Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Research Abstract |
Mechanisms of granuloma formation in autoimmune diseases is unknown. We found that transcription factor IRF4-deficient lupus-prone MRL/lpr mice develop granulomas with Langhans giant cells in multiple organs including lung. We also found that IRF4-deficient MRL/lpr mice had increased numbers of IFN-g-producing Th1 cells with elevated levels of serum IFN-g. While, transcription factor IRF1-deficient MRL/lpr mice had increased numbers of IL-4-producing Th2 cells and granulomas with foreign body giant cells in their lung. Our data indicate that transcription factor IRF4 and IRF1 play important roles to maintain Th1/Th2-cell/cytokine balance, and defect of these transcription factors causes development of granulomatous lesions in multiple organs.
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