| Project/Area Number |
23591465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIMA Kazuhiko 佐賀大学, 医学部, 講師 (60336112)
SUZUKI Shoichi 佐賀大学, 医学部, 助教 (40253695)
SHIRAISHI Hiroshi 佐賀大学, 医学部, 助教 (80452837)
OHTA Shoichiro 佐賀大学, 医学部, 助教 (20346886)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アレルギー / ぜんそく / トランスレーショナルリサーチ / 免疫学 / 生体分子 / 国際情報交換（アメリカ） / 国際情報交換（スエーデン） / 国際情報交換（イギリス） / 国際情報交換（韓国） / 国際情報交流 |
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| Research Abstract |
It is well known that type 2 immunity is important for allergicinflammation. To examine how IL-4 or IL-13, signature type 2 cytokines, contributes to the pathogenesis of allergic inflammation, we in this study analyzed functions of periostin,an extracellular matrix protein induced by IL-4 or IL-13. We found that periostin playsan important role for the chronicity of allergic inflammation in atopic dermatitis. IL-4 or IL-13 induces periostin production in fibroblasts. Periostin induces TSLP production in keratinocytes by binding to integrin molecules on their cell surface. Then TSLP induces Th2 differentiation in naive T cells. Thus, the vicious cycle composed of IL-4/IL-13, periostin, integrin, and TSLP is important for the pathogenesisof atopic dermatitis. The finding that the neutralizing antibodies against av integrin inhibited dermatitis suggests that periostin can be a therapeutic target against atopic dermatitis. We also found that periostin is involved in the pathogenesis of variousinflammatory diseases such as pulmonary fibrosis, scleroderma, gallbladder carcinoma,IgG4-related sclerosing sialadenitis, eosinophilic otitis media, allergic rhinitis and chronic rhinosinusitis, and proliferative diabetic retinopathy. Furthermore, we found that periostin plays an important role in wound repair, which is a physiological function of periostin. The underlying mechanism of the chronicity of allergic inflammationby periostin is the first example showing some host factor is involved in it. It is hopedthat development of inhibitors targeting periostin will lead to development of therapeutic agents against atopic dermatitis having a novel mechanism.
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