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Reprograming of rheumatoid synovial cell function by miRNA

Research Project

Project/Area Number 23591440
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionHiroshima University (2012-2013)
Nagasaki University (2011)

Principal Investigator

YAMASAKI Satoshi  広島大学, 大学病院, 病院助教 (30367388)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Eiji  広島大学, 病院, 教授 (70179167)
KAWAKAMI Atsushi  長崎大学, 医歯(薬)学総合研究科, 教授 (90325639)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsリウマチ学 / マイクロRNA / 関節リウマチ / 滑膜細胞 / TGF / miRNA / 分化誘導 / 翻訳制御 / locked nucleic acid / サイトカイン / mRNA崩壊 / 受容体
Research Abstract

We identified miRNAs, which are induced in fibroblastic synovial cell from a patients with rheumatoid arthritis by treatment with TGFbeta1, a cytokine produced from immune cells. One of the miRNAs targets a transcript of secrete protein, which can be secreted form fibroblastic synovial cell. This implies that a miRNA induced by TGFbeta1 can reduce the secreted protein expression in rheumatoid arthritis. Since the secreted protein is involved in osteoblastgenic process, the miRNA is thought to contribute to osteoblast function in the disease. Namely, a method that regulate this miRNA may leads to enhancement of the bone regeneration process in destructed articular bone in rheumatoid arthritis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (9 results)

  • [Journal Article] Improvement of plasma endothelin-1 and nitric oxide in patients with systemic sclerosis by bosentan therapy.2014

    • Author(s)
      Kawashiri SY, Ueki Y, Terada K, Yamasaki S, Aoyagi K, Kawakami A.
    • Journal Title

      Rheumatol Int.

      Volume: 34 Issue: 2 Pages: 221-5

    • DOI

      10.1007/s00296-013-2861-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis2012

    • Author(s)
      Okada A, Yamasaki S, Koga T, Kawashiri SY, Tamai M, Origuchi T, Nakamura H, Eguchi K, Kawakami A
    • Journal Title

      Clin Exp Rheumatol

      Volume: 30 Pages: 332-7

    • URL

      http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=22325242

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM.2012

    • Author(s)
      Koga T, Fujikawa K, Horai Y, Okada A, Kawashiri SY, Iwamoto N, Suzuki T, Nakashima Y, Tamai M, Arima K, Yamasaki S, et al.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 51 Issue: 7 Pages: 1278-84

    • DOI

      10.1093/rheumatology/ker518

    • NAID

      120006985654

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis.2012

    • Author(s)
      Okada A, Yamasaki S, Koga T, Kawashiri SY, Tamai M, Origuchi T, Nakamura H, Eguchi K, Kawakami A.
    • Journal Title

      Clin Exp Rheumatol.

      Volume: 30 Pages: 332-7

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome.2012

    • Author(s)
      Origuchi T, Arima K, Kawashiri SY, Tamai M, Yamasaki S, Nakamura H, Tsukada T, Aramaki T, Furuyama M, Miyashita T, Kawabe Y, Iwanaga N, Terada K, Ueki Y, Fukuda T, Eguchi K, Kawakami A.
    • Journal Title

      Mod Rheumatol.

      Volume: 22 Issue: 4 Pages: 584-8

    • DOI

      10.1007/s10165-011-0556-y

    • NAID

      10031027205

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells.2011

    • Author(s)
      Koga T, Yamasaki S, Migita K, Kita J, Okada A, Kawashiri S, Iwamoto N, Tamai M, Arima K, Origuchi T, Nakamura H, Osaki M, Tsurumoto T, Shindo H, Eguchi K, Kawakami A.
    • Journal Title

      Clin Exp Rheumatol.

      Volume: 29 Pages: 906-912

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 脂肪分化誘導による滑膜細胞からのマトリックスメタロプロテアーゼ産生抑制2013

    • Author(s)
      山崎聡士、遠藤功二、熊谷和彦、野島祟樹、杉山英二
    • Organizer
      第41回日本臨床免疫学会総会
    • Place of Presentation
      海峡メッセ下関,山口市
    • Year and Date
      2013-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes in MMPs in Fibroblast-Like Synoviocytes Following Adipogenesis2013

    • Author(s)
      Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama
    • Organizer
      79th American College of Rheumatology
    • Place of Presentation
      San Diego Convention Center,San Diego,USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪分化誘導による滑膜細胞からのマトリックスメタロプロテアーゼ産生抑制2013

    • Author(s)
      山崎聡士、岡田覚丈、遠藤功二、大岩寛、野島祟樹、熊谷和彦、川上純、杉山英二
    • Organizer
      第57回日本リウマチ学会総会学術集会
    • Place of Presentation
      京都国際会館、京都(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 関節リウマチ(RA)患者の滑膜におけるtransforming growth factorβ1(TGF-β1)によるthrombospondin-1(TSP-1)産生機構の検討:TSP-1を含む血清免疫複合体がなぜRA患者で認められるのか2013

    • Author(s)
      鈴木貴久、山崎聡士、中島好一、寶來吉朗、岡田覚丈、川尻真也、岩本直樹、一瀬邦弘、玉井慎美、有馬和彦、中村英樹、折口智樹、植木幸孝、川上純
    • Organizer
      第57回日本リウマチ学会総会・学術集会 第22回国際リウマチシンポジウム
    • Place of Presentation
      国立京都国際会館,京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 肪分化誘導による 滑膜細胞からのマトリックスメタロプロテアーゼ産生抑制2013

    • Author(s)
      山崎聡士、岡田覚丈、遠藤功二、大岩 寛、野島祟樹、熊谷和彦、川上 純、杉山英二.
    • Organizer
      第57回日本リウマチ学会総会学術集会
    • Place of Presentation
      京都国際会館、京都.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Changes in MMPs in Fibroblast-Like Synoviocytes Following Adipogenesis2013

    • Author(s)
      Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama.
    • Organizer
      2013 ACR/ARHP Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 滑膜細胞におけるKruppel-like factor 4の機能解析2012

    • Author(s)
      山崎聡士、岡田覚丈、一瀬邦弘、中村英樹、川尻真也、玉井慎美、鈴木貴久、折口智樹、川上純
    • Organizer
      第56回日本リウマチ学会総会・学術集会 第21回国際リウマチシンポジウム
    • Place of Presentation
      グランドプリンスホテル新高輪,東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 滑膜細胞におけるKruppel-like factor 4の機能解析2012

    • Author(s)
      山崎聡士, 岡田覚丈, 一瀬邦弘, 中村英樹, 川尻真也, 玉井慎美, 鈴木貴久, 寳來吉朗, 折口智樹, 川上純.
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      東 京 グランドプリンスホテル新高輪
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional Changes of Bone Marrow-derived Mesenchymal Stem Cell Through Adipogenesis2011

    • Author(s)
      Satoshi Yamasaki, Akitomo Okada, Atsushi Kawakami
    • Organizer
      The 75th Annual Meeting of the American College of Rheumatology
    • Place of Presentation
      Chicago, USA,
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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