| Project/Area Number |
23591462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Osaka University |
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Principal Investigator |
HAGIHARA Keisuke 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (60423183)
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| Co-Investigator(Kenkyū-buntansha) |
室田 浩之 , 医学系研究科 ( 研究院 ) (90363499)
田中 敏郎 , 医学系研究科 ( 研究院 ) (40273651)
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| Co-Investigator(Renkei-kenkyūsha) |
松原 広己
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺高血圧症 / レイノー症状 / サイトカイン / エンドセリン受容体拮抗薬 / ＰＤＥ５阻害薬 / 国際情報交換 |
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| Research Abstract |
We performed randomized controlled trials with PDE-5 inhibitors and bosentan for Raynaud's symptoms in the collagen disease patients with PAH.We found that fingers'temperature significantly increased in the cold water test after treatment of PDE-5 inhibitors and bosentan. We confirmed that physical function, vitality, mental in the bosentan group significantly improved using SF-36 QOL questionnaire.Next, we examined the cytokine profiling between primary PAH and secondary PAH with collagen disease using Bio-plex cytokine array.We found that the expression of IL-7, Eotaxin, IL-12p40, IL-16, TRAIL, HGF, and IFN-a2 were significantly differed. he logistic regression analysis using age, HGF, and SCGFb clearly showed that collagen diseases, CETPH and IPAH were distinguished if we measured above cytokines.
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