The development of a novel monitoring method for early diagnosis of bronchiolitis obliterans after allo-HSCT

• Project/Area Number: 23591417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Okayama University
• Principal Investigator: FUJII NOBUHARU 岡山大学, 大学病院, 講師 (60362977)
• Co-Investigator(Kenkyū-buntansha): TANIMOTO Yasushi 南岡山医療センター, 臨床研究部・臨床研究, 部長 (60284098)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 閉塞性細気管支炎 / 特発性肺炎症候群 / 同種造血細胞移植

Research Abstract

Bronchiolitis obliterans syndrome is a devastating complication of allogeneic hematopoietic cell transplantation. A novel method for early diagnosis before it reaches an irreversible stage is required. We performed cytokine/chemokine analysis using serum, bronchoalveolar lavage fluid, and exhaled breath condensate of our patients. As a result, serum MIP-1 alpha, MIP-1 beta, TNF-alpha were selected as candidates of possible biomarkers for early diagnosis.

Research Products

• [Journal Article] Mammalian target of rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease (2014)
  • Author(s): Sugiyama H, Maeda Y, Nishimori H, Yamasuji Y, Matsuoka K, Fujii N, Kondo E, Shinagawa K, Tanaka T, Takeuchi K, Teshima T, Tanimoto M
  • Journal Title: Biol Blood Marrow Transplant Volume: 20(2) Pages: 183-91
  • NAID: 120005469526
  • Peer Reviewed
• [Journal Article] Bronchiolitis obliterans with allogeneic hematopoietic cell transplantation : a 10-year experience of the Okayama BMT Group (2014)
  • Author(s): Fujii N, Nakase K, Asakura S, Matsuo K, Nawa Y, Sunami K, Nishimori H, Matsuoka K, Kondo E, Maeda Y, Shinagawa K, Hara M, Tanimoto M
  • Journal Title: Int J Hematol Volume: 99(5) Pages: 644-51
  • Peer Reviewed
• [Journal Article] Complete resolution of steroid-resistant organizing pneumonia associated with myelodysplastic syndrome following allogeneic hematopoietic cell transplantation (2014)
  • Author(s): Asano T, Fujii N, Niiya D, Nishimori H, Fujii K, Matsuoka K-I, Ichimura K, Hamada T, Kondo E, Maeda Y, Tanimoto Y, Shinagawa K, Tanimoto M
  • Journal Title: SpringerPlus Volume: 3 Issue: 1 Pages: 3-3
  • DOI: 10.1186/2193-1801-3-3
  • ISSN: 2193-1801
  • Peer Reviewed
• [Journal Article] Bronchiolitis obliterans with allogeneic hematopoietic cell transplantation: a 10-year experience of the Okayama BMT Group. (2014)
  • Author(s): Fujii N, Nakase K, Asakura S, Matsuo K, Nawa Y, Sunami K, Nishimori H, Matsuoka KI, Kondo E, Maeda Y, Shinagawa K, Hara M, Tanimoto M.
  • Journal Title: Int J Hematol Volume: Epub ahead of prin
  • Peer Reviewed
• [Journal Article] 同種造血幹細胞移植後の肺合併症 ～閉塞性細気管支炎の病態と治療の現状～ (2014)
  • Author(s): 藤井伸治、品川克至
  • Journal Title: 臨床血液 Volume: Epub ahead of prin
  • NAID: 130004678956
  • Peer Reviewed
• [Presentation] A case of Non-infectious pulmonary complication after DLI. Pulmonary GVHD or IPS? (2013)
  • Author(s): 藤井伸治
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2013-10-11
• [Presentation] ドナーリンパ球輸注後の非感染性肺合併症を来たした1例 (2013)
  • Author(s): 藤井伸治、西江美由紀、三村雄輔、浅野豪、三村由香、青江伯規、中島宏美、青江啓介、松岡賢市、近藤英生、前田嘉信、品川克至、谷本光音
  • Organizer: 第75回日本血液学会
  • Place of Presentation: ロイトン札幌
• [Presentation] 同種造血細胞移植後の閉塞性細気管支炎-岡山BMTグループ3施設での経験-; Bronchiolitis Obliterans Syndrome after allogeneic hematopoietic stem cell transplantation
  • Author(s): 藤井 伸治、 松岡 賢市、 近藤 英生、前田 嘉信、品川 克至、池田 和眞、谷本 光音、池田 和眞、中瀬 浩一、名和 由一郎、原 雅道、朝倉 昇司、角南 一貴、 原 嘉孝
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 愛知県名古屋市