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Clarification of the mechanisms of intracellular trafficking of TNF

Research Project

Project/Area Number 23591464
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKyushu University

Principal Investigator

HORIUCHI Takahiko  九州大学, 大学病院, 教授 (90219212)

Co-Investigator(Kenkyū-buntansha) TAHIRA Tomoko  九州大学, 生体防御医学研究所, 講師 (50155230)
TSUKAMOTO Hiroshi  九州大学, 大学院医学研究院, 准教授 (70304772)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
KeywordsTNF / サイトカイン / 輸送
Research Abstract

In the present study, we studied the mechanisms for intracellular trafficking of TNF, which is a crucial step for TNF production and secretion. By using human-derived cell lines, the effects of the inhibition and/or overproduction of the members of SNARE family on the TNF production and secretion was analyzed. STX4, VAMP3 and Vti1b were involved in the intracellular trafficking of TNF.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (47 results)

All 2014 2013 2012 2011 Other

All Journal Article (35 results) (of which Peer Reviewed: 35 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] the Kyushu Sapporo SLE (KYSS) Study Group : The modifying effect of NAT2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages2014

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y
    • Journal Title

      Arthritis Care Res(Hoboken)

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms involved in the inflammatory response and lung cancer risk : a case-control study in Japan2014

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
    • Journal Title

      Cytokine

      Volume: 65(1) Pages: 88-94

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms involved in the inflammatory response and lung cancer risk: a case-control study in Japan2014

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
    • Journal Title

      Cytokine

      Volume: 65 Issue: 1 Pages: 88-94

    • DOI

      10.1016/j.cyto.2013.09.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced carotid intima-media thickness in systemic lupus erythematosus patients treated with cyclosporine A2014

    • Author(s)
      Oryoji K, Kiyohara C, Horiuchi T, Tsukamoto H, Niiro H, Shimoda T, Akashi K, Yanase T
    • Journal Title

      Mod Rheumatol

      Volume: 24 Pages: 86-92

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn's disease through affecting the ADCC activity2013

    • Author(s)
      Moroi R, Endo K, Kinouchi Y, Shiga H, Kakuta Y, Kuroha M, Kanazawa Y, Shimodaira Y, Horiuchi T,Takahashi S, Shimosegawa T
    • Journal Title

      Immunogenetics

      Volume: 65(4) Pages: 265-271

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factorα2013

    • Author(s)
      Ueda N, Tsukamoto H, Mitoma H, Ayano M, Tanaka A, Ohta S-I, Inoue Y, Arinobu Y, Niiro H, Akashi K, Horiuchi T
    • Journal Title

      Inflamm. Bowel Dis

      Volume: 19(6) Pages: 1224-1231

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and risk factors of vertebral fracture in Japanese females with systemic lupus erythematosus2013

    • Author(s)
      Furukawa M, Kiyohara C, Horiuchi T, Tsukamoto H, Mitoma H, Kimoto Y, Uchino A, Nakagawa M, Oryoji K, Shimoda T, Harada M, Akashi K
    • Journal Title

      Mod. Rheumatol

      Volume: 23(4) Pages: 765-773

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn’s disease through affecting the ADCC activity2013

    • Author(s)
      Moroi R, Endo K, Kinouchi Y, Shiga H, Kakuta Y, Kuroha M, Kanazawa Y, Shimodaira Y, Horiuchi T, Takahashi S, Shimosegawa T
    • Journal Title

      Immunogenetics

      Volume: 65 Issue: 4 Pages: 265-271

    • DOI

      10.1007/s00251-013-0679-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α.2013

    • Author(s)
      Ueda N, Tsukamoto H, Mitoma H, Ayano M, Tanaka A, Ohta S, Inoue Y, Arinobu Y, Niiro H, Akashi K, Horiuchi T.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 19 Issue: 6 Pages: 1224-1231

    • DOI

      10.1097/mib.0b013e318280b169

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and risk factors of vertebral fracture in Japanese females with systemic lupus erythematosus2013

    • Author(s)
      Furukawa M, Kiyohara C, Horiuchi T, Tsukamoto H, Mitoma H, Kimoto Y, Uchino A, Nakagawa M, Oryoji K, Shimoda T, Harada M, Akashi K
    • Journal Title

      Mod. Rheumatol

      Volume: 23 Issue: 4 Pages: 765-773

    • DOI

      10.1007/s10165-012-0735-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum progranulin levels are elevated in patients with systemic lupus erythematosus,reflecting disease activity2012

    • Author(s)
      Tanaka A, Tsukamoto H, Mitoma H, Kiyohara C, Ueda N, Ayano M, Ohta SI, Inoue Y, Arinobu Y, Niiro H, Horiuchi T, Akashi K
    • Journal Title

      Arthritis Res. Ther

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells2012

    • Author(s)
      Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota S-I, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, Akashi K
    • Journal Title

      Blood

      Volume: 119(10) Pages: 2263-2273

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical factors to predict a poor prognosis and refractory disease in patients with polymyositis and dermatomyositis associated with interstitial lung disease2012

    • Author(s)
      Tada Y, Suematsu E, Ueda A, Nagano S, Sawabe T, Nishizaka H, and Horiuchi T
    • Journal Title

      Clin. Exp. Rheumatol

      Volume: 30(3) Pages: 450-450

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking, alcohol consumption and the risk of systemic lupus erythematosus : a case-control study in a Japanese population2012

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, and the Kyushu Sapporo SLE (KYSS) Study Group
    • Journal Title

      J. Rheumatol

      Volume: 39(7) Pages: 1367-1370

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic response of patients with adult Still's disease to biologic agents; multicenter results in Japan2012

    • Author(s)
      Suematsu R, Ohta A, Matsuura E, Takahashi H, Fujii T, Horiuchi T, Minota S, Ishigatsubo Y, Ota T, Takei S, Soejima S, Inoue H, Koarada S, Tada Y, Nagasawa K
    • Journal Title

      Mod. Rheumatol

      Volume: 22(5) Pages: 712-719

    • NAID

      10031027786

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Jamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K
    • Journal Title

      PLoS Genetics

      Volume: 8(1)

    • NAID

      120005906866

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hereditary angioedema in Japan : Genetic analysis of 13 unrelated cases2012

    • Author(s)
      Yam amoto T, Horiuchi T, Miyahara H, Yoshizawa S, Maehara J, Shono E, Takamura K, Machida H, Tsujioka K, Kaneko T, Uemura N, Suzawa K, Inagaki N, Umegaki N, Kasamatsu Y, Hara A, Arinobu Y, Inoue Y, Niiro H, Kashiwagi Y, Harashima SI, Tahira T, Tsukamoto H, Akashi K
    • Journal Title

      Am. J. Med. Sci

      Volume: 343(3) Pages: 210-214

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population2012

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, and the Kyushu Sapporo SLE (KYSS) Study Group
    • Journal Title

      Scand. J. Rheumatol

      Volume: 41(2) Pages: 103-109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research2012

    • Author(s)
      Horiuchi T, Ohi H, Ohsawa I, Fujita T, Matsushita M, Okada N, Seya T, Yamamoto T, Endo Y, Hatanaka M, Wakamiya N, Mizuno M, Nakao M, Okada H, Tsukamoto H, Matsumoto M, Inoue N, Nonaka M, Kinoshita T
    • Journal Title

      Allergol. Int

      Volume: 61(4) Pages: 559-562

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hereditary angioedema in Japan: Genetic analysis of 13 unrelated cases2012

    • Author(s)
      Yamamoto T, Horiuchi T, et al.
    • Journal Title

      Am J Med Sci

      Volume: 343 Pages: 210-214

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sorting nexin 19 regulates the number of sense core vesicles in pancreatic ss-cells2012

    • Author(s)
      Harashima S-I, Horiuchi T, et al.
    • Journal Title

      J Diabetes Invest

      Volume: 3 Pages: 52-61

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population2012

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, et al.
    • Journal Title

      Scand J Rheumatol

      Volume: 41 Pages: 103-109

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking, alcohol consumption and the risk of systemic lupus erythematosus: a case-control study in a Japanese population2012

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, et al.
    • Journal Title

      J Rheumatol

      Volume: 39 Pages: 1367-1370

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells2012

    • Author(s)
      Niiro H, Jabbarzadeh-Tabrizi S, Horiuchi T, et al.
    • Journal Title

      Blood

      Volume: 119 Pages: 2263-2273

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of the MICA polymorphism in systemic lupus erythematosus2011

    • Author(s)
      Yoshida K, Komai K, Shiozawa K, Mashida A, Horiuchi T, Tanaka Y, Nose M, Hashiramoto A, Shiozawa S
    • Journal Title

      Arthritis Rheum

      Volume: 63(10) Pages: 3058-3066

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis : predominant reconstitution of Th1 CD4+ T cells2011

    • Author(s)
      Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K
    • Journal Title

      Rheumatology (Oxford)

      Volume: 50(5) Pages: 944-952

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of and risk factors for low bone mineral density in Japanese female patients with systemic lupus erythematosus2011

    • Author(s)
      Furukawa M, Kiyohara C, Tsukamoto H, Mitoma H, Kimoto Y, Uchino A, Nakagawa M, Oryoji K, Nakashima H, Akashi K, Harada M, Horiuchi T
    • Journal Title

      Rheumatol. Int

      Volume: 31(3) Pages: 365-376

    • NAID

      120004951587

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release2011

    • Author(s)
      Harashima S, Wang Y, Horiuchi T, Seino Y, Inagaki N
    • Journal Title

      J. Neurosci. Res

      Volume: 89(10) Pages: 1519-1530

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk : a case-control study in a Japanese population2011

    • Author(s)
      Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
    • Journal Title

      BMC Cancer

      Volume: 11 Pages: 459-468

    • NAID

      120005133102

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosis2011

    • Author(s)
      Yabuuchi H, Matsuo Y, Tsukamoto H, Sunami S, Kamitani T, Sakai S, Hatakenaka M, Nagafuji K, Horiuchi T, Harada M, Akashi K, Honda H
    • Journal Title

      Eur. J. Radiol

      Volume: 79(2)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of and risk factors for low BMD in SLE2011

    • Author(s)
      Furukawa M, Horiuchi T, et al.
    • Journal Title

      Rheumatol. Int.

      Volume: 31 Pages: 365-376

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immune reconstitution after PBSCT for SSc2011

    • Author(s)
      Tsukamoto H, Nagafuji K, Horiuchi T, et al.
    • Journal Title

      Rheumatology

      Volume: 50 Pages: 944-952

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CT findings of AutoPBSCT for SSc2011

    • Author(s)
      Yabuuchi H, Matsuo Y, Horiuchi T, et al.
    • Journal Title

      Eur. J. Radiol.

      Volume: 79 Pages: 74-79

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] PCP 4 regulates neurite outgrowth2011

    • Author(s)
      Harashima S, Wang Y, Horiuchi T, et al.
    • Journal Title

      J. Neurosci. Res.

      Volume: 89 Pages: 1519-1530

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] MTHF reductase polymorphism2011

    • Author(s)
      Kiyohara C, Horiuchi T, et al.
    • Journal Title

      BMC Cancer

      Volume: 11 Pages: 459-468

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 難治性自己免疫疾患に対する造血幹細胞移植療法-その基礎と臨床-2013

    • Author(s)
      塚本浩、堀内孝彦
    • Organizer
      第41回日本臨床免疫学会総会
    • Place of Presentation
      下関
    • Year and Date
      2013-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 我が国におけるTRAPS(TNF受容体関連周期性症候群)の特徴2013

    • Author(s)
      堀内孝彦
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2013-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 全身性エリテマトーデス―病態解明と治療の最近の進歩―2012

    • Author(s)
      堀内孝彦
    • Organizer
      第27回日本臨床リウマチ学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2012-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 難治性炎症性疾患の画期的治療薬-抗TNF製剤の基礎と臨床-2011

    • Author(s)
      堀内孝彦
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 全身性エリテマトーデスの病態解明と治療-最近の進歩-

    • Author(s)
      堀内孝彦
    • Organizer
      第55回日本リウマチ学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] 我が国におけるTRAPS(TNF受容体関連周期性症候群)の特徴

    • Author(s)
      堀内孝彦
    • Organizer
      第116回小児科学会シンポジウム
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 難治性自己免疫疾患に対する造血幹細胞移植療法 -その基礎と臨床-

    • Author(s)
      塚本浩、堀内孝彦
    • Organizer
      第41回日本臨床免疫学会シンポジウム
    • Place of Presentation
      下関
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TNF阻害薬の作用機序 ―共通点と相違点、そして臨床効果との関連―

    • Author(s)
      堀内孝彦
    • Organizer
      第22回日本脊椎関節炎学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 全身性エリテマトーデス ―病態解明と治療の最近の進歩―

    • Author(s)
      堀内孝彦
    • Organizer
      第27回日本臨床リウマチ学会総会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] TNF阻害薬の登場から10年たって -その現状と未来-

    • Author(s)
      堀内孝彦
    • Organizer
      第32回日本炎症・再生医学会(招待講演)
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 難治性炎症性疾患の画期的治療薬-抗TNF製剤の基礎と臨床-

    • Author(s)
      堀内孝彦
    • Organizer
      第40回日本免疫学会学術集会(招待講演)
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://create2011.jp/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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