The role of IL-25 receptor expressed on eosinophil lineage-committed progenitor
Project/Area Number |
23591463
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 大学院医学研究院, 教授 (80380385)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | IL-25 / IL-33 / 好酸球前駆細胞 / 好塩基球前駆細胞 / 肥満細胞前駆細胞 / 顆粒球/単球系前駆細胞 / IL-17RB / IL-17B |
Research Abstract |
Recently, we revealed that eosinophil lineage-committed progenitor (EoP) express both receptors for IL-25 and IL-33, which are members of epithelial cell-derived cytokines, but the role of these rececptors remain unknown. IL-33 stimulated EoP produced Th2 and pro-inflammtory cytokines, such as IL-4, 6, 13, suggesting that IL-33-stimulated EoP may serve not only as progenitor cell in eosinophil development but also as effector cell in allergic inflammation. Intraperitoneal administration of IL-25 and IL-33 induced the exclusive expansion of EoP and mature eosinophils, suggesting that both cytokines should be critical regulators in eosinophil hematopoiesis.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] The cytotoxic effects of certolizumab pegol and golimumab mediated by transmenbrane tumor necrosis factorα2013
Author(s)
Ueda N, Tsukamoto H, Mitoma H, Ayano M, Tanaka A, Ohta S, Inoue Y, Arinobu Y, Niiro H, Akashi K, Horiuchi T
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Journal Title
Inflamm Bowel Dis
Volume: 19
Pages: 1224-1231
Related Report
Peer Reviewed
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[Journal Article] The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α.2013
Author(s)
Ueda N, Tsukamoto H, Mitoma H, Ayano M, Tanaka A, Ohta S, Inoue Y, Arinobu Y, Niiro H, Akashi K, Horiuchi T.
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Journal Title
Inflamm Bowel Dis.
Volume: 19
Issue: 6
Pages: 1224-1231
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity2012
Author(s)
Tanaka A, Tsukamoto H, Mitoma H, Kiyohara C, Ueda N, Ayano M, Ohta SI, Inoue Y, Arinobu Y, Niiro H, Horiuchi T, Akashi K
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Journal Title
Arthritis Res Ther
Volume: 14
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Peer Reviewed
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[Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells2012
Author(s)
Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, Akashi K
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Journal Title
Blood
Volume: 119
Pages: 2263-3372
Related Report
Peer Reviewed
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[Journal Article] Hereditary angioedema in Japan : genetic analysis of 13 unrelated cases2012
Author(s)
Yamamoto T, Horiuchi T, Miyahara H, Yoshizawa S, Maehara J, Shono E, Takamura K, Machida H, Tsujioka K, Kaneko T, Uemura N, Suzawa K, Inagaki N, Umegaki N, Kasamatsu Y, Hara A, Arinobu Y, Inoue Y, Niiro H, Kashiwagai Y, Harashima SI, Tahira T, Tsukamoto H, Akashi K
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Journal Title
Am J Medical Sci
Volume: 343
Pages: 210-214
Related Report
Peer Reviewed
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[Journal Article] Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity.2012
Author(s)
Tanaka A, Tsukamoto H, Mitoma H, Kiyohara C, Ueda N, Ayano M, Ohta SI, Inoue Y, Arinobu Y, Niiro H, Horiuchi T, Akashi K.
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Journal Title
Arthritis Res Ther.
Volume: 14
Issue: 6
Pages: R244-R244
DOI
Related Report
Peer Reviewed
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[Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.2012
Author(s)
Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, Akashi K.
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Journal Title
Blood
Volume: 119
Pages: 2263-2273
Related Report
Peer Reviewed
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[Journal Article] Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis : predominant reconstitution of Th1 CD4+ T cells2011
Author(s)
Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K
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Journal Title
Rheumatology
Volume: 50
Pages: 944-952
Related Report
Peer Reviewed
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[Journal Article] Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells.2011
Author(s)
Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K
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Journal Title
Rheumatology
Volume: 50
Pages: 944-952
Related Report
Peer Reviewed
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