Development of a novel comprehensive therapy targeting aurora kinase-A for adult T cell leukemia
| Project/Area Number |
23591419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Ehime University |
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Principal Investigator |
AZUMA Taichi 愛媛大学, 医学部附属病院, 講師 (10396252)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUKAWA Masaki 愛媛大学, 大学院医学系研究科, 教授 (60127917)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 造血器腫瘍 / 細胞免疫療法 / 細胞傷害性T細胞 |
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| Research Abstract |
In this study, aiming at a development of novel adoptive immunotherapy against adult T-cell leukemia (ATL) which is one of the most treatment-refractory T-lymphoid malignancy, we newly demonstrated the clinical feasibility of adoptive immunotherapy targeting human telomerase reverse transcriptase (hTERT) for the treatment of ATL, and also demonstrated the potential advantage of Aurora kinase-A (AURKA) as a novel therapeutic target for ATL. In addition, we started to extend our therapeutic strategy against ATL from that based on T-cell receptor gene-modified T-cell to newly designed chimeric receptor gene-modified T cell-based one.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia2013
Author(s)
Miyazaki Y, Fujiwara H, Asai H, Ochi F, Ochi T, Azuma T, Ishida T, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M
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Journal Title
Blood
Volume: 121(24)
Pages: 4894-901
Related Report
Peer Reviewed
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[Presentation] Co-Administration of Gene-Modified CD4+ T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia.
Author(s)
Hiroshi Fujiwara, Fumihiro Ochi, Toshiki Ochi, Sachiko Okamoto, Hiroaki Asai,Yukihiro Miyazaki, Taichi Azuma, Junichi Mineno, Miwako Narita, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa
Organizer
55th American Society of Hematology, Annual meeting and Exposition
Place of Presentation
New Orleans, LA, USA
Related Report
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[Presentation] Human telomerase reverse transcriptase-specific T-cell receptor gene transfer redirects T cells to display an effective antitumor reactivity against adult T-cell leukemia.
Author(s)
Hiroshi Fujiwara, Yukihiro Miyazaki, Fumihiro Ochi, Hiroaki Asai, Taichi Azuma, Takashi Ishida, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa.
Organizer
39th Annual Meeting of the European Group for Blood and Marrow Transplantation
Place of Presentation
London, UK
Related Report
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