ因子 |
|---|
| Research Abstract |
Mice transplanted with RUNX1/EVI1-expressed bone marrow cells showed increased number of platelets and splenomegaly. In these mice increased number of megakaryocyte was recognized in bone marrow and spleen. RUNX1/EVI1 enhanced colony replating activity of hematopoietic cells. The expression level of Skp2, which is one of a target genes of RUNX1/EVI1, was decreased in colony forming cells gradually. Some mice developed leukemia after transplantation. c-Kit-positive leukemic cells invaded bone marrow, spleen and liver.
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Report
(4 results)
Research Products
(5 results)
