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Control of hematopoiesis by dendritic cells

Research Project

Project/Area Number 23591412
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionAkita University

Principal Investigator

SAWADA Kenichi  秋田大学, 医学(系)研究科(研究院), 教授 (90226069)

Co-Investigator(Renkei-kenkyūsha) OHTEKI Toshiaki  東京医科歯科大学, 難治疾患研究所 先端分子医学研究部門, 教授 (50233200)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords造血幹・前駆細胞 / CD34+細胞 / 樹状細胞 / TLR / IL-10 / 二本鎖RNA / 一本鎖DNA / アポトーシス / マウスモデル / 血球貪食症候群 / ウイルス感染 / I型インターフェロン / CCR2 / 免疫制御 / 腫瘍壊死因子 / 阻害剤 / 造血幹細胞移植 / 移植片対宿主病 / CpG-ODN / 二重鎖RNA / ヒト造血幹細胞 / TLR3 / poly I:C / ROG-I / MDA5
Research Abstract

Dendritic cells (DC) produce various cytokines which may regulate the differentiation of hematopoietic stem cells (HSCs), however, the details of the relationship between dendritic cells and HSCs remains unclear. In this project, I revealed that the DC-stimulator TLR3 induces the prompt death of HSCs in vitro. Using mouse model, I also demonstrated that TLR9 stimulation or viral infection induces hemophagocytic syndrome, and that the phagocytes are monocyte-derived dendritic cells that produce IL-10. The produced IL-10 down-regulated hemophagocytosis, which suggests that hemophagocytosis is a novel immune suppressive mechanism to suppress an excessive immune response.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma2014

    • Author(s)
      Ito M, Teshima K, Ikeda S, Kitadate A, Watanabe A, Nara M, Yamashita J, Ohshima K, Sawada K, Tagawa H
    • Journal Title

      Blood

      Volume: 123(10) Pages: 1499-511

    • Related Report
      2013 Final Research Report
  • [Journal Article] Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses2013

    • Author(s)
      Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Müller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, Ohteki T
    • Journal Title

      Immunity

      Volume: 39(3) Pages: 584-98

    • NAID

      40020181881

    • Related Report
      2013 Final Research Report
  • [Journal Article] Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus.2013

    • Author(s)
      Takahashi N, Imanishi K, Uchiyama T
    • Journal Title

      Microbiol Immunol

      Volume: 57 Issue: 3 Pages: 737-745

    • DOI

      10.1016/j.immuni.2013.06.019

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A synthetic double-stranded RNA, poly I : C, induces a rapid apoptosis of human CD34(+) cells2012

    • Author(s)
      Liu J, Guo YM, Hirokawa M, Iwamoto K, Ubukawa K, Michishita Y, Fujishima N, Tagawa H, Takahashi N, Xiao W, Yamashita J, Ohteki T, Sawada K
    • Journal Title

      Exp Hematol

      Volume: 40(4) Pages: 330-41

    • Related Report
      2013 Final Research Report
  • [Journal Article] Enucleation of human erythroblasts involves non-muscle myosin IIB2012

    • Author(s)
      Ubukawa K, Guo YM, Takahashi M, Hirokawa M, Michishita Y, Nara M, Tagawa H, Takahashi N, Komatsuda A, Nunomura W, Takakuwa Y, Sawada K
    • Journal Title

      Blood

      Volume: 119(4) Pages: 1036-44

    • Related Report
      2013 Final Research Report
  • [Journal Article] A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34+ cells2012

    • Author(s)
      Liu J
    • Journal Title

      Experimental Hematology

      Volume: 40(4) Issue: 4 Pages: 330-341

    • DOI

      10.1016/j.exphem.2011.12.002

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Enucleation of human erythroblasts is an actomyosin- dependent process following nuclear polarization2011

    • Author(s)
      Ubukawa K, Yong-Mei Guo, Hirokawa M, Michishita Y, Nara M, Tagawa H, Takahashi N , Komatsuda A , Nunomura W, Takakuwa Y, Sawada K
    • Organizer
      16th Congress of European Hematology Association
    • Place of Presentation
      London
    • Related Report
      2013 Final Research Report
  • [Presentation] RIG-I and MDA-5 signaling triggers apoptosis of human CD34+ cells in type 1 IFNs independent pathway2011

    • Author(s)
      Jiajia Liu, Y M Guo, Hirokawa M, Iwamoto K, Yamashita J, Ubukawa K, Michishita Y, Fujishima N, Tagawa H, Takahashi N, Ohteki T, Sawada K
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.imcr.gunma-u.ac.jp/gcoe/jpn/organization/members/sawada/index.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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