Role of Sox transcription factors in the onset of autoimmune diseases
Project/Area Number |
23591432
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Chiba University |
Principal Investigator |
SUTO Akira 千葉大学, 医学(系)研究科(研究院), 特任准教授 (50447306)
|
Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kotaro 千葉大学, 医学部附属病院, 講師 (90554634)
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Co-Investigator(Renkei-kenkyūsha) |
NAKAJIMA Hiroshi 千葉大学, 大学院医学研究院, 教授 (00322024)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | Th17 / Sox5 / c-Maf |
Research Abstract |
Th17 cells play a pathogenic role in autoimmune diseases. It has been shown that IL-6- and/or IL-21-mediated activation of Stat3 is essential for the expression of RORgammat, which is a lineage-specifying transcription factor of Th17 cells. In this study, we find that Sox5 and c-Maf are induced in Th17 cells in a Stat3-dependent manner. Sox5 together with c-Maf induce Th17 cell differentiation as downstream effectors of Stat3 and as upstream inducers of RORgammat. In addition, we find that T cell-specific Sox5-deficient mice exhibit impaired Th17 cell differentiation and are resistant to experimental autoimmune encephalomyelitis and delayed-type hypersensitivity. Taken together, these results suggest that Sox5 and c-Maf cooperatively induce Th17 cell differentiation via the induction of RORgammat as downstream targets of Stat3.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] AT-rich interactive domain-containing protein 5a functions as a negative regulator of RORγt-induced Th17 cell differentiation.2014
Author(s)
Saito Y, Kagami SI, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.
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Journal Title
Arthritis and Rheumatology
Volume: 印刷中
Issue: 5
Pages: 1185-94
DOI
Related Report
Peer Reviewed
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[Journal Article] Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor β.2013
Author(s)
Tanaka S, Suto A, Ikeda K, Sanayama Y, Nakagomi D, Iwamoto T, Suzuki K, Kambe N, Matsue H, Matsumura R, Kashiwakuma D, Iwamoto I, Nakajima H.
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Journal Title
Rheumatology
Volume: 52
Issue: 11
Pages: 1963-1972
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity.2013
Author(s)
Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H.
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Journal Title
J Invest Dermatol.
Volume: 133
Issue: 3
Pages: 702-702
DOI
Related Report
Peer Reviewed
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[Journal Article] Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation2012
Author(s)
Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M
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Journal Title
Infect Immun
Volume: 80
Issue: 11
Pages: 3939-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice2012
Author(s)
Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S
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Journal Title
Eur J Immunol
Volume: 42
Issue: 8
Pages: 1999-2009
DOI
Related Report
Peer Reviewed
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[Presentation] [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis2013
Author(s)
S. Tanaka, K Ikeda, K. Uchiyama, T. Iwamoto, Y. Sanayama, A. Okubo, D. Nakagomi, K. Takahashi, M. Yokota, A. Suto, K. Suzuki, H. Nakajima
Organizer
EULAR Congress 2013
Place of Presentation
マドリッドスペイン
Related Report
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[Presentation] [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis.2013
Author(s)
S. Tanaka, K Ikeda, K. Uchiyama, T. Iwamoto, Y. Sanayama, A. Okubo, D. Nakagomi, K. Takahashi, M. Yokota, A. Suto, K. Suzuki, H. Nakajima
Organizer
EULAR (European League Against Rheumatism) Congress 2013
Place of Presentation
Madrid (スペイン)
Related Report
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