Human herpesvirus-6 encephalitis after allogeneic stem cell transplantation: analysis of pathologic condition to predict the development.
Project/Area Number |
23591422
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Oita University |
Principal Investigator |
OGATA Masao 大分大学, 医学部, 講師 (10332892)
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Co-Investigator(Kenkyū-buntansha) |
SATOU Takako 大分大学, 医学部, 研究補佐員 (90420645)
KOHNO Kazuhiro 大分大学, 医学部, 助教 (80420644)
KADOTA Jun-ichi 大分大学, 医学部, 教授 (50233838)
TAKANO Kuniko 大分大学, 医学部, 特任助教 (20617427)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 造血細胞移植 / ヒトヘルペス6 / ヒトヘルペス6脳炎 / サイトカイン / HHV-6 / HHV-6脳炎 / interleukin-6 / interleukineー6 |
Research Abstract |
To elucidate the immunological pathogenesis of human herpesvirus (HHV)-6 encephalitis, we performed detailed cytokine study against 172 HCT recipients, including 20 patients with HHV-6 encephalitis. Seventeen kinds of cytokines in plasma samples collected weekly until 28 days after HCT, and cerebrospinal fluid (CSF) at the time of developing HHV-6 encephalitis were measured. The plasma IL-8, -10, -13, MCP-1, and MIP-1b were significantly higher in patients who developed HHV-6 encephalitis than those without HHV-6 encephalitis. High-level IL-6 predicted poor prognosis for patients with HHV-6 encephalitis. Among patients with HHV-6 encephalitis, IL-5, -6, and -8 in CSF were higher in patients who progress to severe status (died of encephalitis or sequelae) than in other patients. We suggest that several cytokines mediate the pathogenesis of HHV-6 encephalitis. Increased levels of cytokines in plasma and CSF predict development and poor prognosis of HHV-6 encephalitis.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation : a multicenter, prospective study2013
Author(s)
Ogata M, Satou T, Kadota J, Saito N, Yoshida T, Okumura H, Ueki T, Nagafuji K, Kako S, Uoshima N, Tsudo M, Itamura H, Fukuda T
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Journal Title
Clin Infect Dis
Volume: 57
Pages: 671-681
Related Report
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[Journal Article] Foscarnet against human herpesvirus (HHV) -6 reactivation after allo-SCT : breakthrough HHV-6 encephalitis following antiviral prophylaxis2013
Author(s)
Ogata M, Satou T, Inoue Y, Takano K, Ikebe T, Ando T, Ikewaki J, Kohno K, Nishida A, Saburi M, Miyazaki Y, Ohtsuka E, Saburi Y, Fukuda T, Kadota J
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Journal Title
Bone Marrow Transplant
Volume: 48
Pages: 257-264
Related Report
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[Journal Article] Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study2013
Author(s)
Ogata M, Satou T, Kadota J, Saito N, Yoshida T, Okumura H, Ueki T, Nagafuji K, Kako S, Uoshima N, Tsudo M, Itamura H, Fukuda T
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Journal Title
Clin Infect Dis
Volume: 57
Issue: 5
Pages: 671-681
DOI
Related Report
Peer Reviewed
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[Journal Article] Chromosomally integrated human herpesvirus 6: questions and answers2012
Author(s)
Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Lautenschlager I, Loomis KS, Luppi M, Lusso P, Medveczky PG, Montoya JG, Mori Y, Ogata M, Pritchett JC, Rogez S, Seto E, Ward KN, Yoshikawa T, Razonable RR
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Journal Title
Rev Med Virol
Volume: 22
Pages: 144-155
Related Report
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[Presentation] Saliva as a potential route of virus entry into the CNS in HV-6 encephalitis after allogeneic HCT2013
Author(s)
Takata H, Ogata M, Satou T, Honda S, Yoshida N, Nashimoto Y, Moroga Y, Takano K, Ikebe T, Kohno K, shirao K, Kadota J, Ueki T, Kobayashi H, Takeda W, Kirihara T, Sato K, Fujiwara Y, Shimizu I, Hiroshima Y, Sumi M
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Year and Date
2013-10-11
Related Report
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[Presentation] Correlations of cytokine concentration in plasma and CSF with outcome of HHV-6 encephalitis2013
Author(s)
Takano K, Ogata M, Satou T, Shirao K, Kadota J, Miyazaki Y, Saitou N, Ueki T, Okumura H, Nagafuji K, Kako S, Uoshima N, Fukuda T
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Year and Date
2013-10-11
Related Report
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[Presentation] Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation : a multicenter, prospective study2013
Author(s)
Ogata M, Satou T, Kadota J, Saito N, Yoshida T, Okumura H, Ueki T, Nagafuji K, Kako S, Uoshima N, Tsudo M, Itamura H, Fukuda T
Organizer
18^<th> Congress of the European Hematology Association
Place of Presentation
Stockholm
Year and Date
2013-06-13
Related Report
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[Presentation] Human herpesvirus-6 reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study2013
Author(s)
Ogata M, Satou T, Kadota J, Saito N, Okumura H, Ueki T, Nagafuji K, Kako S, Uoshima N, Tsudo M, Itamura H, Fukuda T
Organizer
18th Congress of the European Hematology Association
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] Saliva as a potential route of virus entry into the CNS in HHV-6 encephalitis after allogeneic HCT2013
Author(s)
Takata H, Ogata M, Satou T, Honda S, Yoshida N, Nashimoto Y, Moroga Y, Takano K, Ikebe T, Kohno K, Shirao K, Kadota J, Ueki T, Kobayashi H, Takeda W, Kirihara T, Sato K, Fujiwara Y, Shimizu I, Hiroshima Y, Sumi M
Organizer
第75回日本血液学会学術集会
Place of Presentation
さっぽろ芸文館、ロイトン札幌、札幌市教育文化会館)
Related Report
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[Presentation] Correlations of cytokine concentrations in plasma and CSF with outcome of HHV-6 encephalitis2013
Author(s)
Takano K, Ogata M, Satou T, Shirao K, Kadota J, Miyazaki Y, Saitou N, Ueki T, Okumura H, Nagafuji K, kako S, Uoshima N, Fukuda T
Organizer
第75回日本血液学会学術集会
Place of Presentation
さっぽろ芸文館、ロイトン札幌、札幌市教育文化会館)
Related Report
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[Presentation] Multicenter prospective study of HHV-6 reactivation and its effect on CNS after allogeneic SCT2012
Author(s)
Ogata M, Satou T, Kadota J, Saito M, Ueki T, Yoshida T, Okumura H, Nagafuji K, Kako S, Uoshima N, Tsudo M, Ichinohe T, Fukuda T
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-20
Related Report
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[Presentation] High plasma IL-6 level before HHV-6 reactivation is key factors of HHV-6 encephalitis development2011
Author(s)
Takano K, Ogata M, Satou T, Inoue Y, Moroga Y, Ikebe T, Ando T, Ikewaki J, Kohno K, Saburi M, Nishida A, Miyazaki Y, Ohtsuka E, Saburi Y, Kadota J
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Year and Date
2011-10-14
Related Report
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[Presentation] Multicenter prospective study of HHV-6 reactivation and its effect on CNS after allogeneic SCT
Author(s)
Ogata M, Satou T, Kadota J-i, Saito M, Ueki T, Yoshida T, Okumura H, Nagafuji K, Kato S, Uoshima N, Tsudo M, Ichinohe T, Fukuda T
Organizer
第74回日本血液学会学術集会
Place of Presentation
国立京都国際会館
Related Report
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