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Role of recombinant nicked beta2-glycoprotein I domain V in angiogenesis

Research Project

Project/Area Number 23591431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionHokkaido University

Principal Investigator

YASUDA Shinsuke  北海道大学, 医学(系)研究科(研究院), 講師 (00374231)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血管新生 / アンギオスタチン / β2-グリコプロテインI / 抗リン脂質抗体症候群 / 血栓症
Research Abstract

Previously we reported nicked beta2-glycoprotein I (b2GPI) binds to angiostatin via its domain V and exerts pro-angiogenic effect (Nakagawa et al. Blood 2009). The aim of this study was to investigate the role of b2GPI domain V in angiogenesis. Recombinant b2GPI domain V was generated in mammalian cell expression system and bacteria. Purification of the product was done using anti-FLAG column or nickel column. Binding between intact/nicked b2GPI domain V and angiostatin 4.5 (AS4.5) was evaluated using surface plasmon resonance. Nicked b2GPI domain V specifically bound onto AS4.5 at KD of ~ 5 x 10-8M, whereas intact b2GPI domain V showed no specific binding. Cell proliferation assay using human umbilical endothelial cells (HUVECs) were performed in the presence or absence of intact/nicked b2GPI domain V. Both intact and nicked b2GPI domain V slightly inhibited cell proliferation at 0.4uM.
In conclusion, nicked b2GPI domain V bound to AS4.5, as observed in nicked form of whole b2GPI.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (51 results)

All 2014 2013 2012 2011 Other

All Journal Article (33 results) (of which Peer Reviewed: 33 results,  Open Access: 1 results) Presentation (12 results) (of which Invited: 1 results) Book (4 results) Remarks (2 results)

  • [Journal Article] The risk of serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors decreased over time; a report from the registry of Japanese rheumatoid arthritis patients for long-term safety (REAL) database2014

    • Author(s)
      Sakai R, Cho SK, Nanki T, Koike R, Watanabe K, Yamazaki H, Nagasawa H, Amano K, Tanaka Y, Sumida T, Ihata A, Yasuda S, Nakajima A, Sugihara T, Tamura N, Fujii T, Dobashi H, Miura Y, Miyasaka N, Harigai M
    • Journal Title

      Rheumatol Int

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome in Japanese patients with lupus nephritis2014

    • Author(s)
      Kono M, Yasuda S, Kato M, Kanetsuka Y, Kurita T, Fujieda Y, Otomo K, Horita T, Oba K, Kondo M, Mukai M, Yanai M, Fukasawa Y, Atsumi T
    • Journal Title

      Lupus

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis2014

    • Author(s)
      Kurita T, Yasuda S, Oba K, Odani T, Kono M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Amenguak O, Horita T, Atsumi T
    • Journal Title

      Rheumatology (Oxford)

      Volume: (in press)

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of Runx1 and lowered production of Foxp3+ CD25+ CD4+ regulatory T cells in systemic sclerosis2014

    • Author(s)
      Kataoka H, Yasuda S, Fukaya S, Oku K, Horita T, Atsumi T, Koike T
    • Journal Title

      Mod Rheumatol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiphospholipid antibodies2014

    • Author(s)
      Amengual O, Horita T, Binder W, Norman GL, Shums Z, Kato M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Yasuda S, Atsumi T
    • Journal Title

      Rheumatol Int

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] for the RESEARCH investigators; the REAL Study Group. A comparison of incidence and risk factors for serious adverse events in rheumatoid arthritis patients with etanercept or adalimumab in Korea and Japan2014

    • Author(s)
      Cho SK, Sakai R, Nanki T, Koike R, Watanabe K, Yamazaki H, Nagasawa H, Tanaka Y, Nakajima A, Yasuda S, Ihata A, Ezawa K, Won S, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Miyasaka N, Bae SC, Harigai M
    • Journal Title

      Mod Rheumatol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 111(10) Pages: 3787-92

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of Runx1 and lowered production of Foxp3+ CD25+ CD4+ regulatory T cells in systemic sclerosis2014

    • Author(s)
      Kataoka H, Yasuda S, Fukaya S, Oku K, Horita T, Atsumi T, Koike T
    • Journal Title

      Modern Rheumatology

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiphospholipid antibodies2014

    • Author(s)
      Amengual O, Horita T, Binder W, Norman GL, Shums Z, Kato M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Yasuda S, Atsumi T
    • Journal Title

      Rheumatology International

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of incidence and risk factors for serious adverse events in rheumatoid arthritis patients with etanercept or adalimumab in Korea and Japan2014

    • Author(s)
      Cho SK, Sakai R, Nanki T, Koike R, Watanabe K, Yamazaki H, Nagasawa H, Tanaka Y, Nakajima A, Yasuda S, Ihata A, Ezawa K, Won S, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Miyasaka N, Bae SC, Harigai M
    • Journal Title

      Modern Rheumatology

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
    • Journal Title

      Proceedings of National Academy of Science USA

      Volume: 111 Issue: 10 Pages: 3787-3792

    • DOI

      10.1073/pnas.1401105111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential role of p38 mitogen-activated protein kinase pathway in tissue factor gene expression mediated by the phosphatidylserina-dependent antiprothrombin antibody2013

    • Author(s)
      Oku K, Amengual O, Zigon P, Horita T, Yasuda S, Atsumi T
    • Journal Title

      Rheumatology (Oxford)

      Volume: 52(10) Pages: 1775-84

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The involvement of CD36 in monocyte activation by antiphospholipid antibodies2013

    • Author(s)
      Kato M, Atsumi T, Oku K, Amengual O, Nakagawa H, Fujieda Y, Otomo K, Horita T, Yasuda S, Koike T
    • Journal Title

      Lupus

      Volume: 22(8) Pages: 761-71

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disseminated intravascular coagulation in the presence of antiphospholipid antibodies : differential diagnosis from catastrophic or microangiopathic antiphospholipid syndrome2013

    • Author(s)
      Yasuda S
    • Journal Title

      Intern Med

      Volume: 52(2) Pages: 169-70

    • NAID

      130003365862

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome2013

    • Author(s)
      Amengual O, Atsumi T, Oku K, Suzuki E, Horita T, Yasuda S, Koike T
    • Journal Title

      Mod Rheumatol

      Volume: 23(1) Pages: 81-8

    • NAID

      10031167669

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disseminated intravascular coagulation in the presence of antiphospholipid antibodies: differential diagnosis from catastrophic or microangiopathic antiphospholipid syndrome.2013

    • Author(s)
      Yasuda S
    • Journal Title

      Intern Med

      Volume: In press

    • NAID

      130003365862

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Essential role of the p38 mitogen-activated protein kinase pathway in tissue factor gene expression mediated by the phosphatidylserine-dependent antiprothrombin antibody2013

    • Author(s)
      Oku K, Amengual O, Zigon P, Horita T, Yasuda S, Atsumi T
    • Journal Title

      rheumatology (Oxford)

      Volume: In press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predominant prevalence of arterial thrombosis in Japanese patients with the antiphospholipid syndrome2012

    • Author(s)
      Fujieda Y, Atsumi T, Amengual O, Odani T, Otomo K, Kato M, Oku K, Kon Y, Horita T, Yasuda S, Koike T
    • Journal Title

      Lupus

      Volume: 21(14) Pages: 1506-14

    • NAID

      120005356853

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease2012

    • Author(s)
      Odani T, Yasuda S, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T
    • Journal Title

      Rheumatology (Oxford)

      Volume: 51(10) Pages: 1765-74

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events2012

    • Author(s)
      Otomo K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
    • Journal Title

      Arthritis Rheum

      Volume: 64(2) Pages: 504-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease.2012

    • Author(s)
      Odani T, Yasuda S, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T.
    • Journal Title

      rheumatology (Oxford)

      Volume: 51 Pages: 1765-74

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid2012

    • Author(s)
      Fujieda Y, Atsumi T, Amengual O, Odani T, Otomo K, Kato M, Oku K, Kon Y, Horita T, Yasuda S, Koike T
    • Journal Title

      syndromeLupus

      Volume: 21(14) Issue: 14 Pages: 1506-14

    • DOI

      10.1177/0961203312458469

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome2012

    • Author(s)
      Amengual O, Atsumi T, Oku K, Suzuki E, Horita T, Yasuda S, Koike T
    • Journal Title

      Mod Rheumatol

      Volume: 23(1) Issue: 1 Pages: 81-8

    • DOI

      10.1007/s10165-012-0642-9

    • NAID

      10031167669

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events2012

    • Author(s)
      Otomo K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
    • Journal Title

      Arthritis Rheum

      Volume: 64 Issue: 2 Pages: 504-512

    • DOI

      10.1002/art.33340

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis2011

    • Author(s)
      Hashimoto T, Yasuda S, Koide H, Kataoka H, Horita T, Atsumi T, Koike T
    • Journal Title

      Arthritis Res Ther

      Volume: 13(5)

    • NAID

      120003945421

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus reactivation by immunosuppressive therapy in patients with autoimmune diseases : Risk analysis in hepatitis B surface antigen-negative cases2011

    • Author(s)
      Kato M, Atsumi T, Kurita T, Odani T, Fujieda Y, Otomo K, Horita T, Yasuda S, Koike T
    • Journal Title

      J Rheumatol

      Volume: 38(10) Pages: 2209-14

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases : report of five cases and a literatural review2011

    • Author(s)
      Kato M, Kataoka H, Odani T, Fujieda Y, Otomo K, Oku K, Horita T, Yasuda S, Atsumi T, Tsujino I, Nishimura M, Koike T
    • Journal Title

      Lupus

      Volume: 20(10) Pages: 1047-56

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The REAL database reveals no significant risk of serious infection during treatment with a methotrexate dose of more than 8 mg/week in patients with rheumatoid arthritis2011

    • Author(s)
      Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nakajima A, Atsumi T, Yasuda S, Tanaka Y, Saito K, Tohma S, Fujii T, Ihata A, Tamura N, Kawakami A, Sugihara T, Ito S, Miyasaka N, Harigai M
    • Journal Title

      Mod Rheumatol

      Volume: 21(4) Pages: 444-8

    • NAID

      10029513170

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis.2011

    • Author(s)
      Hashimoto T, Yasuda S, Koide H, Kataoka H, Horita T, Atsumi T, Koike T.
    • Journal Title

      Arthritis Res Ther

      Volume: 13 Issue: 5

    • DOI

      10.1186/ar3470

    • NAID

      120003945421

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus reactivation by immunosuppressive therapy in patients with autoimmune diseases: Risk analysis in hepatitis B surface antigen-negative cases.2011

    • Author(s)
      Kato M, Atsumi T, Kurita T, Odani T, Fujieda Y, Otomo K, Horita T, Yasuda S, Koike T.
    • Journal Title

      J Rheumatol

      Volume: 38 Issue: 10 Pages: 2209-2214

    • DOI

      10.3899/jrheum.110289

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases : report of five cases and a literatural review2011

    • Author(s)
      Kato M, Kataoka H, Odani T, Fujieda Y, Otomo K, Oku K, Horita T, Yasuda s, Atsumi T, Tsujino I, Nishimura M, Koike T
    • Journal Title

      Lupus

      Volume: 20 Issue: 10 Pages: 1047-1056

    • DOI

      10.1177/0961203311403347

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus.2011

    • Author(s)
      Fujieda Y, Kataoka H, Odani T, Otomo K, Kato M, Fukaya S, Oku K, Horita T, Yasuda S, Atsumi T, Koike T.
    • Journal Title

      Mod Rheumatol

      Volume: 21 Issue: 3 Pages: 276-281

    • DOI

      10.1007/s10165-010-0386-3

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The REAL database reveals no significant risk of serious infection during treatment with a methotrexate dose of more than 8 mg/week in patients with rheumatoid arthritis.2011

    • Author(s)
      Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nakajima A, Atsumi T, Yasuda S, Tanaka Y, Saito K, Tohma S, Fujii T, Ihata A, Tamura N, Kawakami A, Sugihara T, Ito S, Miyasaka N, Harigai M.
    • Journal Title

      Mod Rheumatol

      Volume: 21 Issue: 4 Pages: 444-448

    • DOI

      10.1007/s10165-011-0421-z

    • NAID

      10029513170

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 強皮症に対する造血幹細胞移植2014

    • Author(s)
      保田晋助
    • Organizer
      第58回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diagnosis and treatment of RA in Japan, Experience and recommendations of using Tocilizumab in general2013

    • Author(s)
      Yasuda S
    • Organizer
      The 6th Rheumatology Meeting in Aubrac
    • Place of Presentation
      Best Western Lagiore, Aubrac, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Role ofβ_2-glycoprotein I Domain V in Angiogenesis2013

    • Author(s)
      Yasuda S, Kubota A, Nakagawa H, Kuroki K, Fujieda Y, Bohgaki T, Amengual O, Horita T, Maenaka K, Atsumi T
    • Organizer
      CORA meeting
    • Place of Presentation
      Novotel Budapest City, Budapest, Hungary
    • Related Report
      2013 Final Research Report
  • [Presentation] 関節リウマチにおけるRasGRP4の発現異常2013

    • Author(s)
      保田晋助
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      京都国際会議場(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of β2-glycoprotein I Domain V in Angiogenesis2013

    • Author(s)
      Yasuda S, Kubota A, Nakagawa H, Kuroki K, Fujieda Y, Bohgaki T, Amengual O, Horita T, Maenaka K, Atsumi T
    • Organizer
      CORA meeting
    • Place of Presentation
      ノボテルブダペストシティ、ブダペスト(ハンガリー)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diagnosis and treatment of RA in Japan2013

    • Author(s)
      Yasuda S
    • Organizer
      The 6th Rheumatology Meeting in Aubrac
    • Place of Presentation
      ベストウエスタンラギオール、オーブラック(フランス)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of b2-glycoprotein I and b2-glycoprotein I domain V in angiogenesis2013

    • Author(s)
      Yasuda S, Kubota A, Nakagawa H, Kuroki K, Fujieda Y, Oku K, Bohgaki T, Amengual O, Horita T, Maenaka K, Atsumi T
    • Organizer
      Controversies in Rheumatology and Autoimmunity
    • Place of Presentation
      ノボテルブダペストシティ(ハンガリー)
    • Related Report
      2012 Research-status Report
  • [Presentation] IL-6 rationale in RA–from bench side2012

    • Author(s)
      Yasuda S
    • Organizer
      AURORA meeting
    • Place of Presentation
      London, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] Haematopoietic stem cell transplantation for interstitial lung diseases in patients with systemic sclerosis; Therapeutic effect and evaluation of up-regulated genes2012

    • Author(s)
      Yasuda S, Odani T, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T
    • Organizer
      The 8^<th> international congress on autoimmunity
    • Place of Presentation
      Palacio de Exposiciones y Congresos de Granada, Granada, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Aberrant expression of Mx1 in T cells from patients with systemic lupus erythematosus2011

    • Author(s)
      Yasuda S, Kono M, Horita T, Atsumi T, Koike T
    • Organizer
      5^<th> Asian congress on autoimmunity
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] Aberrant expression of Mx1 in T cells from patients with systemic lupus erythematosus.2011

    • Author(s)
      Yasuda S, Kono M, Horita T, Atsumi T, Koike T.
    • Organizer
      5th Asian congress on autoimmunity
    • Place of Presentation
      Congress Venue (Singapore)
    • Related Report
      2011 Research-status Report
  • [Presentation] HLA-DRB5* 01:05 as a risk for systemic sclerosis and scleroderma-related interstitial lung disease2011

    • Author(s)
      Yasuda S, Odani T, Otomo K, Kato M, Horita T, Atsumi T, Koike T
    • Organizer
      2011日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ (千葉)
    • Related Report
      2011 Research-status Report
  • [Book] 全身性エリテマトーデスに対する抗体治療–分子標的治療開発の道のりと現状, 別冊医学のあゆみ,抗体医薬Update–開発コンセプトから最新治療実績まで2012

    • Author(s)
      保田晋助,小池隆夫, (中山俊憲・中島裕史編)
    • Total Pages
      146
    • Publisher
      医歯薬出版株式会社, (東京都)
    • Related Report
      2013 Final Research Report
  • [Book] 顕微鏡的多発血管炎, 膠原病の肺合併症診療マニュアル2012

    • Author(s)
      保田晋助, (宮坂信之編)
    • Total Pages
      207
    • Publisher
      医薬ジャーナル社, (大阪市)
    • Related Report
      2013 Final Research Report
  • [Book] 別冊医学のあゆみ, 抗体医薬 Update – 開発コンセプトから最新治療実績まで2012

    • Author(s)
      保田 晋助, 小池 隆夫
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2012 Research-status Report
  • [Book] 顕微鏡的多発血管炎2012

    • Author(s)
      保田 晋助
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.hucc.hokudai.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 北海道大学大学院医学研究科 内科学講座 免疫・代謝内科学分野

    • URL

      http://www.hucc.hokudai.ac.jp/

    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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