The alteration of sugar chain profiling during the differentiation into IL-17-producing helper T cells

• Project/Area Number: 23591438
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kagawa University
• Principal Investigator: OOMIZU Souichi 香川大学, 医学部, 助教 (00444729)
• Co-Investigator(Kenkyū-buntansha): HIRASHIMA Mitsuomi 香川大学, 医学部, 教授 (70109700) ; 仁木 敏朗 香川大学, 医学部, 助教 (40558508)
• Co-Investigator(Renkei-kenkyūsha): NIKI Toshiro 香川大学, 医学部, 助教 (40558508)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ガレクチン９ / Ｔｈ１７細胞 / 糖鎖 / ガレクチン / Th17 / 国際情報交換 / Th17細胞 / ガレクチン9

Research Abstract

It has been reported that the activation of Th17 cells is one of the genesis of autoimmune inflammation. Galectin-9, which is a B-galactoside binding animal lectin inhibits the differentiation of Th17 cells from naive helper T cells. The inhibitory effect of galectin-9 on Th17 differentiation is exerted by binding to the O-linked protein that is relatively specific. Furthermore helper T cells that express galectin-9 on the surface highly secrete galectin 9, and inhibit the differentiation Th17 cells.

Research Products

• [Journal Article] Self-association of the galectin-9 C-terminal domain via the opposite surface of the sugar-binding site (2013)
  • Author(s): Nonaka, Y., Ogawa, T., Oomizu, S., Nakakita, S., Nishi, N., Kamitori, S., Hirashima, M. & Nakamura, T
  • Journal Title: J. Biochem Volume: 153 Issue: 5 Pages: 463-471
  • DOI: 10.1093/jb/mvt009
  • Peer Reviewed
• [Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages (2012)
  • Author(s): Kadowaki T
  • Journal Title: Clin Immunol Volume: 142(3) Issue: 3 Pages: 296-307
  • DOI: 10.1016/j.clim.2011.11.006
  • Peer Reviewed
• [Journal Article] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner (2012)
  • Author(s): Oomizu S
  • Journal Title: Clin Immunol Volume: 143(1) Issue: 1 Pages: 51-8
  • DOI: 10.1016/j.clim.2012.01.004
  • Peer Reviewed
• [Journal Article] Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice (2012)
  • Author(s): S. Katoh, S. Oomizu, T. Niki, H. Shimizu, Y. Obase, M. Korenga, M. Oka, M. Hirashima
  • Journal Title: International Archives of Allergy and Immunology Volume: 158(Suppl. 1) Issue: Suppl. 1 Pages: 58-65
  • DOI: 10.1159/000337769
• [Journal Article] Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion. (2012)
  • Author(s): Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hattori T, Masaki T, Hirashima M.
  • Journal Title: PLoS One Volume: 7 Issue: 11 Pages: 1-10
  • DOI: 10.1371/journal.pone.0048574
  • Peer Reviewed
• [Journal Article] Galectin-9 Attenuates Acute Lung Injury by Expanding CD14^- Plasmacytoid Dendritic Cell-Like Macrophages (2011)
  • Author(s): K. Kojima, T. Arikawa, N. Saita, E. Goto, Tsumura, R. Tanaka, A. Masunaga, T. Niki, S. Oomizu, M. Hirashima, H. Kohrogi
  • Journal Title: American journal of respiratory and critical care medicine Volume: 184(3) Issue: 3 Pages: 328-39
  • DOI: 10.1164/rccm.201010-1566oc
• [Presentation] Critical role of galectin-9 but not IL-10 from Type1 regulatory T cells to regulate T helper 17 cell development (2011)
  • Author(s): S. Oomizu, T. Arikawa, T. Niki, K. Kadowaki, N. Nishi, A. Yamauchi, M. Hirashima
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 千葉
• [Presentation] Galectin-9 switches monocyte differentiation to plasmacytoid dendritic cell-like macrophages to prolong the survival of lung cancer-bearing mice (2011)
  • Author(s): K. Kadowaki, T. Arikawa, S. Oomizu, H. Inagawa, M. Hirashima
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 千葉
• [Presentation] Critical role of galectin-9 but not IL-10 from Type1 regulatory T cells to regulate T helper 17 cell development. (2011)
  • Author(s): 大水総一
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉市
• [Patent(Industrial Property Rights)] ガレクチン9を分泌する細胞、その製造方法及びその用途 (2011)
  • Inventor(s): 有川智広、平島光臣、門脇健、仁木 敏朗、大水総一
  • Industrial Property Rights Holder: 株式会社ガルファーマ
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-12-09
  • Overseas