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Development of a novel comprehensive therapy targeting aurora kinase-A for adult T cell leukemia

Research Project

Project/Area Number 23591419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionEhime University

Principal Investigator

AZUMA Taichi  愛媛大学, 医学部附属病院, 講師 (10396252)

Co-Investigator(Renkei-kenkyūsha) YASUKAWA Masaki  愛媛大学, 大学院医学系研究科, 教授 (60127917)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords造血器腫瘍 / 細胞免疫療法 / 細胞傷害性T細胞
Research Abstract

In this study, aiming at a development of novel adoptive immunotherapy against adult T-cell leukemia (ATL) which is one of the most treatment-refractory T-lymphoid malignancy, we newly demonstrated the clinical feasibility of adoptive immunotherapy targeting human telomerase reverse transcriptase (hTERT) for the treatment of ATL, and also demonstrated the potential advantage of Aurora kinase-A (AURKA) as a novel therapeutic target for ATL. In addition, we started to extend our therapeutic strategy against ATL from that based on T-cell receptor gene-modified T-cell to newly designed chimeric receptor gene-modified T cell-based one.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (13 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Analysis of chemotherapy-induced neutropenia and optimal timing for prophylactic use of G-CSF in B-cell non-Hodgkin lymphoma patients treated with R-CHOP2014

    • Author(s)
      Shikata H, Yakushijin Y, Yamanouchi J, Azuma T, Yasukawa M
    • Journal Title

      Int J Clin Oncol

      Volume: 19(1) Pages: 178-85

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia2013

    • Author(s)
      Miyazaki Y, Fujiwara H, Asai H, Ochi F, Ochi T, Azuma T, Ishida T, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M
    • Journal Title

      Blood

      Volume: 121(24) Pages: 4894-901

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.2013

    • Author(s)
      Yasukawa M, et al.
    • Journal Title

      Blood

      Volume: 121 Issue: 24 Pages: 4894-4901

    • DOI

      10.1182/blood-2012-11-465971

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel redirected T cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.2013

    • Author(s)
      Miyazaki Y et al.
    • Journal Title

      Blood

      Volume: 未

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of chemotherapy-induced neutropenia and optimal timing for prophylactic use of G-CSF in B-cell non-Hodgkin lymphoma patients treated with R-CHOP.2013

    • Author(s)
      Shikata H et al.
    • Journal Title

      Int J Clin Oncol.

      Volume: 未 Issue: 1 Pages: 178-185

    • DOI

      10.1007/s10147-013-0523-z

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of activation-induced cytidine deaminase in the progression of follicular lymphoma2012

    • Author(s)
      Shikata H, Yakushijin Y, Matsushita N, Sakai A, Sugita A, Nakamura N, Yamanouchi J, Azuma T, Hato T,Yasukawa M
    • Journal Title

      Cancer Sci

      Volume: 103(3) Pages: 415-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aurora kinase A-specific T-cell receptor gene transfer redirects T-lymphocytes to display effective anti-leukemia reactivity2012

    • Author(s)
      Kozo Nagai, et al
    • Journal Title

      Blood

      Volume: 119(2) Issue: 2 Pages: 368-76

    • DOI

      10.1182/blood-2011-06-360354

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Requisite considerations for successful adoptive immunotherapy with engineered T-lymphocytes using tumor antigen-specific T-cell receptor gene transfer.2011

    • Author(s)
      Ochi T, et al
    • Journal Title

      Expert Opin Biol Ther.

      Volume: 11(6) Pages: 699-713

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Co-Administration of Gene-Modified CD4^+ T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia2013

    • Author(s)
      Fujiwara H, Azuma T, Yasukawa M, et al
    • Organizer
      55^<th> American Society of Hematology, Annual meeting and Exposition
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2013-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Human telomerase reverse transcriptase‒specific T-cell receptor gene transfer redirects T cells to display an effective antitumor reactivity against adult T-cell leukemia2013

    • Author(s)
      Fujiwara H, Azuma T, Yasukawa M, et al
    • Organizer
      39^<th> Annual Meeting of the European Group for Blood and Marrow Transplantation
    • Place of Presentation
      London, UK
    • Year and Date
      2013-04-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人T細胞白血病に対するhTERT特異的TCR遺伝子を用いた新たな細胞免疫療法の開発.2012

    • Author(s)
      宮崎 幸大 他
    • Organizer
      第34回日本造血細胞移植学会総会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Research-status Report
  • [Presentation] Human telomerase reverse transcriptase-specific T-cell receptor gene transfer redirects T-lymphocytes to exert effective antitumor reactivity against adult T-cell leukemia.2011

    • Author(s)
      Yukihiro Miyazaki, et al
    • Organizer
      The 53th Annual meeting of American Society of Hematology
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of a novel gene-immunotherapy for adult T-cell leukemia using hTERT-siTCR gene transfer.2011

    • Author(s)
      Yukihiro Miyazaki, et al
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] Co-Administration of Gene-Modified CD4+ T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia.

    • Author(s)
      Hiroshi Fujiwara, Fumihiro Ochi, Toshiki Ochi, Sachiko Okamoto, Hiroaki Asai,Yukihiro Miyazaki, Taichi Azuma, Junichi Mineno, Miwako Narita, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa
    • Organizer
      55th American Society of Hematology, Annual meeting and Exposition
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human telomerase reverse transcriptase-specific T-cell receptor gene transfer redirects T cells to display an effective antitumor reactivity against adult T-cell leukemia.

    • Author(s)
      Hiroshi Fujiwara, Yukihiro Miyazaki, Fumihiro Ochi, Hiroaki Asai, Taichi Azuma, Takashi Ishida, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa.
    • Organizer
      39th Annual Meeting of the European Group for Blood and Marrow Transplantation
    • Place of Presentation
      London, UK
    • Related Report
      2013 Annual Research Report
  • [Presentation] Preclinical evaluation for renal safety of WT1-targeting adoptive immunotherapy.

    • Author(s)
      Hiroaki Asai et al.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] キメラ型CD16遺伝子改変T細胞は抗腫瘍性ADCC活性におけるNK細胞の問題点を解決できる可能性がある。

    • Author(s)
      藤原 弘 他.
    • Organizer
      第36回日本造血細胞移植学会
    • Place of Presentation
      宜野湾市
    • Related Report
      2013 Annual Research Report
  • [Presentation] HLA class I拘束性腫瘍抗原特異的TCRを遺伝子導入したCD4陽性T細胞の機能解析。

    • Author(s)
      宮崎幸大 他.
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 成人T細胞白血病に対するhTERT特異的TCR遺伝子を用いた新たな細胞免疫療法の開発。

    • Author(s)
      宮崎幸大 他.
    • Organizer
      第4回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] Redirected T-cell based immunotherapy targeting hTERT displays an anti-tumor reactivity against adult T cell leukemia.

    • Author(s)
      Hirofumi Ochi et al.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] hTERT-specific TCR gene transduced T cells display an effective anti-tumor reactivity against ATL.

    • Author(s)
      Yukihiro Miyazaki et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Book] 「多発性骨髄腫」高齢者総合診療ノート2014

    • Author(s)
      東太地、安川正貴
    • Publisher
      日本医事新報社
    • Related Report
      2013 Final Research Report
  • [Book] 「組織球・樹状細胞の異常と血球貪食症候群」カラーテキスト血液病学(第2版)2012

    • Author(s)
      東太地、安川正貴
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/school/int.med1/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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