Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Research Abstract |
It has been reported that the activation of Th17 cells is one of the genesis of autoimmune inflammation. Galectin-9, which is a B-galactoside binding animal lectin inhibits the differentiation of Th17 cells from naive helper T cells. The inhibitory effect of galectin-9 on Th17 differentiation is exerted by binding to the O-linked protein that is relatively specific. Furthermore helper T cells that express galectin-9 on the surface highly secrete galectin 9, and inhibit the differentiation Th17 cells.
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