Development of antigen-specific T cell immunotherapy using iPS cells of antigen-specific T cell origin
Project/Area Number |
23591413
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Kyoto University (2012-2013) The University of Tokyo (2011) |
Principal Investigator |
KANEKO Shin 京都大学, iPS細胞研究所, 准教授 (40361331)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 抗原特異的T細胞 / iPS細胞 / T細胞分化 / 免疫再生治療 / T細胞治療 / 免疫再生 / リプログラミング |
Research Abstract |
Antigen-specific T cells play a central role for protecting a host against various type of pathogen including neoplastic tumor and viral infections. There are many cell therapeutic approaches using ex vivo expanded immune cells including antigen-specific T cells of cancer or chronic viral infection patients, however, expansion related T-cell senescence causes severe decrease of therapeutic efficacy. To overcome the problem, we have focused on iPS cells as source of antigen specific T cells and successfully we have developed a method to obtain rejuvenated CD8 single positive T cells preserving antigen-specificity of original T cells by using of plurypotent reprogramming technology. Such rejuvenated CD8 T cells were revealed to have enough function as cytotoxic T cells (Nishimura T et al., Cell Stem Cell 12;114-126, 2013).
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate Megakaryopoiesis and Erythropoiesis.2013
Author(s)
Shinji Hirata, Naoya Takayama,Ryoko Jono-Ohnishi, Hiroshi Endo, Sou Nakamura, Takeaki Dohda, Masanori Nishi, Yuhei Hamazaki, Ei-ichi Ishii, Shin Kaneko, Makoto Otsu, Hiromitsu Nakauchi, Shinji Kunishima, and Koji Eto.
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Journal Title
J Clin Invest.
Volume: 123
Issue: 9
Pages: 3802-14
DOI
Related Report
Peer Reviewed
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[Journal Article] IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.2011
Author(s)
Bondanza A, Hambach L, Aghai Z, Nijmeijer B, Kaneko S, Mastaglio S, Radrizzani M, Fleischhauer K, Ciceri F, Bordignon C, Bonini C, Goulmy E.
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Journal Title
Blood
Volume: 117
Pages: 6469-6478
Related Report
Peer Reviewed
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[Presentation] The entities and molecular pathogenesis of Primary Myelofibrosis.2011
Author(s)
Takafumi Shimizu, Shin Kaneko, Akihiko Ito, Shoichi Iriguchi, Keiichi Ito, Satoshi Yamazaki, Toshinobu Nishimura, Toshio Kitamura, Atsushi Miyajima, and Hiromitsu Nakauchi,
Organizer
73rd annual meeting of Japanese Society of Hematology
Place of Presentation
名古屋
Related Report
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