Negative regulation of TLR signaling by G-CSF and ATP in leukocytes
| Project/Area Number |
23591424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka City University |
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Principal Investigator |
KITAGAWA Seiichi 大阪市立大学, 医学(系)研究科(研究院), 教授 (50133278)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takayuki 大阪市立大学, 大学院医学研究科, 講師 (50343413)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 好中球 / 単球 / リポポリサッカライド / 腫瘍壊死因子α / 顆粒球コロニー刺激因子 / ATP / インターフェロンγ / IL-8 / TLR4 / G-CSF / GM-CSF / IFN-α / IFN-γ / LPS / TNF-alpha / INF-alpha / IFN-gamma |
|---|
| Research Abstract |
Various Toll-like receptors are expressed on human leukocytes such as neutrophils and monocytes, and play an important role in the innate immunity. Although the molecular mechanisms of Toll-like receptor-mediated cell activation have been increasingly understood, the positive and negative regulatory mechanisms on this system remain to be elusive. To elucidate the negative regulatory mechanisms by physiological molecules is particularly important for possible treatment of inflammation and tissue damage. We found that this system was positively regulated by granulocyte-macrophage colony-stimulating factor, interferon-alpha and interferon-gamma, and was negatively regulated by granulocyte colony-stimulating factor and ATP (adenosine tri-phosphate).
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Isolation of diploid baker's yeast capable of strongly activating immune cells and analyses of the cell wall structure2014
Author(s)
Takada Y, Mizobuchi A, Kato T, Kasahara E, Ito C, Watanabe H, Kanzaki K, Kitagawa S, Tachibana T, Azuma M
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Journal Title
Bioscience, Biotechnology and Biochemistr
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] S1-1/RBM10: Multiplicity and cooperativity of nuclear localization domains.2013
Author(s)
Xiao S, Wang L, Kimura M, Kojima H, Kunimoto H, Nishiumi F, Yamamoto N, Nishio K, Fujimoto S, Kato T, Kitagawa S, Yamane H, Nakajima K, Inoue A.
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Journal Title
Biol. Cell
Volume: 105
Issue: 4
Pages: 162-174
DOI
Related Report
Peer Reviewed
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