Clinicopathogenic significance of CD26/caveolin-1 costimulatory pathway in collagen-vascular diseases
| Project/Area Number |
23591434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSONO Osamu 東京大学, 医科学研究所, 講師 (50190210)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CD26 / 膠原病 / 共刺激 / Caveolin-1 |
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| Research Abstract |
Clinicopathogenic significance of T cell costimulatory pathway via caveolin-1/CD26 interaction and serum soluble CD26 in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was examined in this study.
CD26 expression on induced Th17 cells was significantly elevated. Increased Th17 cells and decreased serum level of soluble CD26 was shown in active SLE. Abnormal CD26 costimulatory signal transduction by immobilized caveolin-1-Fc and anti-CD3 monoclonal antibody had not been found in patients with RA and SLE so far. Soluble CD26 might be related with expression of caveolin-1 and CD86 on macrophages. The defective epitope on CD26 was found in some patients by using soluble CD26 measuring ELISA. However, caveolin-1 co-stimulation was not altered in those patients.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] CD26 overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma2012
Author(s)
Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C
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Journal Title
Clin Cancer Res
Volume: 18(5)
Pages: 1447-1456
Related Report
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[Journal Article] Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer2012
Author(s)
Kondo S, Iwata S, Yamada T, Inoue Y, Ichihara H, Kichikawa Y, Katayose T, Souta-Kuribara A, Yamazaki H, Hosono O, Kawasaki H, Tanaka H, Hayashi Y, Sakamoto M, Kamiya K, Dang NH, Morimoto C
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Journal Title
Clin Cancer Res
Volume: 18(22)
Pages: 6326-38
Related Report
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[Journal Article] CD26 Overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma2012
Author(s)
Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C
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Journal Title
Clin Cancer Res
Volume: 18(5)
Issue: 5
Pages: 1447-1456
DOI
Related Report
Peer Reviewed
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[Presentation] Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis2012
Author(s)
Iwata S, Katayose T, Kichikawa Y, Ichihara H, Kawasaki H, Hosono O, Tanaka H, Morimoto C
Organizer
American College of Rheumatology 2011 Annual Scientific Meeting
Place of Presentation
In Washington, DC., USA
Related Report
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[Presentation] A New Derivative of Roxithromycin Modulates Immunological Responses and Ameliorates Collagen-induced Arthritis2011
Author(s)
Otsuki N, Iwata S, Kumagai E, Yamada T, Katayose T, Kichikawa Y, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C
Organizer
American College of Rheumatology 2011 Annual Scientific Meeting
Place of Presentation
In Chicago, USA
Related Report
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