Investigation of autoantigens in patients with rheumatoid arthritis through protemic analysis: exploration from diagnosis, pathogenesis to therapy
Project/Area Number |
23591439
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Nagasaki University |
Principal Investigator |
KAWAKAMI Atsushi 長崎大学, 医歯(薬)学総合研究科, 教授 (90325639)
|
Co-Investigator(Kenkyū-buntansha) |
ORIGUCHI Tomoki 長崎大学, 大学院医歯薬学総合研究科, 教授 (90295105)
ABIRU Norio 長崎大学, 大学院医歯薬学総合研究科, 准教授 (00380981)
OHYAMA Kaname 長崎大学, 大学院医歯薬学総合研究科, 准教授 (50437860)
TAMAI Mami 長崎大学, 大学院医歯薬学総合研究科, 講師 (60380862)
ARIMA Kazuhiko 長崎大学, 大学院医歯薬学総合研究科, 講師 (30423635)
YAMASAKI Satoshi 広島大学, 大学病院, 助教 (30367388)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | リウマチ学 / RA / 滑膜細胞 / TSP-1 / TGF-β1 / VEGF / サイトカイン/増殖因子 / 疾患活動性 / パワードプラ / サイトカイン/増殖因子 / seronegative RA / イムノコンプレキソーム / LC-MS/MS / PF-4 / FLS / サイトカイン・増殖因子 |
Research Abstract |
Serum immune complexome analysis has found that TSP-1 and PF-4 are candidate autoantigens in RA. Especially, TSP-1 was considered as more useful than PF-4 in terms of detection sensitivity. In fact, prominent expression of TSP-1 was found in RA synovial tissues. TSP-1 was spontaneously produced in RA synovial cells and TGF- beta1 significantly stimulated the synthesis of TSP-1 at transcriptional level. A clear reduction of plasma TSP-1 and TGF- beta1 was found in RA patients successfully treated by disease-modifying anti-rheumatic drugs (DMARDs), however, the above change was not determined in RA patients DMARDs did not improve the clinical disease activity. It has been reported that the inflammatory niche of rheumatoid synovial tissues contain high TGF- beta1. We suspect that TGF- beta1 acts on synovial cells to produce TSP-1, and furthermore, the augmented production of TSP-1 may stimulate the autoantibody production toward TSP-1 in patients with RA.
|
Report
(4 results)
Research Products
(71 results)
-
[Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis : power Doppler subclinical synovitis is associated with bone erosion2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
-
Journal Title
Rheumatology (Oxford)
Volume: 53(3)
Pages: 562-9
NAID
Related Report
Peer Reviewed
-
[Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis.2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
-
Journal Title
Rheumatology (Oxford).
Volume: -
Issue: 8
Pages: 1452-1456
DOI
Related Report
Peer Reviewed
-
[Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion.2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
-
Journal Title
Rheumatology (Oxford).
Volume: 53
Issue: 3
Pages: 562-569
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis2013
Author(s)
Kawashiri SY, Suzuki T, Okada A, Yamasaki S, Tamai M, Nakamura H, Origuchi T, Mizokami A, Uetani M, Aoyagi K, Eguchi K, Kawakami A
-
Journal Title
Mod Rheumatol
Volume: 23(1)
Pages: 36-43
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] 関節リウマチ患者における抗リウマチ薬治療による関節超音波パワードプラスコアと血管新生因子血清濃度の改善2013
Author(s)
川尻真也,鈴木貴久,中島好一,寶來吉朗,岩本直樹,一瀬邦弘,中村英樹,川上純,玉井慎美,折口智樹,有馬和彦,青柳潔
-
Journal Title
九州リウマチ
Volume: 33 (2)
Pages: 74-80
Related Report
Peer Reviewed
-
[Journal Article] 関節リウマチ患者におけるエタネルセプト治療による関節超音波所見の改善2013
Author(s)
川尻真也,鈴木貴久,中島好一,寶來吉朗,岩本直樹,一瀬邦弘,中村英樹,川上純,玉井慎美,折口智樹,有馬和彦,青柳潔
-
Journal Title
九州リウマチ
Volume: 33(1)
Pages: 15-21
Related Report
Peer Reviewed
-
-
[Journal Article] Serum amyloid A (SAA) induces pentraxin 3 (PTX3) production in rheumatoid synoviocytes.2013
Author(s)
Satomura K, Torigoshi T, Koga T, Maeda Y, Izumi Y, Jiuchi Y, Miyashita T, Yamasaki S, Kawakami A, Aiba Y, Nakamura M, Komori A, Sato J, Ishibashi H, Motokawa S, Migita K.
-
Journal Title
Mod Rheumatol.
Volume: 23
Issue: 1
Pages: 28-35
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] 関節リウマチ患者における抗リウマチ薬治療による関節超音波パワードプラスコアと血管新生因子血清濃度の改善2013
Author(s)
川尻 真也, 鈴木 貴久, 中島 好一, 寶來 吉朗, 岩本 直樹, 一瀬 邦弘, 中村 英樹, 川上 純, 玉井 慎美, 折口 智樹, 有馬 和彦, 青柳 潔
-
Journal Title
九州リウマチ
Volume: 33
Pages: 74-80
Related Report
Peer Reviewed
-
-
[Journal Article] Magnetic resonance imaging (MRI)detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis : comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI-based findings2012
Author(s)
Tamai M, Kawakami A, Uetani M, Fukushima A, Arima K, Fujikawa K, Iwamoto N, Aramaki T, Kamachi M, Nakamura H, Ida H, Origuchi T, Aoyagi K, Eguchi K
-
Journal Title
Modern Rheumatology
Volume: 22
Pages: 654-658
NAID
Related Report
Peer Reviewed
-
-
-
[Journal Article] Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration2012
Author(s)
Kita J, Tamai M, Arima K, Nakashima Y, Suzuki T, Kawashiri SY, Iwamoto N, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
-
Journal Title
Mod Rheumatol
Volume: 22(3)
Pages: 346-52
NAID
Related Report
Peer Reviewed
-
[Journal Article] Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors2012
Author(s)
Kita J, Tamai M, Arima K, Nakashima Y, Suzuki T, Kawashiri SY, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Aramaki T, Nakashima M, Fujikawa K, Tsukada T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
-
Journal Title
Mod Rheumatol
Volume: 22(2)
Pages: 195-201
NAID
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells2011
Author(s)
Koga T, Yamasaki S, Migita K, Kita J, Okada A, Kawashiri S, Iwamoto N, Tamai M, Arima K, Origuchi T, Nakamura H, Osaki M, Tsurumoto T, Shindo H, Eguchi K, Kawakami A
-
Journal Title
Clin Exp Rheumatol
Volume: 29(6)
Pages: 906-12
Related Report
Peer Reviewed
-
[Journal Article] Soluble urokinase plasminogen activator receptor as a useful biomarker to predict the response to adalimumab in patients with rheumatoid arthritis in a Japanese population2011
Author(s)
Koga T, Okada A, Kawashiri SY, Kita J, Suzuki T, Nakashima Y, Tamai M, Satoh K, Origuchi T, Iwamoto N, Yamasaki S, Nakamura H, Migita K, Ida H, Ueki Y, Eguchi K, Kawakami A
-
Journal Title
Clin Exp Rheumatol
Volume: 29(5)
Pages: 811-5
Related Report
Peer Reviewed
-
-
-
[Journal Article] Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration2011
Author(s)
Kita J, Tamai M(筆頭共著者), ArimaK, Nakashima Y, Suzuki T, Kawashiri SY, Iwamoto N, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
-
Journal Title
Mod Rheumatol
Volume: (E-pub)
Issue: 3
Pages: 346-352
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis : comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaaceticacid (Gd-DTPA)-enhanced MRI-based findings2011
Author(s)
Tamai M, Kawakami A, Uetani M, Fukushima A, Arima K, Fujikawa K, Iwamoto N, Aramaki T, Kamachi M, Nakamura H, Ida H, Origuchi T, Aoyagi K, Eguchi K
-
Journal Title
Mod Rheumatol
Volume: (E-pub)
Issue: 5
Pages: 654-658
DOI
Related Report
Peer Reviewed
-
[Journal Article] Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drags shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors2011
Author(s)
Kita J, Tamai M(筆頭共著者), ArimaK, Nakashima Y, Suzuki T, Kawashiri SY, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Aramaki T, Nakashima M, Fujikawa K, Tsukada T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
-
Journal Title
Mod Rheumatol
Volume: (E-pub)
Issue: 2
Pages: 195-201
DOI
Related Report
Peer Reviewed
-
[Journal Article] The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease activity and level of serum biomarkers in patients with rheumatoid arthritis2011
Author(s)
Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Satoh K, Tamai M, Nakamura H, Okada A, Koga T, Yamasaki S, Ida H, Origuchi T, Eguchi K.
-
Journal Title
Rheumatology (Oxford)
Volume: 50(5)
Issue: 5
Pages: 962-965
DOI
Related Report
Peer Reviewed
-
[Journal Article] Reduction in serum levels of substance P in patients with rheumatoid arthritis by etanercept, a tumor necrosis factor inhibitor.2011
Author(s)
Origuchi T, Iwamoto N, Kawashiri SY, Fujikawa K, Tamai M, Arima K, Nakamura H, Kawakami A, Ueki Y, Matsuoka N, Nakashima M, Mizokami A, Kawabe Y, Mine M, Fukuda T, Eguchi K, et al.
-
Journal Title
Mod Rheumatol
Volume: 21 (3)
Issue: 3
Pages: 244-250
DOI
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] In rheumatoid arthritis patients treated with tocilizumab, the rate of clinical disease activity index (CDAI) remission at 24 weeks is superior in those with higher titers of IgM-rheumatoid factor at baseline.2011
Author(s)
Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Yamasaki S, Nakamura H, Origuchi T, Ueki Y, Migita K, Mizokami A, Aoyagi K, Eguchi K.
-
Journal Title
Mod Rheumatol
Volume: 21 (4)
Issue: 4
Pages: 370-374
DOI
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells.2011
Author(s)
Koga T, Yamasaki S, Migita K, Kita J, Okada A, Kawashiri S, Iwamoto N, Tamai M, Arima K, Origuchi T, Nakamura H, Osaki M, Tsurumoto T, Shindo H, Eguchi K, Kawakami A.
-
Journal Title
Clin Exp Rheumatol
Volume: 29 (6)
Pages: 906-912
Related Report
Peer Reviewed
-
-
[Presentation] 関節リウマチ(RA)患者におけるメトトレキサート(MTX)投与による関節超音波画像の検討2013
Author(s)
鈴木貴久,川尻真也,西野文子,高谷亜由子,中島好一,寳來吉朗,岡田覚丈,岩本直樹,一瀬邦弘,玉井慎美,有馬和彦,中村英樹,折口智樹,江口勝美,川上純
Organizer
第28回日本臨床リウマチ学会
Place of Presentation
埼玉県入間郡
Related Report
-
-
-
[Presentation] 関節リウマチ滑膜組織におけるThrombospondin-1(TSP-1)の重要性と調節機能の検討2013
Author(s)
鈴木貴久,山崎聡士,中島好一,寳來吉朗,岡田覚丈,川尻真也,岩本直樹,一瀬邦弘,玉井慎美,有馬和彦,中村英樹,折口智樹,尾崎誠,大山要,黒田直敬,植木幸孝,江口勝美,川上純
Organizer
第34回日本炎症・再生医学会
Place of Presentation
京都市
Related Report
-
[Presentation] 関節リウマチ(RA)患者の滑膜におけるtransforming growth factorβ1(TGF-β1)によるthrombospondin-1(TSP-1)産生機構の検討:TSP-1を含む血清免疫複合体がなぜRA患者で認められるのか2013
Author(s)
鈴木貴久,山崎聡士,中島好一,寳來吉朗,岡田覚丈,川尻真也,岩本直樹,一瀬邦弘,玉井慎美,有馬和彦,中村英樹,折口智樹,植木幸孝,川上純
Organizer
第57回日本リウマチ学会総会・学術集会
Place of Presentation
京都市
Related Report
-
-
-
[Presentation] 関節リウマチ(RA)患者の滑膜におけるtransforming growth factor β1(TGF-β1)によるthrombospondin-1(TSP-1)産生機構の検討:TSP-1を含む血清免疫複合体がなぜRA患者で認められるのか2013
Author(s)
鈴木貴久, 山崎聡士, 中島好一, 寳來吉朗, 岡田覚丈, 川尻真也, 岩本直樹, 一瀬邦弘, 玉井慎美, 有馬和彦, 中村英樹, 折口智樹, 植木幸孝, 川上 純.
Organizer
第57回日本リウマチ学会総会・学術集会
Place of Presentation
国立京都国際会館(京都市)
Related Report
-
-
[Presentation] HE SEVERITY OF SYNOVIAL INFLAMMATION ASSESSED BY MUSCULOSKELETAL ULTRASONOGRAPHY CORRELATES WITH THAT OF OSTEITIS ASSESSED BY MAGNETIC RESONANCE IMAGING IN PATIENTS WITH RHEUMATOID ARTHRITIS.2013
Author(s)
Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
Organizer
Annual European Congress of Rheumatology 2013
Place of Presentation
Feria de Madrid (Madrid,spain)
Related Report
-
[Presentation] 関節リウマチ滑膜組織におけるThrombospondin-1(TSP-1)の重要性と調節機能の検討.2013
Author(s)
鈴木貴久, 山崎聡士, 中島好一, 寳來吉朗, 岡田覚丈, 川尻真也, 岩本直樹,一瀬邦弘, 玉井慎美, 有馬和彦,中村英樹,折口智樹, 尾崎 誠,大山 要, 黒田直敬, 植木幸孝,江口勝美, 川上 純.
Organizer
第34回日本炎症・再生医学会
Place of Presentation
国立京都国際会館(京都市)
Related Report
-
-
-
[Presentation] 関節リウマチ(RA)患者におけるメトトレキサート(MTX)投与による関節超音波画像の検討2013
Author(s)
鈴木貴久, 川尻真也, 西野文子, 高谷亜由子, 中島好一, 寳來吉朗, 岡田覚丈, 岩本直樹, 一瀬邦弘, 玉井慎美, 有馬和彦, 中村英樹, 折口智樹, 江口勝美, 川上 純.
Organizer
第28回日本臨床リウマチ学会
Place of Presentation
幕張メッセ(千葉市)
Related Report
-
-
[Presentation] 関節リウマチ予後における関節MRI2012
Author(s)
玉井慎美,有馬和彦,上谷雅孝,岩本直樹,岡田覚丈,喜多潤子,川尻真也,一瀬邦弘,中村英樹,折口智樹,青柳潔,江口勝美,川上純
Organizer
第40回日本臨床免疫学会
Place of Presentation
東京都
Related Report
-
-
-
-
[Presentation] 臨床的寛解に到達した関節リウマチ患者における関節エコー所見の意義の検討2012
Author(s)
川尻真也,西野文子,鈴木貴久,中島好一,寳來吉朗,岡田覚丈,一瀬邦弘,玉井慎美,中村英樹,折口智樹,江口勝美,川上純
Organizer
第56回日本リウマチ学会総会・学術総会
Place of Presentation
東京
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-