| Project/Area Number |
23591422
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Oita University |
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Principal Investigator |
OGATA Masao 大分大学, 医学部, 講師 (10332892)
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| Co-Investigator(Kenkyū-buntansha) |
SATOU Takako 大分大学, 医学部, 研究補佐員 (90420645)
KOHNO Kazuhiro 大分大学, 医学部, 助教 (80420644)
KADOTA Jun-ichi 大分大学, 医学部, 教授 (50233838)
TAKANO Kuniko 大分大学, 医学部, 特任助教 (20617427)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 造血細胞移植 / ヒトヘルペス6 / ヒトヘルペス6脳炎 / サイトカイン / HHV-6 / HHV-6脳炎 / interleukin-6 / interleukineー６ |
|---|
| Research Abstract |
To elucidate the immunological pathogenesis of human herpesvirus (HHV)-6 encephalitis, we performed detailed cytokine study against 172 HCT recipients, including 20 patients with HHV-6 encephalitis. Seventeen kinds of cytokines in plasma samples collected weekly until 28 days after HCT, and cerebrospinal fluid (CSF) at the time of developing HHV-6 encephalitis were measured. The plasma IL-8, -10, -13, MCP-1, and MIP-1b were significantly higher in patients who developed HHV-6 encephalitis than those without HHV-6 encephalitis. High-level IL-6 predicted poor prognosis for patients with HHV-6 encephalitis. Among patients with HHV-6 encephalitis, IL-5, -6, and -8 in CSF were higher in patients who progress to severe status (died of encephalitis or sequelae) than in other patients. We suggest that several cytokines mediate the pathogenesis of HHV-6 encephalitis. Increased levels of cytokines in plasma and CSF predict development and poor prognosis of HHV-6 encephalitis.
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