| Project/Area Number |
23591412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Akita University |
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Principal Investigator |
SAWADA Kenichi 秋田大学, 医学(系)研究科(研究院), 教授 (90226069)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所 先端分子医学研究部門, 教授 (50233200)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 造血幹・前駆細胞 / CD34+細胞 / 樹状細胞 / TLR / IL-10 / 二本鎖RNA / 一本鎖DNA / アポトーシス / マウスモデル / 血球貪食症候群 / ウイルス感染 / I型インターフェロン / CCR2 / 免疫制御 / 腫瘍壊死因子 / 阻害剤 / 造血幹細胞移植 / 移植片対宿主病 / CpG-ODN / 二重鎖RNA / ヒト造血幹細胞 / TLR3 / poly I:C / ROG-I / MDA5 |
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| Research Abstract |
Dendritic cells (DC) produce various cytokines which may regulate the differentiation of hematopoietic stem cells (HSCs), however, the details of the relationship between dendritic cells and HSCs remains unclear. In this project, I revealed that the DC-stimulator TLR3 induces the prompt death of HSCs in vitro. Using mouse model, I also demonstrated that TLR9 stimulation or viral infection induces hemophagocytic syndrome, and that the phagocytes are monocyte-derived dendritic cells that produce IL-10. The produced IL-10 down-regulated hemophagocytosis, which suggests that hemophagocytosis is a novel immune suppressive mechanism to suppress an excessive immune response.
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