• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Sox transcription factors in the onset of autoimmune diseases

Research Project

Project/Area Number 23591432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionChiba University

Principal Investigator

SUTO Akira  千葉大学, 医学(系)研究科(研究院), 特任准教授 (50447306)

Co-Investigator(Kenkyū-buntansha) SUZUKI Kotaro  千葉大学, 医学部附属病院, 講師 (90554634)
Co-Investigator(Renkei-kenkyūsha) NAKAJIMA Hiroshi  千葉大学, 大学院医学研究院, 教授 (00322024)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsTh17 / Sox5 / c-Maf
Research Abstract

Th17 cells play a pathogenic role in autoimmune diseases. It has been shown that IL-6- and/or IL-21-mediated activation of Stat3 is essential for the expression of RORgammat, which is a lineage-specifying transcription factor of Th17 cells. In this study, we find that Sox5 and c-Maf are induced in Th17 cells in a Stat3-dependent manner. Sox5 together with c-Maf induce Th17 cell differentiation as downstream effectors of Stat3 and as upstream inducers of RORgammat. In addition, we find that T cell-specific Sox5-deficient mice exhibit impaired Th17 cell differentiation and are resistant to experimental autoimmune encephalomyelitis and delayed-type hypersensitivity. Taken together, these results suggest that Sox5 and c-Maf cooperatively induce Th17 cell differentiation via the induction of RORgammat as downstream targets of Stat3.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] IL-21-producing c-Maf-expressing CD4+ T cells induce effector CD8+ T cells and enhance autoimmune inflammation in scurfy mice2014

    • Author(s)
      Iwamoto T, Suto A, Tanaka S, Takatori H, Suzuki K, Iwamoto I, Nakajima H
    • Journal Title

      Arthritis Rheumatol

      Volume: (巻不明) Issue: 8 Pages: 2079-2090

    • DOI

      10.1002/art.38658

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] AT-rich interactive domain-containing protein 5a functions as a negative regulator of RORγt-induced Th17 cell differentiation.2014

    • Author(s)
      Saito Y, Kagami SI, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.
    • Journal Title

      Arthritis and Rheumatology

      Volume: 印刷中 Issue: 5 Pages: 1185-94

    • DOI

      10.1002/art.38324

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.2014

    • Author(s)
      Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H
    • Journal Title

      Int Immunol

      Volume: 26 Issue: 2 Pages: 103-114

    • DOI

      10.1093/intimm/dxt047

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-21-producing c-Maf-expressing CD4+ T cells induce effector CD8+ T cells and enhance autoimmune inflammation in scurfy mice2014

    • Author(s)
      Taro Iwamoto, Akira Suto, Shigeru Tanaka, Hiroaki Takatori, Kotaro Suzuki, Itsuo Iwamoto, and Hiroshi Nakajima
    • Journal Title

      Arthritis and Rheumatology

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells.2013

    • Author(s)
      Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H
    • Journal Title

      J Immunol.

      Volume: 19 Issue: 7 Pages: 3614-3623

    • DOI

      10.4049/jimmunol.1300509

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor β.2013

    • Author(s)
      Tanaka S, Suto A, Ikeda K, Sanayama Y, Nakagomi D, Iwamoto T, Suzuki K, Kambe N, Matsue H, Matsumura R, Kashiwakuma D, Iwamoto I, Nakajima H.
    • Journal Title

      Rheumatology

      Volume: 52 Issue: 11 Pages: 1963-1972

    • DOI

      10.1093/rheumatology/ket254

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells2013

    • Author(s)
      Hosokawa J, Suzuki K, Nakagomi D, Tamachi T, Takatori H, Suto A, Nakajima H
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 161 Issue: Suppl. 2 Pages: 37-43

    • DOI

      10.1159/000350357

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] [18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis.2013

    • Author(s)
      Tanaka S et al
    • Journal Title

      Rheumatology

      Volume: 52 Issue: 7 Pages: 1271-1278

    • DOI

      10.1093/rheumatology/ket112

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.2013

    • Author(s)
      Kobayashi Y, Iwata A, Suzuki K, Suto A, Kawashima S, Saito Y, Owada T, Kobayashi M, Watanabe N, Nakajima H.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 26 Issue: 13 Pages: 5121-6

    • DOI

      10.1073/pnas.1222093110

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity.2013

    • Author(s)
      Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H.
    • Journal Title

      J Invest Dermatol.

      Volume: 133 Issue: 3 Pages: 702-702

    • DOI

      10.1038/jid.2012.396

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bucillamine-induced yellow nail in Japanese patients with rheumatoid arthritis : two case reports and a review of 36 reported cases2013

    • Author(s)
      Nakagomi D, Ikeda K, Kawashima H, Kobayashi Y, Suto A, Nakajima H
    • Journal Title

      Rheumatol Int

      Volume: 33 Issue: 3 Pages: 793-7

    • DOI

      10.1007/s00296-011-2241-z

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pre-dinner administration increases the efficacy of proton pump inhibitors on refractory GERD symptoms in connective tissue disease patients.2013

    • Author(s)
      Iwata A, Ikeda K, Hirose K, Takatori H, Takahashi K, Sanayama Y, Tanaka S, Suto A, Nakajima H.
    • Journal Title

      Mod Rheumatol

      Volume: 23 Issue: 2 Pages: 357-364

    • DOI

      10.1007/s10165-012-0662-5

    • NAID

      10031167710

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation2012

    • Author(s)
      Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M
    • Journal Title

      Infect Immun

      Volume: 80 Issue: 11 Pages: 3939-51

    • DOI

      10.1128/iai.00581-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice2012

    • Author(s)
      Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S
    • Journal Title

      Eur J Immunol

      Volume: 42 Issue: 8 Pages: 1999-2009

    • DOI

      10.1002/eji.201142250

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice2011

    • Author(s)
      Oya Y, Watanabe N, Owada T, Oki M, Ikeda K, Suto A, Kagami S-I, Hirose K, Kishimoto T, Nakajima H
    • Journal Title

      Int. Immunol

      Volume: 23 Issue: 5 Pages: 335-44

    • DOI

      10.1093/intimm/dxr017

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis2013

    • Author(s)
      S. Tanaka, K Ikeda, K. Uchiyama, T. Iwamoto, Y. Sanayama, A. Okubo, D. Nakagomi, K. Takahashi, M. Yokota, A. Suto, K. Suzuki, H. Nakajima
    • Organizer
      EULAR Congress 2013
    • Place of Presentation
      マドリッドスペイン
    • Related Report
      2013 Final Research Report
  • [Presentation] [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis.2013

    • Author(s)
      S. Tanaka, K Ikeda, K. Uchiyama, T. Iwamoto, Y. Sanayama, A. Okubo, D. Nakagomi, K. Takahashi, M. Yokota, A. Suto, K. Suzuki, H. Nakajima
    • Organizer
      EULAR (European League Against Rheumatism) Congress 2013
    • Place of Presentation
      Madrid (スペイン)
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.jp/class/allergy/research/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 千葉大学大学院医学研究院 アレルギー・臨床免疫 研究業績

    • URL

      http://www.m.chiba-u.jp/class/allergy/research/index.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi