Clarification of the etiopathogenesis of IgG4-related disease: Establishment of a mouse model based on abnormal T cell functional abnormalities

• Project/Area Number: 23591460
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kanazawa University
• Principal Investigator: KAWANO Mitsuhiro 金沢大学, 大学病院, 講師 (20361983)
• Co-Investigator(Kenkyū-buntansha): YAMADA Kazunori 金沢大学, 大学病院, 助教 (90397224)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: IgG4関連疾患 / モデルマウス / APRIL / Th2

Research Abstract

We evaluated whether Lat Y136F knock-in mice, which show Th2 predominant immunoreaction with increased serum IgG1, a counterpart of human IgG4, are a novel mice model for IgG4-related disease (IgG4-RD). Lat Y136F knock-in mice showed a similar pathology to that of human IgG4-RD in kidney, pancreas and salivary glands, and a good response to corticosteroid. These results suggested that Lat Y136F knock-in mice are a novel mice model for IgG4-RD. Next, we analyzed the role of APRIL in IgG4-RD using Lat Y136F knock-in mice. We administered APRIL blocking antibody to Lat Y136F knock-in mice, and found that the inflammation in kidney in an APRIL blocking antibody group was significantly decreased as compared to that in a control group. This result indicated that APRIL plays some role in the promotion of lesions at least in IgG4-related kidney disease.

Research Products

• [Journal Article] Analysis of pancreatic endocrine function in patients with IgG4-related diseases, in whom autoimmune pancreatitis was ruled out by diagnostic imaging (2014)
  • Author(s): Ito N, Yagi K, Kawano M, Mori Y, Okazaki S, Chujo D, Takeda Y, Kobayashi J, Yamagishi M
  • Journal Title: Endocrine Journal Volume: (in press)
  • NAID: 130004684904
  • Peer Reviewed
• [Journal Article] A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration (2014)
  • Author(s): Hara S, Kawano M, Mizushima I, Yamada K, Fujita K, Harada K, Matsumura M, Yamagishi M, Sato Y, Yamaguchi Y, Nakanuma Y, Nagata M
  • Journal Title: Mod Rheumatol Volume: (in press)
  • NAID: 120007135033
  • Peer Reviewed
• [Journal Article] IgG4-related kidney disease (2014)
  • Author(s): Saeki T, Kawano M
  • Journal Title: Kidney Int Volume: 85(2) Issue: 2 Pages: 251-257
  • DOI: 10.1038/ki.2013.393
  • NAID: 40017420481
  • Peer Reviewed
• [Journal Article] Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. (2014)
  • Author(s): Aga M, Kondo S, Yamada K, Wakisaka N, Yagi-Nakanishi S, Tsuji A, Endo K, Murono S, Ito M, Muramatsu M, Kawano M, Yoshizaki T
  • Journal Title: Hum Pathol Volume: 45(4) Issue: 4 Pages: 793-801
  • DOI: 10.1016/j.humpath.2013.11.012
  • Peer Reviewed
• [Journal Article] Investigations of IgG4-related disease involving the skin (2013)
  • Author(s): Yamada K, Hamaguchi Y, Saeki T, Yagi K, Ito N, Kakuchi Y, Yamagishi M, Takehara K, Nakanuma Y, Kawano M
  • Journal Title: Mod Rheumatol Volume: 23(5) Issue: 5 Pages: 986-93
  • DOI: 10.1007/s10165-012-0786-7
  • NAID: 10031201158
  • Peer Reviewed
• [Journal Article] The clinical course of patients with IgG4-related kidney disease (2013)
  • Author(s): Saeki T, Kawano M, Mizushima I, Yamamoto M, Wada Y, Nakashima H, Homma N, Tsubata Y, Takahashi H, Ito T, Yamazaki H, Saito T, Narita I
  • Journal Title: Kidney Int Volume: 84(4) Issue: 4 Pages: 826-33
  • DOI: 10.1038/ki.2013.191
  • Peer Reviewed
• [Journal Article] Henoch-Schönlein purpura nephritis in a patient with IgG4-related disease: A possible association (2013)
  • Author(s): Ito K, Yamada K, Mizushima I, Aizu M, Fujii H, Mizutomi K, Matsumura M, Hayashi K, Yamagish M, Umehara H, Yamaguchi Y, Nagata M, Kawano M
  • Journal Title: Clin Nephrol Volume: 79(3) Issue: 03 Pages: 246-252
  • DOI: 10.5414/cn107114
  • Peer Reviewed
• [Journal Article] Primary Sjögren's syndrome with chronic tubulointerstitial nephritis and lymphadenopathy mimicking IgG4-related disease (2013)
  • Author(s): Kawano M, Suzuki Y, Yamada K, Mizushima I, Matsumura M, Nakajima K, Yamagishi M, Yamaguchi Y
  • Journal Title: Mod Rheumatol Volume: (Epub ahead of print) Issue: 4 Pages: 637-641
  • DOI: 10.3109/14397595.2013.844303
  • Peer Reviewed
• [Journal Article] Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases. (2013)
  • Author(s): Kawano M, Mizushima I, Yamaguchi Y, Imai N, Nakashima H, Nishi S, Hisano S, Yamanaka N, Yamamoto M, Takahashi H, Umehara H, Saito T, Saeki T.
  • Journal Title: Int J Rheumatol. Volume: Epub ahead of print Pages: 609795-609795
  • DOI: 10.1155/2012/609795
  • Peer Reviewed
• [Journal Article] Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. (2013)
  • Author(s): Masaki Y, Kurose N, Yamamoto M, ,Yamada K, Kawano M, ,Eguchi K, Sugai S, Umehara H.
  • Journal Title: Int J Rheumatol. Volume: Epub ahead of print Pages: 580814-580814
  • DOI: 10.1155/2012/580814
  • Peer Reviewed
• [Journal Article] Clinical Aspects of IgG4-Related Orbital Inflammation in a Case Series of Ocular Adnexal Lymphoproliferative Disorders. (2013)
  • Author(s): Takahira M, Ozawa Y, Kawano M, Zen Y, Hamaoka S, Yamada K, Sugiyama K.
  • Journal Title: Int J Rheumatol Volume: Epub ahead of print Pages: 635473-635473
  • DOI: 10.1155/2012/635473
  • NAID: 120004161529
  • Peer Reviewed
• [Journal Article] Prurigo nodularis-like skin eruptions in a patient with IgG4-related disease (2013)
  • Author(s): Hamaguchi Y, Yamada K, Kawano M, Fujimoto M, Takehara K
  • Journal Title: Eur J Dermatol Volume: 23(4) Issue: 4 Pages: 541-542
  • DOI: 10.1684/ejd.2013.2077
  • Peer Reviewed
• [Journal Article] Investigations of IgG4-related disease involving the skin. (2013)
  • Author(s): Yamada K, Hamaguchi Y, Saeki T, Yagi K, Ito N, Kakuchi Y, Yamagishi M, Takehara K, Nakanuma Y, Kawano M.
  • Journal Title: Mod Rheumatol. Volume: Epub ahead of print
  • NAID: 10031201158
  • Peer Reviewed
• [Journal Article] Consensus statement on the pathology of IgG4-related disease. (2013)
  • Author(s): Deshpande V, Zen Y, Chan JK, ,Kawano M, ,Zamboni G, Umehara H, Stone JH.
  • Journal Title: Mod Pathol. Volume: 25(9)
  • Peer Reviewed
• [Journal Article] IgG4-Related disease: recommendations for the nomenclature of this condition and its individual organ system manifestations. (2012)
  • Author(s): Stone JH, Khosroshahi A, Deshpande V, Chan JK, Kawa S et al.
  • Journal Title: Arthritis Rheum Volume: 64 Issue: 10 Pages: 3061-7
  • DOI: 10.1002/art.34593
  • Peer Reviewed
• [Journal Article] Consensus statement on the pathology of IgG4-related disease (2012)
  • Author(s): Deshpande V, Zen Y, Chan JK, , Kawa S. et al.
  • Journal Title: Mod Pathol Volume: on line Issue: 9 Pages: 1181-92
  • DOI: 10.1038/modpathol.2012.72
  • Peer Reviewed
• [Journal Article] Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis (2012)
  • Author(s): Mizushima I, Yamada K, Fujii H, Inoue D, Umehara H, Yamagishi M, Yamaguchi Y, Nagata M, Matsumura M, Kawano M
  • Journal Title: Mod Rheumatol Volume: 22(6) Pages: 859-70
  • NAID: 10031127240
  • Peer Reviewed
• [Journal Article] Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis. (2012)
  • Author(s): Mizushima I, Yamada K, Fujii H, Inoue D, Umehara H, Yamagishi M, Yamaguchi Y, Nagata M, Matsumura M, Kawano M.
  • Journal Title: Mod Rheumatol. Volume: 22(6) Issue: 6 Pages: 859-870
  • DOI: 10.1007/s10165-011-0589-2
  • NAID: 10031127240
  • Peer Reviewed
• [Journal Article] Characteristic tubulointerstitial nephritis in IgG4-related disease (2012)
  • Author(s): Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M; Japanesestudy group on IgG4-related nephropathy
  • Journal Title: Hum Pathol Volume: 43(4) Issue: 4 Pages: 536-49
  • DOI: 10.1016/j.humpath.2011.06.002
  • Peer Reviewed
• [Journal Article] Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD). (2012)
  • Author(s): Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S. et al.
  • Journal Title: Mod Rheumatol Volume: 22 Issue: 1 Pages: 21-30
  • DOI: 10.1007/s10165-011-0571-z
  • Peer Reviewed
• [Journal Article] A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. (2012)
  • Author(s): Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M et al
  • Journal Title: Mod Rheumatol Volume: 22(1) Pages: 1-14
  • NAID: 10030206539
  • Peer Reviewed
• [Journal Article] Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. (2012)
  • Author(s): Umehara H, Okazaki K, Masaki Y, Kawano M et al.
  • Journal Title: Mod Rheumatol Volume: 22(1) Pages: 21-30
  • NAID: 10030206683
  • Peer Reviewed
• [Journal Article] Light-microscopic characteristics of IgG4-related tubulointerstitial nephritis: distinction from non-IgG4-related tubulointerstitial nephritis. (2012)
  • Author(s): Yoshita K, Kawano M, Mizushima I, Hara S, Ito Y, Imai N, Ueno M, Nishi S, Nomura H, Narita I, Saeki T.
  • Journal Title: Nephrol Dial Transplant Volume: in press
  • Peer Reviewed
• [Journal Article] Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis. (2012)
  • Author(s): Mizushima I, Yamada K, Fujii H, Inoue D, Umehara H, Yamagishi M, Yamaguchi Y, Nagata M, Matsumura M, Kawano M.
  • Journal Title: Mod Rheumatol Volume: in press
  • NAID: 10031127240
  • Peer Reviewed
• [Journal Article] Proposal for diagnostic criteria for IgG4-related kidney disease (2011)
  • Author(s): Kawano M, et al
  • Journal Title: Clin Exp Nephrol Volume: 15 Issue: 5 Pages: 615-626
  • DOI: 10.1007/s10157-011-0521-2
  • Peer Reviewed
• [Journal Article] IgG4-related tubulointerstitial nephritis and hepatic inflammatory pseudotumor without hypocomplementemia (2011)
  • Author(s): Kim F, Yamada K, Inoue D, Nakajima K, Mizushima I, Kakuchi Y, Fujii H, Narumi K, Matsumura M, Umehara H, Yamagishi M, Kawano M
  • Journal Title: Intern Med Volume: 50(11) Pages: 1239-44
  • NAID: 130000770479
  • URL: https://www.jstage.jst.go.jp/article/internalmedicine/50/11/50_11_1239/_article
  • Peer Reviewed
• [Journal Article] IgG4-related Tubulointerstitial Nephritis and Hepatic Inflammatory Pseudotumor without Hypocomplementemia (2011)
  • Author(s): Kim F, Yamada K, Inoue D, Nakajima K, Mizushima I, Kakuchi Y, Fujii H, Narumi K, Matsumura M, Umehara H, Yamagishi M, Kawano M.
  • Journal Title: Internal Medicine Volume: 50 Issue: 11 Pages: 1239-1244
  • DOI: 10.2169/internalmedicine.50.5102
  • NAID: 130000770479
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Characteristic tubulointerstitial nephritis in IgG4-related disease. (2011)
  • Author(s): Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M; Japanese study group on IgG4-related nephropathy.
  • Journal Title: Hum Pathol Volume: 43 (4) Pages: 536-549
  • Peer Reviewed
• [Journal Article] Proposal for diagnostic criteria for IgG4-related kidney disease. (2011)
  • Author(s): Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, Yamanaka N, Inoue D, Yamamoto M, Takahashi H, Nomura H, Taguchi T, Umehara H, Makino H, Saito T.
  • Journal Title: Clin Exp Nephrol Volume: 15(5) Pages: 615-26
  • NAID: 10030340628
  • Peer Reviewed
• [Journal Article] IgG4-related skin disease, a mimic of angiolymphoid hyperplasia with eosinophilia. (2011)
  • Author(s): Hamaguchi Y, Fujimoto M, Matsushita Y, Kitamura-Sawada S, Kawano M, Takehara K.
  • Journal Title: Dermatology Volume: 223(4) Pages: 301-5
  • Peer Reviewed
• [Journal Article] IgG4-related Skin Lesions in a Patient with IgG4-related Chronic Sclerosing Dacryoadenitis and Sialoadenitis (2011)
  • Author(s): Kakuchi Y, Yamada K, Suzuki Y, Ito N, Yagi K, Matsumura M, Yamagishi M, Umehara H, Zen Y, Hasegawa M, Takehara K, Kawano M
  • Journal Title: Internal Medicine Volume: 50 Issue: 14 Pages: 1465-1469
  • DOI: 10.2169/internalmedicine.50.5239
  • NAID: 130000969423
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] IgG4関連腎臓病診療指針 (2011)
  • Author(s): 川野充弘、佐伯敬子、中島衡、西愼一、山口裕、久野敏、斉藤喬雄、山中宣昭、田口尚、槇野博史、梅原久範
  • Journal Title: 日腎会誌 Volume: 53(8) Pages: 1062-1073
  • NAID: 10030343670
• [Presentation] Inhibition of APRIL suppresses disease progression : Analysis from a novel mouse model for IgG4-related disease (2014)
  • Author(s): Kazunori Yamada, Masahiko Zuka, Kiyoaki Ito, Yasunori Suzuki, Yasushi Kakuchi, Tamehito Onoe, Masakazu Yamagishi, and Mitsuhiro Kawano
  • Organizer: The 2nd International Symposium on IgG4-Related Diseases & Associated Conditions
  • Place of Presentation: HONOLULU, U.S.A
• [Presentation] Abundant APRIL-Producing Macrophages in IgG4-related Kidney Disease (2014)
  • Author(s): Kazunori Yamada, Takahiro Kawakami, Ichiro Mizushima, Ryoko Hamano, Hiroshi Fujii, Masakazu Yamagishi, and Mitsuhiro Kawano
  • Organizer: The 2nd International Symposium on IgG4-Related Diseases & Associated Conditions
  • Place of Presentation: HONOLULU, U.S.A
• [Presentation] Overview of New Entities within the IgG4-RD spectrum (2014)
  • Author(s): Mitsuhiro Kawano
  • Organizer: Second International Symposium on IgG4 & Related Disease
  • Place of Presentation: HONOLULU, U.S.A
• [Presentation] Abundant APRIL-Producing Macrophages in IgG4-related Kidney Disease (2014)
  • Author(s): Kazunori Yamada, Takahiro Kawakami, Ichiro Mizushima, Ryoko Hamano, Hiroshi Fujii, Masakazu Yamagishi, and Mitsuhiro Kawano
  • Organizer: Second International Symposium on IgG4 & Related Disease
  • Place of Presentation: Honolulu, USA
• [Presentation] Inhibition of APRIL suppresses disease progression: Analysis from a novel mouse model for IgG4-related disease (2014)
  • Author(s): Kazunori Yamada, Masahiko Zuka, Kiyoaki Ito, Yasunori Suzuki, Yasushi Kakuchi, Tamehito Onoe, Masakazu Yamagishi, and Mitsuhiro Kawano
  • Organizer: Second International Symposium on IgG4 & Related Disease
  • Place of Presentation: Honolulu, USA
• [Presentation] Overview of New Entities within the IgG4-RD spectrum (2014)
  • Author(s): Mitsuhiro Kawano
  • Organizer: Second International Symposium on IgG4 & Related Disease, Feb 17, 2014
  • Place of Presentation: Honolulu, USA
  • Invited
• [Presentation] Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study (2014)
  • Author(s): Ichiro Mizushima, Dai Inoue, Motohisa Yamamoto, Kazunori Yamada, Takako Saeki, Yoshifumi Ubara, Shoko Matsui, Yasufumi Masaki, Takashi Wada, Satomi Kasashima, Kenichi Harada, Hiroki Takahashi, Kenji Notohara, Yasuni Nakanuma, Hisanori Umehara, Masakazu Yamagishi, and Mitsuhiro Kawano
  • Organizer: Second International Symposium on IgG4 & Related Disease, Feb 17, 2014
  • Place of Presentation: Honolulu, USA
• [Presentation] Inhibition of APRIL suppresses disease progression in an IgG4-related disease mice model (2013)
  • Author(s): Kazunori Yamada, Masahiko Zuka, Kiyoaki Ito, Yasunori Suzuki, Yasushi Kakuchi, Tamehito Onoe, Masami Matsumura, Masakazu Yamagishi, Shozo Izui, Bertrand Huard, Marie Malissen, Bernard Malissen and Mitsuhiro Kawano
  • Organizer: 12th International Symposium on Sjögren's syndrome
  • Place of Presentation: Kyoto Hotel Okura, Kyoto, Japan
• [Presentation] シェーグレン症候群の腎病変(IgG4関連腎臓病との比較).シンポジウム1シェーグレン症候群の臓器病変と腺病変の最前線 (2013)
  • Author(s): 川野充弘
  • Organizer: 第22回日本シェーグレン症候群学会
  • Place of Presentation: ブリーゼプラザ,大阪
• [Presentation] IgG4関連疾患の病態形成におけるAPRILの関与:モデルマウスを用いた検討 (2013)
  • Author(s): 山田和徳,塚正彦,伊藤清亮,小野江為人,鈴木康倫,水島伊知郎,濱野良子,藤井博,松村正巳,川野充弘
  • Organizer: 第22回日本シェーグレン症候群学会
  • Place of Presentation: ブリーゼプラザ,大阪
• [Presentation] リウマチ・膠原病疾患におけるIgG4関連疾患.ランチョンセミナーII (2013)
  • Author(s): 川野充弘
  • Organizer: 第25回中部リウマチ学会
  • Place of Presentation: 金沢
• [Presentation] IgG4関連腎臓病.シンポジウム17 IgG4関連疾患 (2013)
  • Author(s): 川野充弘
  • Organizer: 第57回日本リウマチ学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Clinical characteristics and the course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis (2013)
  • Author(s): Ichiro Mizushima, Dai Inoue, Kazunori Yamada, Takako Saeki, Yoshifumi Ubara, Yasunori Suzuki, Hiroshi Fujii, Masami Matsumura, Masakazu Yamagishi, Kenji Notohara, Mitsuhiro Kawano.
  • Organizer: Annual European Congress of Rheumatology 2013
  • Place of Presentation: Madrid, Spain
• [Presentation] Inhibition of APRIL suppresses disease progression in an IgG4-related disease mice model (2013)
  • Author(s): Yamada K, Zuka M, Ito K, Suzuki Y, Kakuchi Y, Onoe T, Matsumura M, Yamagishi M, Izui S, Huard B, Malissen M, Malissen B, Kawano M.
  • Organizer: 12th International Symposium on Sjögren's Syndrome
  • Place of Presentation: Kyoto, Japan
• [Presentation] Histopathological analysis of IgG4-related kidney disease: hints from an autopsy series of 5 cases (2013)
  • Author(s): Ichiro Mizushima, Mitsuhiro Kawano, Takako Saeki, Yoshifumi Ubara, Nobuya Ohara, Yasuharu Sato, Kazunori Yamada, Hitoshi Nakashima, Shinichi Nishi, Yutaka Yamaguchi, Satoshi Hisano, Nobuaki Yamanaka, Michio Nagata, and Takao Saito.
  • Organizer: ASN Kidney Week 2013
  • Place of Presentation: Atlanta, USA
• [Presentation] Prurigo nodularis-like skin eruptions in a patient with IgG4-related disease (2013)
  • Author(s): Fujimoto M, Hamaguchi Y, Yamada K, Kawano M, Takehara K.
  • Organizer: 12th International Symposium on Sjögren's Syndrome
  • Place of Presentation: Kyoto, Japan
• [Presentation] IgG4-related Disease : Initial Discovery, Evolving Concepts, Up-to-date Knowledge, role of a proliferation inducing ligand(APRIL) (2012)
  • Author(s): Mitsuhiro Kawano
  • Organizer: Special Seminar:IgG4-related Disease
  • Place of Presentation: University of Geneva, Geneva, Switzerland
  • Year and Date: 2012-06-05
• [Presentation] (2012)
  • Author(s): Takahiro Kawakami, Kazunori Yamada, Ichiro Mizushima, Hiroshi Fujii, Kiyoaki Ito, Shozo Izui, Bertrand Huard, and Mitsuhiro Kawano
  • Organizer: Kidney Week 2012
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] IgG4関連腎臓病におけるAPRIL発現の検討 (2012)
  • Author(s): 山田和徳,川上貴裕,水島伊知郎,鈴木康倫,藤井博,松村正巳,能登原憲司,川野充弘
  • Organizer: 第21回日本シェーグレン症候群学会
  • Place of Presentation: ウェスティン都ホテル京都,京都市
• [Presentation] IgG4関連疾患におけるステロイド維持療法期の再発の検討.ワークショップ71 IgG4関連疾患1 (2012)
  • Author(s): 川野充弘,山田和徳,水島伊知郎,鈴木康倫,谷悠紀子,川村里佳,濱野良子,藤井博,松村正
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] Abundant APRIL-Producing Macrophages in IgG4-related Kidney Disease (2012)
  • Author(s): Takahiro Kawakami, Kazunori Yamada, Ichiro Mizushima, Hiroshi Fujii, Kiyoaki Ito, Shozo Izui, Bertrand Huard, and Mitsuhiro Kawano
  • Organizer: American Society of Nephrology Kidney Week 2012
  • Place of Presentation: San Diego Convention Center (USA)
• [Presentation] IgG4関連炎症性腹部大動脈瘤におけるマクロファージ、APRILの関与 (2012)
  • Author(s): 水島伊知郎、笠島里美、川上貴裕、山田和徳、藤井博、林研至、川尻剛照、松村正巳、川野充弘、山岸正和
  • Organizer: 第16回日本心血管内分泌代謝学会
  • Place of Presentation: 東京大学本郷キャンパス（東京都）
• [Presentation] IgG4陽性形質細胞浸潤を伴う間質性腎炎を呈した原発性Sjogren症候群の1例 (2012)
  • Author(s): 鈴木康倫，蔵島乾，松永貴弘，川村里佳，浜野良子，水島伊知郎，藤井博，山田和徳，松村正巳，川野充弘
  • Organizer: 第21回日本シェーグレン症候群学会学術集会
  • Place of Presentation: ウェスティン都ホテル（京都府）
• [Presentation] 腫大を伴う典型的なIgG4関連疾患病変における、日本の包括診断基準、病理診断Consensus statement基準の妥当性に関する検討 (2012)
  • Author(s): 水島伊知郎，山田和徳，川上貴裕，松永貴弘，鈴木康倫，藤井博，松村正巳，川野充弘
  • Organizer: 第21回日本シェーグレン症候群学会学術集会
  • Place of Presentation: ウェスティン都ホテル（京都府）
• [Presentation] IgG4関連腎臓病の免疫組織学的解析 (2012)
  • Author(s): 川野充弘，水島伊知郎，佐伯敬子，斉藤喬雄，IgG4関連腎臓病ワーキンググループ
  • Organizer: 第55回日本腎臓学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] IgG4関連疾患 バイオマーカーによる診断 (2012)
  • Author(s): 川野充弘
  • Organizer: 第24回日本アレルギー学会春期臨床大会
  • Place of Presentation: 大阪国際会議場（大阪府）
  • Invited
• [Presentation] IgG4関連疾患におけるステロイド維持療法の検討 (2012)
  • Author(s): 川野充弘，山田和徳，水島伊知郎，鈴木康倫，谷悠紀子，川村里佳，浜野良子，藤井博，松村正巳
  • Organizer: 第56回日本リウマチ学会総会・学術総会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] Proposal for diagnostic criteria for IgG4-related kidney disease (2011)
  • Author(s): Mitsuhiro Kawano
  • Organizer: International Symposium for IgG4-related disease
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2011-09-10
• [Presentation] IgG4関連動脈周囲炎
  • Author(s): 川野充弘，笠島里美
  • Organizer: 第17回血管病理研究会
  • Place of Presentation: 山王病院山王ホール（東京都）
  • Invited
• [Presentation] IgG4関連腎臓病診断基準とアルゴリズム（案）の作成
  • Author(s): 川野充弘
  • Organizer: 第54回日本腎臓学会総会(招待講演)
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Proposal for diagnostic criteria for IgG4-related kidney disease (IgG4-RKD)
  • Author(s): Mitsuhiro Kawano, Takako Saeki, Working group for IgG4-related kidney disease (IgG4-RKD)
  • Organizer: 第20回日本シェーグレン症候群学会(招待講演)
  • Place of Presentation: ホテル金沢（金沢）
• [Presentation] 新規IgG4関連疾患モデルマウスの樹立
  • Author(s): 山田和徳、塚正彦、覚知泰志、藤井博、松村正巳、川野充弘
  • Organizer: 第20回日本シェーグレン症候群学会
  • Place of Presentation: ホテル金沢（金沢）
• [Presentation] IgG4関連腎臓病
  • Author(s): 川野充弘
  • Organizer: 第41回日本腎臓学会西部学術大会(招待講演)
  • Place of Presentation: あわぎんホール（徳島）
• [Presentation] Proposal for diagnostic criteria for IgG4-related kidney disease
  • Author(s): M Kawano, T Saeki, H Nakashima, S Nishi, Y Yamaguchi, S Hisano, N Yamanaka, D Inoue, M Yamamoto, H Takahashi, H Nomura, T Taguchi, H Umehara, H Makino, and T Saito
  • Organizer: International IgG4-RD Symposium
  • Place of Presentation: Massachusetts General Hospital and the Holiday Inn Boston at Beacon Hill (Boston, USA)
• [Presentation] Clinical utility of minor salivary gland biopsy to diagnose IgG4-related disease
  • Author(s): K Yamada, M Kawano, I Mizushima, S Hara, Y Kakuchi, H Fujii, Y Waseda, M Takahira, M Yamagishi, and M Matsumura
  • Organizer: International IgG4-RD Symposium
  • Place of Presentation: Massachusetts General Hospital and the Holiday Inn Boston at Beacon Hill (Boston, USA)
• [Book] IgG4-Related Disease (2013)
  • Author(s): Hisanori Umehara, Kazuichi Okazaki, John H. Stone, Shigeyuki Kawa, Mitsuhiro Kawano
  • Total Pages: 237
  • Publisher: Springer
• [Book] IgG4関連疾患アトラス (2012)
  • Author(s): 川茂幸、川野充弘
  • Total Pages: 199
  • Publisher: 前田書店