| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In order to delineate the mechanism of polyclonal B cell activation, we first explore the mechanism of suppression of B cell by activated T cells using the system with immobilized anti-CD3. Although it was suggested that interactions between CTLA4 on T cells and CD80/86 on B cells might involve in the suppression, we could not get direct evidence.
We also examined whether IgG type autoantibodies might be produced in cultures with immobilized anti-CD3 stimulated mitomycin C-treated T cells and B cells. However, none of IgG anti-DNA, anti-Sm, anti-RNP were produced. Nor could we induce class switch of IgM anti-DNA to IgG anti-DNA with monocytes or alpha-interferon.
Further studies are required to investigate the mechanism of production of IgG anti-DNA.
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