Clinicopathogenic significance of CD26/caveolin-1 costimulatory pathway in collagen-vascular diseases

• Project/Area Number: 23591434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: HOSONO Osamu 東京大学, 医科学研究所, 講師 (50190210)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: CD26 / 膠原病 / 共刺激 / Caveolin-1

Research Abstract

Clinicopathogenic significance of T cell costimulatory pathway via caveolin-1/CD26 interaction and serum soluble CD26 in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was examined in this study.
CD26 expression on induced Th17 cells was significantly elevated. Increased Th17 cells and decreased serum level of soluble CD26 was shown in active SLE. Abnormal CD26 costimulatory signal transduction by immobilized caveolin-1-Fc and anti-CD3 monoclonal antibody had not been found in patients with RA and SLE so far. Soluble CD26 might be related with expression of caveolin-1 and CD86 on macrophages. The defective epitope on CD26 was found in some patients by using soluble CD26 measuring ELISA. However, caveolin-1 co-stimulation was not altered in those patients.

Research Products

• [Journal Article] Comparison of Two Commercial ELISAs against an In-House ELISA for Measuring Soluble CD26 in Human Serum. (2015)
  • Author(s): Ohnuma K, Saito T, Hatano R, Hosono O, Iwata S, Dang NH, Ninomiya H, Morimoto C.
  • Journal Title: J Clin Lab Anal. Volume: Vol 29 Issue: 2 Pages: 106-11
  • DOI: 10.1002/jcla.21736
  • Peer Reviewed / Open Access
• [Journal Article] CD26 overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma (2012)
  • Author(s): Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C
  • Journal Title: Clin Cancer Res Volume: 18(5) Pages: 1447-1456
• [Journal Article] Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer (2012)
  • Author(s): Kondo S, Iwata S, Yamada T, Inoue Y, Ichihara H, Kichikawa Y, Katayose T, Souta-Kuribara A, Yamazaki H, Hosono O, Kawasaki H, Tanaka H, Hayashi Y, Sakamoto M, Kamiya K, Dang NH, Morimoto C
  • Journal Title: Clin Cancer Res Volume: 18(22) Pages: 6326-38
• [Journal Article] Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer. (2012)
  • Author(s): Kondo S, Morimoto C, et al.
  • Journal Title: Clin Cancer Res. Volume: 18 Issue: 22 Pages: 6326-6338
  • DOI: 10.1158/1078-0432.ccr-11-2162
  • Peer Reviewed
• [Journal Article] CD26 Overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma (2012)
  • Author(s): Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C
  • Journal Title: Clin Cancer Res Volume: 18(5) Issue: 5 Pages: 1447-1456
  • DOI: 10.1158/1078-0432.ccr-11-1990
  • Peer Reviewed
• [Presentation] 多臓器障害および多彩な免疫異常を呈したIgG4関連疾患の1例 (2013)
  • Author(s): 細野治、上原昌晃、松宮遼、吉川賢忠、小林浩、鈴木幸男、田中廣壽
  • Organizer: 第24回日本リウマチ学会関東支部学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-12-07
• [Presentation] Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis (2012)
  • Author(s): Iwata S, Katayose T, Kichikawa Y, Ichihara H, Kawasaki H, Hosono O, Tanaka H, Morimoto C
  • Organizer: American College of Rheumatology 2011 Annual Scientific Meeting
  • Place of Presentation: In Washington, DC., USA
• [Presentation] Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis. (2012)
  • Author(s): Satoshi Iwata, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Hiroshi Kawasaki, Osamu Hosono, Hirotoshi Tanaka and Chikao Morimoto.
  • Organizer: ACR/ARHP 2012 Annual Meeting
  • Place of Presentation: Washington, DC, USA
• [Presentation] A New Derivative of Roxithromycin Modulates Immunological Responses and Ameliorates Collagen-induced Arthritis (2011)
  • Author(s): Otsuki N, Iwata S, Kumagai E, Yamada T, Katayose T, Kichikawa Y, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C
  • Organizer: American College of Rheumatology 2011 Annual Scientific Meeting
  • Place of Presentation: In Chicago, USA
• [Presentation] A New Derivative of Roxithromycin Modulates Immunological Responses and Ameliorates Collagen-induced Arthritis (2011)
  • Author(s): Noriko Otsuki, Satoshi Iwata, Emi Kumagai, Taketo Yamada, Tomoki Katayose, Yoshiko Kichikawa, Osamu Hosono, Hiroshi Kawasaki, Hirotoshi Tanaka, Nam H. Dang and Chikao Morimoto
  • Organizer: ACR/ARHP 2011 Annual Meeting
  • Place of Presentation: Chicago (USA)
• [Presentation] 多臓器障害および多彩な免疫異常を呈したIgG4関連疾患の１例
  • Author(s): 細野治、上原昌晃、松宮遼、吉川賢忠、小林弘、鈴木幸男、田中廣壽．
  • Organizer: 第24回日本リウマチ学会関東支部学術集会
  • Place of Presentation: 東京