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Development of monitoring systems for CMVpp65 specific CTLs restricted to each HLA class I.

Research Project

Project/Area Number 23591418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionOkayama University

Principal Investigator

KONDO Eisei  岡山大学, 医歯(薬)学総合研究科, 講師 (30379747)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsCTL / CMV pp65 / HSCT / CMV / サイトメガロウイルス / 同種造血幹細胞移植
Research Abstract

CMV pp65 specific T cells are able to be detected in magnetically separated CD8+ T cells by IFNg ELISPOT assay with epitope peptide pulsed CD40-activated B cells, but not with peptide alone or unseparated PBMCs. Under written informed consent, PBMCs were collected and stored from five CMV sero-positive HLA identical donors and their recipients. After identification of unknown CMV pp65 epitopes, IFNg ELISPOT assay with the epitope peptides will be conducted.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2013 2012

All Journal Article (1 results) Presentation (3 results)

  • [Journal Article] 抗PD-1抗体2013

    • Author(s)
      近藤英生,木浦勝行
    • Journal Title

      呼吸

      Volume: 32(12) Pages: 1141-1147

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] MTX中止直後に一過性の白血球増多を認め,その後自然退縮したMTX‐LPDの一例2013

    • Author(s)
      近藤英生,葛島清隆,市村浩一,前田嘉信,藤井伸治,松岡賢市,品川克至,長谷川詠子,黒井大雅,佐伯恭昌,浅野豪,高田尚良,佐藤康晴,吉野正,谷本光音
    • Organizer
      日本リンパ網内系学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] MTX中止直後に一過性の白血球増多を認め, その後自然退縮したMTX-LPDの一例2013

    • Author(s)
      近藤英生, 葛島清隆, 市村浩一, 前田嘉信, 藤井伸治, 松岡賢市, 品川克至, 長谷川詠子, 黒井大雅, 佐伯恭昌, 浅野豪, 高田尚良, 佐藤康晴, 吉野正, 谷本光音
    • Organizer
      日本リンパ網内系学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 同種移植後のサイトメガロウイルス抗原血症が急性骨髄性白血病の再発に及ぼす影響2012

    • Author(s)
      吉田将平、近藤英生、浅野豪、廻勇輔、吉岡尚徳、西之原正昭、藤原英晃、岡本幸代、淺田騰、西森久和、藤井敬子、松岡賢市、藤井伸治、前田嘉信、品川克至、谷本光音
    • Organizer
      第34回日本造血細胞移植学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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